2005
DOI: 10.1007/s11934-005-0062-x
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Surveillance following radical or partial nephrectomy for renal cell carcinoma

Abstract: Renal cell carcinoma (RCC) is the most lethal of the common urologic malignancies, with approximately 40% of patients eventually dying of cancer progression. Approximately one third of patients present with metastatic disease and up to 50% treated for localized disease have a recurrence. Although the prognosis generally is poor in these patients, some may respond to immunotherapy and a subset of patients who develop solitary metastases can achieve long-term survival. Therefore, the timely identification of rec… Show more

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Cited by 103 publications
(47 citation statements)
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“…Unfortunately, up to 40% of all patients will show a recurrent disease after surgery [20]. Although recurrences had been reported as late as 30 years following nephrectomy, rates of 43% in the first year, 70% within the second year, 80% within 3 years, and 93% within 5 years had been reported [21]. Therefore, we emphasized the prediction of early recurrence (within 36 months) in our study.…”
Section: Discussionmentioning
confidence: 97%
“…Unfortunately, up to 40% of all patients will show a recurrent disease after surgery [20]. Although recurrences had been reported as late as 30 years following nephrectomy, rates of 43% in the first year, 70% within the second year, 80% within 3 years, and 93% within 5 years had been reported [21]. Therefore, we emphasized the prediction of early recurrence (within 36 months) in our study.…”
Section: Discussionmentioning
confidence: 97%
“…Clear cell RCC (ccRCC) represents >75% of all RCC cases and is the most aggressive of all known RCC subtypes, presenting a complex biological behavior which differs significantly between individuals (2). The post-operative recurrence rate of ccRCC reaches up to 20-40% (3,4). Once metastatic disease develops, the 5-year survival rate for patients with ccRCC decreases from 60% to <5% (5).…”
Section: Introductionmentioning
confidence: 99%
“…[7] Metastases to brain, bone, and liver often present as widely disseminated disease. Current guidelines for metastatic renalcell carcinoma (mRCC) do not recommend routine brain imaging as part of the surveillance protocol unless central nervous system (CNS) symptoms or abnormal laboratory values suggest brain involvement.…”
Section: Discussionmentioning
confidence: 99%