Surveillance of the Activity of Aminoglycosides and Fluoroquinolones Against Ophthalmic Pathogens from Europe in 2010–2011

Sanfilippo, Christine M; Morrissey, Ian; Janes, Regina; Morris, Timothy W.

doi:10.3109/02713683.2015.1045084

Cited by 25 publications

(32 citation statements)

References 18 publications

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“…Highest rates were documented in isolates collected from Germany ( n = 45), with a 31.1% for both drugs. [33] Methicillin resistance was only 9.1% for this group with the highest rates reported for Germany at 20.0%. These rates were significantly lower than those reported in the current study and/or those highlighted in the ARMOR study.…”

Section: Discussionmentioning

confidence: 90%

“…documented differences in nonsusceptibility for gentamicin and tobramycin among S. aureus , CoNS, and P. aeruginosa in a recent surveillance study from Europe. [33] Nonsusceptibility rates for gentamicin among the staphylococci ranged from 2.0% to 28.4%, with highest rates for coagulase-negative isolates. In contrast, the rates for tobramycin against the same isolates ranged from 9.5% to 39.9%, again with rates highest among the coagulase-negative strains.…”

Section: Discussionmentioning

confidence: 99%

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Update on the epidemiology and antibiotic resistance of ocular infections

Miller

2017

Middle East Afr J Ophthalmol

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Update on the epidemiology and antibiotic resistance of ocular infections

Miller

2017

Middle East Afr J Ophthalmol

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“…Staphylococcus aureus is the predominant pathogen isolated from ocular infections (7,8), and BALB/c mice are considered to be more susceptible to Staphylococcus aureus keratitis than C57BL/6 mice (28,29). Therefore, in our study, we selected a BALB/c 0.25 0 a n ϭ 6.…”

Section: Effect Of Diacerein Eye Drop On Treatment Of Staphylococcus mentioning

confidence: 99%

“…The most frequent pathogen in bacterial keratitis associated with non-contact-lensrelated disease is the Gram-positive bacterium (8). We collected and isolated all bacteria from patients with bacterial keratitis between March 2017 and February 2018 at the Henan Eye Hospital in China and obtained 76 clinical isolates of Gram-positive cocci, including 6 common and 9 uncommon species.…”

mentioning

confidence: 99%

In Vitro Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and In Vivo Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice

Zhang

Liu

Yue

et al. 2019

Antimicrob Agents Chemother

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Bacterial keratitis is an aggressive infectious corneal disease. With the continuing rise in antibiotic resistance and a decline in the discovery of new antibiotics, new antimicrobial drugs are now required. In the present study, we determined the antibacterial activity of diacerein, an anti-inflammatory drug, against 76 Gram-positive cocci isolated from bacterial keratitis patients in vitro and anti-Staphylococcus aureus activity in a mouse bacterial keratitis model in vivo. The MICs of diacerein were tested using the broth microdilution method in vitro. A BALB/c Staphylococcus aureus keratitis animal model was selected and the corneal clinical observation, viable bacteria, and hematoxylin-eosin and Gram staining of infected corneas were measured to evaluate the antibacterial efficacy of diacerein eye drops in vivo. An in vivo eye irritation study was carried out by a modified Draize test in rabbits. Our in vitro results showed that diacerein possesses satisfactory antibacterial activity against the majority of Gram-positive cocci (60/76), including all 57 tested Staphylococcus spp. and 3 Enterococcus spp. The in vivo experiment showed that diacerein eye drops reduced bacterial load and improved ocular clinical scores after topical administration of diacerein drops on infected corneas. The ocular irritation test revealed that diacerein eye drop had excellent ocular tolerance. These results indicated that diacerein possesses in vivo anti-Staphylococcus aureus activity. We suggest that diacerein is a possible topically administered drug for Staphylococcus aureus-infected patients, especially those with ocular surface inflammatory disorders.

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“…Širok razpon različ-ne odpornosti po vsej Evropi potrjuje v tej raziskavi pomembnost upoštevanja trenutnih lokalnih vzorcev odpornosti, predvsem kadar se empirično odločamo, katero antibakterijsko zdravilo bomo izbrali za zdravljenje očesnih okužb. 24 ARMOR (angl. The Antibiotic Resistance Monitoring in Ocular Microorganisms) je edini stalni nacionalni program, specifičen za očesne patogene, ki v različnih centrih po celotnih Združenih državah Amerike, nadzira odpornost na antibiotike.…”

Section: Uvodunclassified

Zdravljenje Okužb Roženice S Prečnim Povezovanjem Kolagenih Vlaken

Silih

2016

SlovMedJour

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Zdravljenje okužb roženice s prečnim povezovanjem kolagenih vlakencorneal collagen cross-linking for infectious keratitis mirna Štabuc Šilih IzvlečekPrečno povezovanje kolagenih vlaken roženice z ultravijolično svetlobo poveča stabilnost roženice z uporabo fotosenzitivne snovi -riboflavina (vitamina B2) in ultravijoličnih žarkov A. Osnovna indikacija je napredujoči keratokonus, poseg pa se v svetu vse pogosteje uporablja. Ker gre pri tem postopku za fiziološke spremembe vsega vezivnega tkiva, so bile predlagane še dodatne indikacije. Te so ektazija po operaciji, bulozna keratopatija in predvsem, najbolj zanimiva, infekcijski keratitis.Okužbe roženice lahko brez ustreznega zdravljenja povzročijo slepoto. Vendar je tudi takojšnje in ustrezno antimikrobno zdravljenje odvisno od senzitivnosti in rezistence mikroorganizmov.Prispevek opisuje sedanje možnosti zdravljenja okužb roženice s prečnim povezovanjem kolagenih vlaken.Ta način zdravljenja bo morda postal pomemben, vendar pa ostajajo odprta še mnoga neodgovorjena vprašanja. Odgovore nanje naj bi dali rezultati večjih, prospektivnih primerjalnih raziskav. AbstractCorneal collagen cross-linking increases the stability of the cornea through the use of the photosensitive material-riboflavin (vitamin B2) and ultraviolet A radiation. Progressive keratoconus is the most common indication and the frequency of these procedures is increasing worldwide. As cross-links in the cornea are a physiological principle of all connective tissues, additional indications were proposed. These include post-refractive surgery ectasia, bullous keratopathy, and, infectious keratitis.Without proper antimicrobial therapy, infectious keratitis can lead to blindness. But even prompt initial management with appropriate antimicrobial treatment depends on microorganism sensitivity and resistance. This article presents current data regarding the use of corneal collagen cross-linking in the treatment of corneal infections. This treatment modality may become important, but unanswered questions remain. Larger, prospective comparative studies should provide the answers. UvodVnetni keratitis lahko brez ustreznega antimikrobnega zdravljenja privede do slepote. Tudi če ga odkrijemo v začetni fazi in pravilno zdravimo, lahko napreduje in privede do mehčanja roženice. Zaradi agresivne narave roženičnih patogenov in nevarnosti odpornosti na antibiotike je potrebno razviti nove načine obvladovanja tega hitro napredujočega stanja.1 O prečnem povezovanju kolagenih vlaken roženice z ultravijolično svetlo-

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Surveillance of the Activity of Aminoglycosides and Fluoroquinolones Against Ophthalmic Pathogens from Europe in 2010–2011

Cited by 25 publications

References 18 publications

Update on the epidemiology and antibiotic resistance of ocular infections

Update on the epidemiology and antibiotic resistance of ocular infections

In Vitro Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and In Vivo Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice

Zdravljenje Okužb Roženice S Prečnim Povezovanjem Kolagenih Vlaken

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