Surgical excision with the negative margins offers best cure rates for ameloblastoma: A case series and review of literature

Singhavi, Hitesh; Pai, Ameya; Mair, Manish; Nair, Sudhir; Nair, Deepa; Chaturvedi, Pankaj

doi:10.4103/jhnps.jhnps_1_20

Cited by 3 publications

(6 citation statements)

References 23 publications

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“…There are few studies in the literature with adequate follow-up of case series using the same protocol of treatment. [4][5][6][7] From the demographic point of view, our unicystic ameloblastoma cases were predominantly observed in patients between the second and third decades of life, which is similar to other studies, 8,9 and in female individuals, contrary to what is observed in the literature. 2,10,11 This difference regarding gender can be explained by the reduced sample size.…”

Section: Discussionsupporting

confidence: 87%

“…8 In our opinion, although these factors described above, the recurrence should be explained by the most invasive behavior of the mural UAM subtype, which is validated by other studies. 3,4,18 Curiously, this case corresponded to our older patient (61 years) which may suggest a link between age and recurrence rates. Further studies are necessary to investigate this association.…”

Section: Discussionsupporting

confidence: 53%

“…The present study retrospectively evaluated the influence of clinical, imaging, histological, and surgical factors on the recurrence rates of 12 patients with UAM treated by one of the authors (Wagner Henriques de Castro) through the same therapeutic protocol over 20 years. There are few studies in the literature with adequate follow‐up of case series using the same protocol of treatment 4–7 …”

Section: Discussionmentioning

confidence: 99%

“…Since the analysis of the whole specimen is only possible after resection or enucleation, a rational approach for the management of unicystic ameloblastoma based on incisional biopsy is a challenging topic. 4 Treatment modalities available for UAM range from conservative (marsupialization, enucleation, and curettage with or without adjuvant therapies) to radical (marginal or segmental resection) ones. There is no defined protocol management of UAM, and the choice between these options is based on factors like lesion size, location, patients' age, surgeons' practice, and patients' decision.…”

Section: Introductionmentioning

confidence: 99%

“…The final diagnosis is defined after histopathological evaluation of the whole excised specimen because the fragment removed through incisional biopsy could not be representative. Since the analysis of the whole specimen is only possible after resection or enucleation, a rational approach for the management of unicystic ameloblastoma based on incisional biopsy is a challenging topic 4 …”

Section: Introductionmentioning

confidence: 99%

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A conservative approach for unicystic ameloblastoma: Retrospective clinic‐pathologic analysis of 12 cases

Leite-Lima

Martins‐Chaves

Fonseca

et al. 2023

J Oral Pathology Medicine

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BackgroundUnicystic ameloblastoma is an encapsulated odontogenic neoplasm with a single cyst cavity. The conservative or aggressive surgical approaches used to treat the tumor directly affect recurrence rates. However, there is a lack of a standard protocol that can guide its management.Study DesignWe retrospectively reviewed the clinicopathological findings and therapeutical procedures of 12 unicystic ameloblastoma cases treated by the same surgeon during the past 20 years.MethodsAll cases of unicystic ameloblastoma diagnosed by biopsy and treated by the same surgeon between 2002 and 2022 were reviewed. Eligibility criteria were patients with completely filled‐out charts containing the follow‐up period and confirmation of the diagnoses based on the microscopic findings of the whole excised specimens. Data collected were categorized into clinical, radiographic, histological, surgical, and recurrence aspects.ResultsThere was a female predilection (2:1), and ages ranged between 18 and 61 years (mean: 27.25, ±12.45). Almost all (92%) affected the posterior mandible. Radiographically, the mean length of the lesions was 46.14 mm ± 14.28 mm which 92% were unilocular and 8.3% multilocular. Root resorption (n = 7, 58%), tooth displacement (n = 9, 75%), and cortical perforation (n = 5, 42%) were also observed. The mural histological subtype corresponded to 9 (75%) of the cases. The same conservative protocol was performed in all cases. The follow‐up period ranged between 12 and 240 months (~62 ± 65) and recurrence occurred in only one patient (8%).ConclusionOur findings suggest a conservative approach should be the first option for unicystic ameloblastoma treatment, even for those with mural proliferation.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A conservative approach for unicystic ameloblastoma: Retrospective clinic‐pathologic analysis of 12 cases

Leite-Lima

Martins‐Chaves

Fonseca

et al. 2023

J Oral Pathology Medicine

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Surgical management of conventional ameloblastoma: a retrospective cohort study over the past 21 years

Leite-Lima,

Martins-Chaves,

de Castro

et al. 2024

Oral Maxillofac Surg

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Maxillary Acanthomatous Ameloblastoma With Orbital Involment - A Rare Clinical Variant

Murali

Genedi

Saravanam

2021

ijsr

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Ameloblastoma is a group of rare benign odontogenic tumour, accounting for around 1% of all the cysts and tumours in the jaw. Predominantly this tumour occurs in the mandible and rarely crosses the midline. The typical clinical presentation is that of facial dysmorphism and functional dysfunction due to the expansile and compressive nature of the tumour. Of the six histological subtypes described, Acanthomatous variant is relatively very rare. A Large ameloblastoma with acanthomatous variant of maxilla is also unusual. This case discusses the diagnostic and therapeutic challenges in the management of a large maxillary acanthomatous ameloblastoma that had extended into the orbit, ethmoids and sphenoid sinus.

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Surgical excision with the negative margins offers best cure rates for ameloblastoma: A case series and review of literature

Cited by 3 publications

References 23 publications

A conservative approach for unicystic ameloblastoma: Retrospective clinic‐pathologic analysis of 12 cases

A conservative approach for unicystic ameloblastoma: Retrospective clinic‐pathologic analysis of 12 cases

Surgical management of conventional ameloblastoma: a retrospective cohort study over the past 21 years

Maxillary Acanthomatous Ameloblastoma With Orbital Involment - A Rare Clinical Variant

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