Surgery improves survival in bladder signet-ring cell carcinoma-a population-based study

Abstract

Objectives: The purpose of this study is to determine the therapeutic value of surgery in individuals with urinary bladder signet ring cell carcinoma (SRCC). Surgery has not been examined as a prognostic factor for urinary bladder cancer (SRCC). Materials and Methods: Using the Surveillance, Epidemiology, and End Results program (SEER), patients with urinary bladder SRCC who presented from 1975 to 2018 were included in a retrospective study. The effect of surgical therapy on cause-specific survival (CSS) and overall survival (OS) was examined using univariate and multivariate Cox regression models. We subdivided 595 patients with SRCC into 2 groups, as follows: 496 who underwent surgery; and 99 who did not undergo surgery. Results: Males had high predominance in all cases in both groups ( p = 0.04). Moderate and poor differentiation (III–IV) were observed in the majority of patients who underwent surgery (77.2 vs 58.6, p ⩽ 0.001) and had no insurance ( p ⩽ 0.001). By using KM, the OS and CSS of the surgery group were found to be significantly better than those of the non-surgery group ( p = 0.001,%) after adjusting for the variables of age, race, sex, primary site, grade, stage, lymph node removal, chemotherapy record, radiotherapy record, insurance, and marital status in the multivariate Cox proportional hazard model (hazard ratio [HR]= 0. 592; 95% confidence interval [CI] = 0.449–0.782; p = 0.0001). In comparison with chemotherapy and radiation, which resulted in poorer survival rates, surgery considerably improved survival outcomes in urinary bladder SRCC. The nomogram prediction model was built with C-index values of 0.70 and 73 for OS and CSS prediction, respectively. AUC in OS values were 0.77, 0.76, and 0.74, whereas AUC in CSS were 0.83, 0.80, and 0.79 for the 1-, 3-, and 5-year survival nomograms, respectively. Conclusion: Surgery was a significant independent predictor of bladder SRCC survival. Patients who underwent surgery had higher CSS and OS than people who did not undergo surgery. Surgery also led to better survival than the combination of the different treatment modalities.

Effect of chemotherapy on prognosis in patients with primary pancreatic signet ring cell carcinoma: A large real-world study based on machine learning

“…The following limitations of this study should be considered. First, there was selection bias in this study, for being a retrospective analysis [ 14 ]. Second, due to the limitations of the SEER database, the concrete chemotherapy regimen and the details of local regional recurrence data were not available, to impact the survival.…”

“…Finally, A total of 588 patients were enrolled in the study. The histologic type was classified using the International Classification of Disease for Oncology, 3rd Edition (ICD-O-3), and the tumor stage categorized using Seer historic stage [ 14 ].…”

Molecular genetic and clinical characteristic analysis of primary signet ring cell carcinoma of urinary bladder identified by a novel OR2L5 mutation

“…Cazier et al, on the other hand, demonstrated that these genes are extremely carcinogenic in ordinary bladder cancer 27 . Finally, by using the last updated edition of the SEER database, the survival comparison between SRCC and UC revealed that ordinary urothelial carcinoma has a greater survival rate, which will explain the difference in gnomic characteristics and driving pathways between the two diseases 37–39 …”

“…27 Finally, by using the last updated edition of the SEER database, the survival comparison between SRCC and UC revealed that ordinary urothelial carcinoma has a greater survival rate, which will explain the difference in gnomic characteristics and driving pathways between the two diseases. [37][38][39] But there are limitations to our analysis. First, due to the rarity of the disease, only a small number of cases were available for analysis.…”

Clinicopathological Characteristics and Prognostic Factors of Primary Bladder Signet Ring Cell Carcinoma

“…Surgery operation and lymph nodes removal are considered protective prognostic factors in prolonged patients' survival. Alradhi et al [ 22 ] reported that surgery served as a significant independent protective factor for PSRCC survival. However, whether surgery should be the most appropriate surgical modality was not further analyzed.…”