Surgical treatment strategy for advanced hepatoblastoma: Resection versus transplantation

Uchida, Hajime; Sakamoto, Seisuke; Sasaki, Kengo; Takeda, Masatoshi; Hirata, Yoshihiro; Fukuda, Akira; Hishiki, Tomoro; Irie, Rie; Nakazawa, Atsuko; Miyazaki, Osamu; Nosaka, Shunsuke; Kasahara, Mureo

doi:10.1002/pbc.27383

Cited by 36 publications

(40 citation statements)

References 31 publications

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“…Nevertheless, this correlation was maintained even after adjusting for other variables classically associated with worse outcomes after LT, such as older age at LT and rescue transplantation. 11,12,16 No significant relationship was observed for any of the other variables in our study (transplantation as primary or rescue therapy, macrovascular invasion, metastatic disease at diagnosis, tumor histology, tumor rupture, PRETEXT, etc).…”

Section: Discussioncontrasting

confidence: 53%

“…The correlation between AFP levels at the moment of LT and the possibility of a incurable relapse should be interpreted with caution in the context of the limited number of patients. Nevertheless, this correlation was maintained even after adjusting for other variables classically associated with worse outcomes after LT, such as older age at LT and rescue transplantation …”

Section: Discussionmentioning

confidence: 87%

“…Although the data of original studies were clear, the worst results of the rescue transplantation group were neither adjusted for the interval between the first surgery and transplantation, nor for the chemosensitivity that the tumor exhibited at the time of LT. Therefore, we suggest that the recommendations derived from these series be carefully reviewed, also considering new evidence that shows acceptable results even in extreme resections with positive microscopic margins, provided they are carried out at centers with sufficient expertise and the possibility of “back‐up” LT …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Changes in AFP levels and tumor size during chemotherapy are the most commonly accepted markers of biological response to chemotherapy in HB . Additionally, high AFP levels on completion of neoadjuvant chemotherapy have been associated with worse outcomes . Although there is not a unique definition of chemosensitivity vs chemoresistance in HB, it has been observed that patients who are considered chemoresistant have a worse prognosis after any surgical modality .…”

Section: Discussionmentioning

confidence: 99%

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Prognostic factors for event‐free survival in liver transplantation for hepatoblastoma: A single‐center experience

Lauferman

Halac

Aredes

et al. 2019

Pediatric Transplantation

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Hepatoblastoma (HB) is the most common malignant liver tumor in children. Twenty percent of the cases may remain unresectable after neoadjuvant chemotherapy and, for these patients, liver transplant (LT) is an accepted therapeutic option. To analyze the risk factors to event‐free survival (EFS) that influence the clinical outcome of patients with HB receiving LT, we retrospectively analyzed 21 patients with HB who underwent LT between January 1, 2005, and May 1, 2018. Overall survival (OS) was 90%. The univariate analysis shows that the AFP level at the time of LT was associated with a higher risk of EFS. With a ROC curve analysis, we established a cutoff point value of AFP levels at 16 000 ng/dL, with a sensitivity of 71.43% and a specificity of 85.71%. Multivariate analysis showed that patients with higher values of pretransplant AFP (>16 000 ng/dL) had a significantly higher risk of EFS than those transplanted with lower levels (HR: 10.180; 95% CI: 1.54‐66.97; P = .02). Efforts should be made to improve the selection of candidates for LT for unresectable HB, aiming at a better definition of chemoresistance as a risk factor of poor outcomes.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic factors for event‐free survival in liver transplantation for hepatoblastoma: A single‐center experience

Lauferman

Halac

Aredes

et al. 2019

Pediatric Transplantation

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Recent advances in surgical strategies and liver transplantation for hepatoblastoma

et al. 2022

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Hepatoblastoma (HB) is the most common malignant liver tumor in children.Although the development of treatment strategies with advances in chemotherapy has greatly improved the prognosis of HB, surgical resection and liver transplantation still play a vital role in the treatment of HB. In recent years, technological innovations have led to the development of new surgical approaches for HB. In this review, we describe the latest research on the surgical management of HB, including new imaging technologies, minimally invasive approaches, and the application of associating liver partition portal vein ligation for staged hepatectomy. We also discuss the current role of liver transplantation, use of antesitum or ex-situ liver resection with auto-transplantation, and management of metastatic HB.

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O‐GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β‐catenin signalling

Cui

Zhu

et al. 2023

Clinical & Translational Med

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Background Accumulating studies have shown that La‐related protein 1 (LARP1) is involved in the occurrence and development of various tumours. However, the expression pattern and biological role of LARP1 in hepatoblastoma (HB) remain unclear so far. Methods LARP1 expression level in HB and adjacent normal liver tissues was analysed by qRT‐PCR, Western blotting and immunohistochemistry assays. The prognostic significance of LARP1 was evaluated by Kaplan–Meier method and multivariate Cox regression analysis. In vitro and in vivo functional assays were implemented to clarify the biological effects of LARP1 on HB cells. Mechanistically, the regulatory roles of O‐GlcNAcylation and circCLNS1A in LARP1 expression were investigated by co‐immunoprecipitation (co‐IP), immunofluorescence, RNA immunoprecipitation (RIP), RNA pull‐down and protein stability assays. Moreover, RNA‐sequencing, co‐IP, RIP, mRNA stability and poly(A)‐tail length assays were performed to investigate the association between LARP1 and DKK4. The expression and diagnostic significance of plasma DKK4 protein in multi‐centre cohorts were evaluated by ELISA and ROC curves. Results LARP1 mRNA and protein levels were remarkably elevated in HB tissues and associated with worse prognosis of HB patients. LARP1 knockdown abolished cell proliferation, triggered cell apoptosis in vitro as well as prohibited tumour growth in vivo, whereas LARP1 overexpression incited HB progression. Mechanistically, O‐GlcNAcylation of LARP1 Ser672 by O‐GlcNAc transferase strengthened its binding to circCLNS1A and then protected LARP1 from TRIM‐25‐mediated ubiquitination and proteolysis. LARP1 upregulation subsequently led to DKK4 mRNA stabilisation by competitively interacting with PABPC1 to prevent DKK4 mRNA from B‐cell translocation gene 2‐dependent deadenylation and degradation, thus facilitating β‐catenin protein expression and nuclear import. Conclusion This study indicates that upregulated protein level of O‐GlcNAcylated LARP1 mediated by circCLNS1A promotes the tumorigenesis and progression of HB through LARP1/DKK4/β‐catenin axis. Hence, LARP1 and DKK4 are promising therapeutical target and diagnostic/prognostic plasma biomarker for HB.

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Surgical treatment strategy for advanced hepatoblastoma: Resection versus transplantation

Abstract: Patients with advanced HB with a poor response to chemotherapy should definitively be prioritized for primary LT, given the possibility of vascular invasion and microscopic residual tumor.

Cited by 36 publications

References 31 publications

Prognostic factors for event‐free survival in liver transplantation for hepatoblastoma: A single‐center experience

Prognostic factors for event‐free survival in liver transplantation for hepatoblastoma: A single‐center experience

Recent advances in surgical strategies and liver transplantation for hepatoblastoma

O‐GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β‐catenin signalling

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