Surgery for soft tissue sarcoma in the extremities: A multivariate analysis of the 6–26-year prognosis in 137 patients

Soft-tissue sarcoma of the thigh: Surgical margin influences local recurrence but not survival in 152 patients

“…Many studies (Stotter et al 1990, Berlin et al 1990, Gaynor et al 1992, Coindre et al 1996, including ours have not found tumor size important for local control. Most (Collin et al 1987, Mandard et al 1989, Stotter et al 1990, Gaynor et al 1992, Gustafson 1994, Singer et al 1994, Coindre et al 1996, Li et al 1996, Pisters et al 1996, Vraa et al 1998) have shown tumor size to be a prognostic factor for survival, but our study did not confirm this.…”

“…Histological grade and tumor size are agreed to be of importance for survival. Radical surgery results in a better local control (Alho et al 1989, Mandard et al 1989, Berlin et al 1990, Stotter et al 1990, Gaynor et al 1992, Coindre et al 1996, Pisters et al 1996, but few studies have found an improved survival in patients treated with radical surgery (Stotter et al 1990, Singer et al 1994, Coindre et al 1996, Vraa et al 1998. Most authors have included a heterogeneous group of patients with soft-tissue sarcomas located in both upper and lower extremities and the trunk wall.…”

“…About one third of all sarcomas are located in the thigh. Numerous studies have analyzed prognostic factors concerning local control and survival (Collin et al 1987, Alho et al 1989, Berlin et al 1990, Stotter et al 1990, Gaynor et al 1992, Gustafson 1994, Singer et al 1994, Coindre et al 1996, Pisters et al 1996, Li et al 1996, Guillou et al 1997. Histological grade and tumor size are agreed to be of importance for survival.…”

Surgical margins for soft tissue sarcoma

“…One explana-tion of these different local recurrence rates, after wide and compartmental margins, may be local tumor spread because of open biopsy. Several of the tumors in the Scandinavian series (Rydholm and Rooser 1987, Alho et al 1989, Berlin et al 1990, southern Swedish database) were operated on without open biopsy and in the other cases open biopsy was commonly performed by experts at a treatment center. The variation in rates after marginal excision may be explained by referral bias; patients who suffer a local recurrence are more often referred than patients who do not have a recurrence.…”

Soft Tissue Sarcomas

“…Treatment and prognosis depend more on tumor site, tumor size, and histologic malignancy grade than on exact histological type (14)(15)(16)(17)(18)(19). A four-grade malignancy scale is used in Scandinavia.…”