Surgical options in early cervical cancer

Rob, Lukáš; Robová, Helena; Chmel, Roman; Komar, M; Halaška, Michael; Škapa, Petr

doi:10.3109/02656736.2012.675116

Cited by 15 publications

(6 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study showed an 8.4% (24/284) rate of LNM in patients with FIGO stage IB1 CC, a finding that is in accordance with those of other studies ( 12 – 14 ). The 5-year OS rate in patients with LNM was significant lower than patients without LNM.…”

Section: Discussionsupporting

confidence: 93%

“…However, some patients experience sequelae from this procedure (such as vascular or nerve injury, pelvic lymphocyst, and lower-limb lymphedema), which may increase the length of hospital stay and affect quality of life ( 7 – 9 ). In addition, the rate of LNM in FIGO stage IB1 patients was 7–17.4% ( 12 – 14 ). Lymphadenectomy may not have a survival benefit, but it may increase the incidence of postoperative complications in LNM-negative patients.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, some patients experience sequelae after lymphadenectomy, such as vascular or nerve injury, pelvic lymphocysts, and lower-limb lymphedema, which can be life-threatening, increase length of hospital stay, and affect quality of life ( 7 – 9 ). The incidence of LNM in early-stage CC is reportedly 15–20% ( 10 , 11 ) and even lower in FIGO stage IB1 patients at 7–17.4% ( 12 – 14 ). Therefore, exploring the risk factors of LNM in FIGO stage IB1 and classifying patients into different groups to avoid the risk caused by lymph node dissection for low-risk patients is of great clinical significance.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer

Xie

Cai

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

ObjectivesTo assess the risk factors of lymph node metastasis (LNM) in patients with FIGO stage (2009) IB1 cervical cancer (CC).MethodsPatients with FIGO stage IB1 CC who underwent radical resection between 2012 and 2018 were recruited. The risk factors for LNM were analysed. A recursive partitioning analysis (RPA) was used to divide the patients into risk groups and assess their risk of LNM.ResultsThe 5-year overall survival rate was 91.72%, while 80.0% and 93.5% for patients with or without LNM (P<0.05). Multivariable logistic regression analysis showed that lymphovascular invasion (LVI), depth of invasion (DI), tumour size (TS), squamous cell carcinoma (SCC) antigen level were independent risk factors (all P<0.05). Patients were divided into low-risk (no LVI, DI <1/2, TS <2 cm), intermediate-risk (no LVI, DI <1/2, TS ≥2 cm; no LVI, DI ≥1/2, normal SCC level; LVI, DI <1/2, TS <2 cm), and high-risk (no LVI, DI ≥1/2, SCC level ≥1.5 ng/ml; LVI, TS <2 cm, DI ≥1/2; LVI, TS ≥2 cm) groups by RPA according to these four factors. The incidence of LNM among the three groups was 0.00%, 4.40%, and 24.10%, respectively (all P<0.001). The 5-year overall survival rates differed among the groups (98.2%, 92.7%, 83.0%, respectively, P=0.001).ConclusionsLNM affects the prognosis of patients with FIGO stage IB1 CC. Lymphadenectomy may be avoided for patients in the low-risk group and recommended for those in the high-risk group. Whether dissection is performed in the intermediate-risk group depends on the lymph node biopsy results.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer

Xie

Cai

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Best results are obtained by electrosurgical procedures using a needle (NETZ) or loop (LLETZ) with radiofrequency energy. In IA1 with LVSI tumours, a lymphadenectomy must be combined with cone biopsy [ 19 ]. For IA2 tumours, usually VRT with pelvic lymphadenectomy is chosen though some centres also use cone biopsy or ST combined with lymphadenectomy [ 20 ].…”

Section: Preoperative Workoutmentioning

confidence: 99%

The role of trachelectomy in cervical cancer

Halaška

Robová

Pluta

et al. 2015

ecancer

View full text Add to dashboard Cite

Cervical cancer is one of the most common cancers in women worldwide. Because it often affects women of childbearing age (19–45 years), fertility-sparing surgery is an important issue. The article reviews current viable fertility-sparing options with a special focus on trachelectomy, including vaginal radical trachelectomy, abdominal radical trachelectomy and simple trachelectomy. Neoadjuvant chemotherapy is also discussed. Finally, the decision to proceed with fertility-sparing treatment should be a patient-driven process.

show abstract

“…In early cervical cancer, the status of regional lymph nodes is a critical factor in determining prognosis. Systematic pelvic lymph node dissection is routinely performed as part of standard surgical therapy, except stage IA1 [ 11 ]. Systematic pelvic lymphadenectomy is associated with short-and long-term morbidities, such as increased blood loss, neurovascular injury, lymphocyst formation and infection, and lowerlimb lymphedema [ 3 ].…”

Section: Introductionmentioning

confidence: 99%