Susceptibility to Nausea and Motion Sickness as a Function of the Menstrual Cycle

Matchock, Robert L.; Levine, Murray D.; Gianaros, Peter J.; Stern, Robert M.

doi:10.1016/j.whi.2008.01.006

Cited by 51 publications

(26 citation statements)

References 38 publications

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“…The effectiveness of the stimulus may be related to its novelty. Susceptible individuals typically develop motion sickness within a few minutes of exposure to the moving visual field inside an optokinetic drum (Bos et al, 2004; Bubka et al, 2006; Dahlman et al, 2009; Matchock et al, 2008). Motion sickness during vehicular travel, such as seasickness, can evolve slowly over time (Lackner, 2014; Lawther et al, 1988; Wertheim, 1998), resulting in different physiological responses and sensations than those during an acute response to a highly provocative stimulus.…”

Section: Prodromal Physiological Changes: Potential Physiological mentioning

confidence: 99%

What is nausea? A historical analysis of changing views

Balaban

Yates

2017

Autonomic Neuroscience

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The connotation of “nausea” has changed across several millennia. The medical term ‘nausea’ is derived from the classical Greek terms ναυτια and ναυσια, which designated the signs and symptoms of seasickness. In classical texts, nausea referred to a wide range of perceptions and actions, including lethargy and disengagement, headache (migraine), and anorexia, with an awareness that vomiting was imminent only when the condition was severe. However, some recent articles have limited the definition to the sensations that immediately precede emesis. Defining nausea is complicated by the fact that it has many triggers, and can build-up slowly or rapidly, such that the prodromal signs and symptoms can vary. In particular, disengagement responses referred to as the “sopite syndrome” are typically present only when emetic stimuli are moderately provocative, and do not quickly culminate in vomiting or disengagement from the triggering event. This review considers how the definition of “nausea” has evolved over time, and summarizes the physiological changes that occur prior to vomiting that may be indicative of nausea. Also described are differences in the perception of nausea, as well as the accompanying physiological responses, that occur with varying stimuli. This information is synthesized to provide an operational definition of nausea.

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Section: Prodromal Physiological Changes: Potential Physiological mentioning

confidence: 99%

What is nausea? A historical analysis of changing views

Balaban

Yates

2017

Autonomic Neuroscience

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“…Menstrual cycle was held constant to preclude influences on motion sickness because of hormonal variability (24,25). All participants were tested in the morning between 0700 and 1200 hours, and fasted for at least 6 hours before the test; compliance with the fasting instruction was tested with glucose sticks (G110 mg/dl).…”

Section: Experiments 1: Variation Of Rotation Speedmentioning

confidence: 99%

Reduction of Motion Sickness With an Enhanced Placebo Instruction

Horing

Weimer

Schrade

et al. 2013

Psychosomatic Medicine

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“…Women are also known to be less susceptible to seasickness at the day of ovulation and when taking contraceptive pills [16].…”

Section: Methodsmentioning

confidence: 99%

Impact of oral vitamin C on histamine levels and seasickness

Jarisch¹,

Weyer²,

Ehlert³

et al. 2014

VES

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BACKGROUND: Seasickness is a risk aboard a ship. Histamine is postulated as a causative agent, inversely related to the intake of vitamin C. Persons with mastocytosis experienced improvement of nausea after the intake of vitamin C. OBJECTIVE: To determine whether vitamin C suppresses nausea in 70 volunteers who spent 20 minutes in a life raft, exposed to one-meter-high waves in an indoor pool. METHOD: Double-blind placebo-controlled crossover study. Two grams of vitamin C or placebo was taken one hour before exposure. Blood samples were taken one hour before and after exposure to determine histamine, diamine oxidase, tryptase, and vitamin C levels. Symptom scores were noted on a visual analog scale. On the second day the test persons were asked which day they had felt better. RESULTS: Seven persons without symptoms were excluded from the analysis. Test persons had less severe symptoms after the intake of vitamin C (p < 0.01). Scores on the visual analog scale were in favor of vitamin C, but the difference was not significant. Twenty-three of 63 persons wished to leave the raft earlier: 17 after the intake of placebo and 6 after the intake of vitamin C (p < 0.03). Women (p < 0.02) and men below 27 years of age (p < 0.02) had less pronounced symptoms after the intake of vitamin C. Histamine (p < 0.01) and DAO levels were increased after the intake of vitamin C (p < 0.001) and after placebo (n.s.). The fact that the second test day was rated less stressful by most volunteers is indicative of habituation. CONCLUSIONS: Some of the data show that vitamin C is effective in suppressing symptoms of seasickness, particularly in women and men younger than 27 years of age, and is devoid of side effects. Histamine levels were initially increased after the test persons had been exposed to waves.

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Susceptibility to Nausea and Motion Sickness as a Function of the Menstrual Cycle

Cited by 51 publications

References 38 publications

What is nausea? A historical analysis of changing views

What is nausea? A historical analysis of changing views

Reduction of Motion Sickness With an Enhanced Placebo Instruction

Impact of oral vitamin C on histamine levels and seasickness

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