Sustainable inflammatory activation following spinal cord injury is driven by thrombin-mediated dynamic expression of astrocytic chemokines

He, Bingqiang; Niu, Li; Li, Shaolan; Li, Hui; Hou, Yuxuan; Li, Aicheng; Zhang, Xingyuan; Hao, Huifei; Song, Honghua; Cai, Rixin; Zhou, Yue; Wang, Yingjie; Wang, Yongjun

doi:10.1016/j.bbi.2023.11.035

Cited by 6 publications

(1 citation statement)

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“…At the molecular level, the release of inflammatory cytokines, including interleukin (IL)-1a, IL-1b, IL-6, and tumor necrosis factor (TNF), recruits immune cells to the injury site and initiates the inflammatory cascade. This inflammatory response leads to further damage and cell death within the spinal cord [ 14 , 15 ].…”

Section: Pathophysiology Of Scimentioning

confidence: 99%

The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

Li,

Luo,

2024

Stem Cell Res Ther

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Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive disabilities of sensory, motor and autonomic functions. To date, limitations in current clinical treatment options can leave SCI patients with lifelong disabilities. There is an urgent need to develop new therapies for reconstructing the damaged spinal cord neuron-glia network and restoring connectivity with the supraspinal pathways. Neural stem cells (NSCs) possess the ability to self-renew and differentiate into neurons and neuroglia, including oligodendrocytes, which are cells responsible for the formation and maintenance of the myelin sheath and the regeneration of demyelinated axons. For these properties, NSCs are considered to be a promising cell source for rebuilding damaged neural circuits and promoting myelin regeneration. Over the past decade, transplantation of NSCs has been extensively tested in a variety of preclinical models of SCI. This review aims to highlight the pathophysiology of SCI and promote the understanding of the role of NSCs in SCI repair therapy and the current advances in pathological mechanism, pre-clinical studies, as well as clinical trials of SCI via NSC transplantation therapeutic strategy. Understanding and mastering these frontier updates will pave the way for establishing novel therapeutic strategies to improve the quality of recovery from SCI.

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Section: Pathophysiology Of Scimentioning

confidence: 99%