This chapter explores recent advancements in materials driving innovation within air conditioning technologies. Traditional materials face limitations in efficiency and sustainability, prompting a shift toward novel solutions. Nanostructured materials, with their enhanced heat transfer properties, are gaining prominence, alongside advanced heat exchanger materials offering superior performance and durability. Sustainability is prioritized through the adoption of eco-friendly materials and smart technologies. Shape memory alloys and smart materials enable adaptive systems for optimized comfort and energy efficiency. While challenges persist in cost and scalability, interdisciplinary efforts are propelling the field toward a future of greener, more efficient air conditioning solutions.