Surgical adhesive may cause false positives in integrated positron emission tomography and computed tomography after lung cancer resection

Ruiz-Zafra, Javier; Rodrı́guez-Fernández, Antonio; Sánchez-Palencia, Abel; Cueto, Antonio Serrano

doi:10.1093/ejcts/ezs643

Cited by 20 publications

(5 citation statements)

References 5 publications

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“…Foreign body reaction against these derivates have been reported in the literature by several clinical cases [22]. In [ 18 F]FDG PET/CT studies a similar reaction has been described in other organs as lungs [23]. Also, our patient histological pattern could fit adequately in this context [24].…”

Section: Discussionsupporting

confidence: 77%

[18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression

Rudolphi‐Solero¹,

Triviño-Ibáñez²,

Martínez-Barbero³

et al. 2022

Preprint

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A right frontoparietal neoplastic lesion was found in a young-aged patient with analgesic refractory headache. Surgical resection was performed, and the pathologist analysis turned out a cellular ependymoma with signs of anaplasia. In the follow-up, a MRI showed a suspicious lesion, so a [18F]Fluorocholine PET/CT was performed. An increased uptake was described in the right parietal region on the margin of residual cystic lesion. The patient got a complete resection which was confirmed later by MR. In the pathology analysis, a focally congestive cerebral parenchyma with a central histiocytic reaction to foreign body area was described. Foreign body reaction in brain tissue is a very rare immune response that has not been well studied. Haemostatic material has been reported as a possible trigger of this response in other organs and could be detected by [18F]FDG PET/CT. Following the experience of the current case report, [18F]Fluorocholine PET/CT could also show a false positive related to foreign body reaction.

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Section: Discussionsupporting

confidence: 77%

[18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression

Rudolphi‐Solero¹,

Triviño-Ibáñez²,

Martínez-Barbero³

et al. 2022

Preprint

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“…Absorbable material has also been incriminated in cases of granuloma mimicking recurrence on PET-CT such as polyglycolic acid sheet and suture on pulmonary segmentectomy, surgical adhesive after lung cancer resection [28] or haemostatic compresses of fibrillar cellulose (Surgicel ® ) in intra-cerebral [29], cardiac [30] and gynaecologic surgeries [31].…”

Section: Discussionmentioning

confidence: 99%

False positive PET-CT imaging after application of fibrin-based sponge at the site of previous hepatic resection for colo-rectal metastasis: A short series

Grandjean,

Bertrand,

Krug

et al. 2023

Open J Clin Med Case Rep

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Surgical resection is the treatment of choice with curative intent for colorectal liver metastasis. Preoperative accurate radiological staging is key for optimal treatment. Fluorine-18 fluorodeoxyglucose PET-CT (PETCT) is effective for this purpose. We present 4 cases of patients with history of hepatectomy for colorectal liver metastasis. In all patients, during the procedure, we used fibrin-based sponge to achieve optimal haemostasis of the parenchymal transection surface. During the oncologic follow-up, a suspicion of disease recurrence justified a staging PET-CT that revealed pathologic metabolic activity on sites of previous liver resection, highly suspicious of tumour recurrence. The delay between hepatectomy and PET-CT for recurrence ranged from 5 to 12 months. In all cases, a new surgical exploration was performed after neoadjuvant chemotherapy, and PET-CT positive sites of previous liver resection were removed. Definitive histological diagnosis showed inflammatory granuloma or fibrous tissue.

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“…Ruiz-Zafra, et al described two cases of surgical adhesive, which are frequently used after pulmonary resection to prevent or reduce pulmonary air leakages, as the cause of the false-positive PET/CT. Subsequent surgical exploration showed that the lesions were foreign body reactions to the bioadhesive [ 6 ]. Yüksel, et al and Lim, et al described a total of five cases of PET/CT-positive inflammatory nodules that developed secondary to suture or stapler material granulomas [ 7 - 8 ].…”

Section: Discussionmentioning

confidence: 99%

"All That Glitters Is Not Gold" - A Case of an Occult Foreign Body in the Lung with Elevated 2-[18F]-Fluoro-2-deoxy-D-glucose (FDG) Uptake Mimicking Bronchogenic Carcinoma

Kanchustambham

Schenone

et al. 2017

Cureus

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Combined positron emission tomography/computed tomography (PET/CT) using the glucose analogue 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) has become the standard of care in oncological patients. However, due to the non-specific nature of FDG uptake, there are many physiological variants and benign pathological entities that also demonstrate augmented glucose metabolism, such as inflammatory and infective processes. Undiagnosed and retained foreign bodies (occult foreign bodies) in the lung can induce inflammatory reaction consisting of polymorphonuclear neutrophils, macrophages, and granulation tissue resulting in intense FDG uptake because of high metabolic activity and cell turnover. Here, we present a case of an occult foreign body imitating a tumor on PET/CT.

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Surgical adhesive may cause false positives in integrated positron emission tomography and computed tomography after lung cancer resection

Cited by 20 publications

References 5 publications

[18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression

[18F]Fluorocholine PET/CT False Positive: Foreign Body Reaction Mimicking Low-Grade Glioma Progression

False positive PET-CT imaging after application of fibrin-based sponge at the site of previous hepatic resection for colo-rectal metastasis: A short series

"All That Glitters Is Not Gold" - A Case of an Occult Foreign Body in the Lung with Elevated 2-[18F]-Fluoro-2-deoxy-D-glucose (FDG) Uptake Mimicking Bronchogenic Carcinoma

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