Surgical techniques for aortic valve xenotransplantation

Kwon, Jennie H.; Hill, Morgan A.; Gerry, Brielle; Kubalak, Steven W.; Mohiuddin, Muhammad M.; Kavarana, Minoo N.; Rajab, Taufiek Konrad

doi:10.1186/s13019-021-01743-0

Cited by 6 publications

(6 citation statements)

References 44 publications

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“…Last but not least, prodigious progress in the field of xenotransplantation 53 raises the promise of an unlimited supply of donor grafts. Our preliminary experiments show that partial heart xenotranplantation 54‐56 is feasible.…”

Section: Donor Pool For Partial Heart Transplantationmentioning

confidence: 89%

Partial heart transplantation: Growing heart valve implants for children

Rajab

2023

Artificial Organs

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Heart valves serve a vital hemodynamic function to ensure unidirectional blood flow. Additionally, native heart valves serve biological functions such as growth and self‐repair. Heart valve implants mimic the hemodynamic function of native heart valves, but are unable to fulfill their biological functions. We developed partial heart transplantation to deliver heart valve implants that fulfill all functions of native heart valves. This is particularly advantageous for children, who require growing heart valve implants. This invited review outlines the past, present and future of partial heart transplantation.

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Section: Donor Pool For Partial Heart Transplantationmentioning

confidence: 89%

Partial heart transplantation: Growing heart valve implants for children

Rajab

2023

Artificial Organs

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“…15 If xenotransplantation of piglet organs, tissues, and cells could be implemented, organs would be available almost immediately and may be feasible in patients that currently may not qualify for organ transplantation. 32 Genetically modified porcine to human cardiac xenotransplantation has recently been attempted, but the xenograft failed from diastolic ventricular failure. 33 The longest reported survival time of pig heart transplant into nonhuman primates is around 500 days.…”

Section: Orthotopic Partial He Art Tr An S Pl Antati Onmentioning

confidence: 99%

“…Xenotransplantation stands to provide a solution to this issue, potentially producing donor grafts in unlimited supply 15 . If xenotransplantation of piglet organs, tissues, and cells could be implemented, organs would be available almost immediately and may be feasible in patients that currently may not qualify for organ transplantation 32 . Genetically modified porcine to human cardiac xenotransplantation has recently been attempted, but the xenograft failed from diastolic ventricular failure 33 .…”

Section: Partial Heart Xenotransplantationmentioning

confidence: 99%

Animal models for partial heart transplantation

Yerger,

Hill,

Fitzgerald

et al. 2024

Pediatric Transplantation

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BackgroundPartial heart transplantation delivers growing heart valve implants by transplanting the part of the heart containing the necessary heart valve only. In contrast to heart transplantation, partial heart transplantation spares the native ventricles. This has important implications for partial heart transplant biology, including the allowable ischemia time, optimal graft preservation, primary graft dysfunction, immune rejection, and optimal immunosuppression.AimsExploration of partial heart transplant biology will depend on suitable animal models. Here we review our experience with partial heart transplantation in rodents, piglets, and non‐human primates.Materials & MethodsThis review is based on our experience with partial heart transplantation using over 100 rodents, over 50 piglets and one baboon.ResultsSuitable animal models for partial heart transplantation include rodent heterotopic partial heart transplantation, piglet orthotopic partial heart transplantation, and non‐human primate partial heart xenotransplantation.DiscussionRodent models are relatively cheap and offer extensive availability of research tools. However, rodent open‐heart surgery is technically not feasible. This limits rodents to heterotopic partial heart transplant models. Piglets are comparable in size to children. This allows for open‐heart surgery using clinical grade equipment for orthoptic partial heart transplantation. Piglets also grow rapidly, which is useful for studying partial heart transplant growth. Finally, nonhuman primates are immunologically most closely related to humans. Therefore, nonhuman primates are most suitable for studying partial heart transplant immunobiology and xenotransplantation.ConclusionsAnimal research is a privilege that is contingent on utilitarian ethics and the 3R principles of replacement, reduction and refinement. This privilege allows the research community to seek fundamental knowledge about partial heart transplantation, and to apply this knowledge to enhance the health of children who require partial heart transplants.

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“…In the future, this may be addressed using partial heart xenotransplantation. 38,39 Second, the cost for partial heart transplant is likely similar to the cost of OHTs. Third, due to the technical nature of this procedure, it is best performed by experienced surgeons in a medium- to high-volume cardiac transplant center to ensure the best outcomes for patients.…”

Section: Advantages and Disadvantagesmentioning

confidence: 99%

Partial Heart Transplantation in Adult Cardiac Surgery

Sherard

Bisbee

Konsek

et al. 2023

Innovations�(Phila)

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Many young adults require heart valve replacements. Current options for valve replacement in adults include mechanical valves, bioprosthetic valves, or the Ross procedure. Of these, mechanical and bioprosthetic valves are the most common options, although mechanical valve usage predominates in younger adults due to durability, while bioprosthetic valve usage predominates in older adults. Partial heart transplantation is a new method of valvular replacement that can deliver durable and self-repairing valves and allow adult patients freedom from anticoagulation therapy. This procedure involves transplantation of donor heart valves only, permitting expanded utilization of donor hearts as compared with orthotopic heart transplantation. In this review, we discuss the potential benefits of this procedure in adults who elect against the anticoagulation regimen required of mechanical valve replacements, although it has not yet been clinically established. Partial heart transplantation is a promising new therapy for the treatment of pediatric valvular dysfunction. This is a novel technique in the adult population with potential utility for valve replacement in young patients for whom anticoagulation therapy is problematic, such as women who wish to become pregnant, patients with bleeding disorders, and patients with active lifestyles.

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Surgical techniques for aortic valve xenotransplantation

Cited by 6 publications

References 44 publications

Partial heart transplantation: Growing heart valve implants for children

Partial heart transplantation: Growing heart valve implants for children

Animal models for partial heart transplantation

Partial Heart Transplantation in Adult Cardiac Surgery

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