Surveillance colonoscopy practice in Lynch syndrome in the Netherlands: A nationwide survey

Abstract

Lynch syndrome, or hereditary nonpolyposis colorectal cancer (HNPCC), is the most common genetic disorder predisposing to colorectal cancer. As regular colonoscopic surveillance has been shown to reduce the incidence of colorectal cancer, this strategy is recommended worldwide. Recently, several advances in colonoscopic techniques have improved detection rates of neoplasia in Lynch syndrome. In this nationwide survey, we evaluated current surveillance colonoscopy practices for Lynch syndrome in the Netherlands and the extent to which advanced techniques have been adopted in routine clinical practice.

A prospective study of bowel preparation for colonoscopy with polyethylene glycol-electrolyte solution versus sodium phosphate in Lynch syndrome: a randomized trial

“…Up to 5% of all colorectal cancer cases are attributed to the Lynch syndrome [ 1 ].Lynch syndrome is caused by germ line mutations in one of the mismatch repair (MMR) genes MLH1, MSH2, MSH6 or PMS2 [ 2 ]. Lynch syndrome gene carriers are recommended to undergo regular endoscopic surveillance of their colon.…”