Survival Benefit of Traditional Chinese Herbal Medicine (A Herbal Formula for Invigorating Spleen) in Gastric Cancer Patients with Peritoneal Metastasis

Zhao, Lu; Zhao, Aizhi; Zhao, Gang; Xu, Yan; Zhu, Xiaoyan; Cao, Ningning; Zheng, Jianbao; Yang, Jing; Xu, Jianhua

doi:10.1155/2014/625493

Cited by 23 publications

(16 citation statements)

References 28 publications

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“…Traditional cell killing strategies or targeted therapy might be not enough to block the network reactions. TCM, which contains multiple ingredients that can simultaneously act on multiple targets, has long been tested for cancer adjuvant prevention and treatment due to its systematic regulation on immune function [22][23][24][25][26]. Multiple studies have demonstrated that conventional formulas could inhibit cancer drug resistance or metastasis via regulating T cell phenotype, macrophage polarization, chemokine expression and immune checkpoint [27,28].…”

Section: Discussionmentioning

confidence: 99%

“…Different from traditional chemotherapy drugs and targeted inhibitors, TCM is characterized by holistic regulation and network intervenes [22,23]. Numerous studies demonstrated that TCM formula could not only synergistically enhance the therapeutic efficacy of cytotoxic drugs, but also reduce their side effects [24][25][26]. Moreover, multiple clinical studies approved that the survival period of TCM users is greatly prolonged compared to TCM non-users, which is closely correlated with immunity improvement.…”

Section: Discussionmentioning

confidence: 99%

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XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling

Zheng

Wang

et al. 2020

Cell Commun Signal

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Background: Recent findings suggested that premetastatic niche (PMN) is a prerequisite in mediating cancer metastasis. Previously we demonstrated that XIAOPI formula could inhibit breast cancer lung metastasis via inhibiting tumor associated macrophages (TAMs)-secreted CXCL1. Herein, we aimed to explore the effects of XIAOPI formula on preventing breast cancer PMN formation and its underlying molecular mechanisms.Methods: CXCL1 expression of TAMs was detected by qPCR and Western blotting assay. The influences of XIAOPI formula on the proliferation of TAMs and 4 T1 in the co-culture system were tested by CCK8 or EdU staining. Transwell experiment was applied to determine the effects of XIAOPI formula on the invasion ability of HSPCs and 4 T1. Breast cancer xenografts were built by inoculating 4 T1 cells into the mammary pads of Balb/c mice and lung metastasis was monitored by luciferase imaging. Immune fluorescence assay was used to test the epithelialmesenchymal transition process and PMN formation in the lung tissues. The effects of XIAOPI formula on TAMs phenotype, hematopoietic stem/progenitor cells (HSPCs) and myeloid-derived suppressor cells (MDSCs) were determined by flow cytometry.(Continued on next page)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling

Zheng

Wang

et al. 2020

Cell Commun Signal

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“…Derivatives of anthraquinone family are natural products, which were mainly extracted from rhubarb and used in CHM ( 3 – 5 ). As a palliative treatment, CHM was commonly used with oral administration for different types of cancers in China ( 6 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines

Ren

Dai

et al. 2018

Mol Med Report

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Chrysophanol is an anthraquinone compound, which exhibits anticancer effects on certain types of cancer cells. However, the effects of chrysophanol on human breast cancer remain to be elucidated. The aim of the present study was to clarify the role of chrysophanol on breast cancer cell lines MCF-7 and MDA-MB-231, and to identify the signal transduction pathways regulated by chrysophanol. MTT assay and flow cytometric analysis demonstrated that chrysophanol inhibited cell proliferation, and cell cycle progression in a dose-dependent manner. The expression of cell cycle-associated cyclin D1 and cyclin E were downregulated while p27 expression was upregulated following chrysophanol treatment at the mRNA, and protein levels. The Annexin V/propidium iodide staining assay results revealed that apoptosis levels increased following chrysophanol treatment. Chrysophanol upregulated caspase 3 and poly (ADP-ribose) polymerase cleavage in both cell lines. Furthermore, chrysophanol enhanced the effect of paclitaxel on breast cancer cell apoptosis. In addition, chrysophanol downregulated apoptosis regulator Bcl-2 protein, and transcription factor p65 and IκB phosphorylation. Inhbition of nuclear factor (NF)-κB by ammonium pyrrolidine dithiocarbamate diminished the effect of chrysophanol on apoptosis and associated proteins. In conclusion, the results of the current study demonstrated that chrysophanol effectively suppresses breast cancer cell proliferation and facilitates chemosentivity through modulation of the NF-κB signaling pathway.

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“…Findings of recent studies have demonstrated that many compounds from Traditional Chinese Medicine (TCM) are effective in the treatment of malignant tumors, including HCC (2)(3)(4). In a previous study, we found that Ganzaoning granule, a Traditional Chinese Medicine formula, is able to inhibit diethylnitrosamine-induced hepatocarcinogenesis in rat (5,6).…”

Section: Introductionmentioning

confidence: 99%

Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells

Wang

Cheng

et al. 2014

Oncology Reports

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Diosgenin is a major compound of Dioscoreaceae plants such as yam, which is used as a drug in Traditional Chinese Medicine, and a common vegetable worldwide. The anticancer effect of diosgenin has been reported in various tumor cells, including leukemia, gastric, colorectal, and breast cancer. However, the activity of diosgenin on hepatocellular carcinoma (HCC) and the underlying mechanism have not been completely investigated. Therefore, we investigated the efficacy and associated mechanisms of diosgenin in HCC cells. Flow cytometric analysis was performed to determine the presence of cell cycle arrest and apopotic cells. Diosgenin significantly inhibited the growth of Bel-7402, SMMC-7721 and HepG2 HCC cells in a concentration-dependent manner. Diosgenin treatment for 24 h induced G2/M cell cycle arrest and apoptosis of hepatoma cells. Diosgenin inhibited Akt phosphorylation and upregulated p21 and p27 expression, but did not alter the expression of p53, suggesting diosgenin-induced upregulation of p21 and p57 is p53-independent in HCC cells. Diosgenin induced HCC cell apoptosis by activating caspase cascades -3, -8 and -9. However, diosgenin did not affect Bcl-2 and Bax levels. In conclusion, results of the present study suggest that diosgenin may be an active anti-HCC agent obtained from natural plants and provide new insights in understanding the mechanisms of diosgenin.

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Survival Benefit of Traditional Chinese Herbal Medicine (A Herbal Formula for Invigorating Spleen) in Gastric Cancer Patients with Peritoneal Metastasis

Cited by 23 publications

References 28 publications

XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling

XIAOPI formula inhibits the pre-metastatic niche formation in breast cancer via suppressing TAMs/CXCL1 signaling

Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines

Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells

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