Background: To investigate the effect of Sleeve Gastrectomy (SG) in patient with a Body Mass Index (BMI)≥50 kg/m² groups on weight loss and comorbidities as the first and alone option. Methods: The prospectively maintained data obtained from patients with a BMI ≥ 50 who underwent SG between February, 2016 - February, 2020 were evaluated. Results: 138 patient with a BMI≥50 kg/m² underwent surgery. Average BMI: 56.36±7.661, age 37.41±12.33. Forty eight patients underwent cholecystectomy and/or hiatal hernia repair (HHR), as well. The percentage of excess weight loss (%EWL) values of patients in months 3, 6, 12 and 24 were 36.70%, 54.34%, 67.58%, 72.45%, 74.14% and the percentage of total weight loss (TWL%) values were 20.17%, 29.59%, 36.93%, 39.62%, 40.65%, respectively. The mean BMI values in month 0 and in the 3rd, 6th, 12th, 18th, 24th months were 56.36, 45.10, 39.76, 35.48, 33.96 and 33.42 respectively. The values measured in the month 0 and in the 3rd, 6th, 12th, 18th, 24th months were significantly different for EWL%, TWL% and BMI variables (p<0.001), but EWL% (p = 0.527), TWL% (p = 0.396) and BMI (p=0.657) were not found significantly different between the 18th and 24th months. When EWL% was accepted as ≥50, the success rate was found to be 93.55%(n=93) and 92%(n=50) in months 12 and 24, respectively. Conclusion: SG appears to be an effective and safe treatment method as the first option for weight loss and for treatment of concomitant disorders in patient with a BMI ≥ 50 kg/m² groups. Further long-term studies are needed to confirm these results.