2015
DOI: 10.1016/j.neulet.2015.07.029
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Sustained Arc expression in adult-generated granule cells

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Cited by 9 publications
(10 citation statements)
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“…These effects indicate that the blades of the DG show unique responses to brief spatial experience, consistent with previous literature [6, 7, 9, 19]. Although no main effect of genotype was observed ( F 1,138  = 0.13; p = 0.72), a significant genotype by behavioral group interaction ( F 4,138  = 6.29; p < 0.0001) was observed.…”
Section: Resultssupporting
confidence: 91%
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“…These effects indicate that the blades of the DG show unique responses to brief spatial experience, consistent with previous literature [6, 7, 9, 19]. Although no main effect of genotype was observed ( F 1,138  = 0.13; p = 0.72), a significant genotype by behavioral group interaction ( F 4,138  = 6.29; p < 0.0001) was observed.…”
Section: Resultssupporting
confidence: 91%
“…As previously reported [6, 7, 9, 19], this brief exposure results in an increase in the number of granule cells expressing Arc in WT mice that perdures for at least 8 hours. However, by 240 min after exposure, the levels of Arc are reduced significantly more in the Egr3 −/− mice than their WT littermates, and this effect persists at 480 min.…”
Section: Resultssupporting
confidence: 73%
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“…On the other hand, the results indicated that DG is more sensitive to BPA. The possible explanation of the DG sensitivity is that BPA may negatively affect neurogenesis in DG3441 and Arc has been reported to be continually expressed in new-born granule cells42. To our knowledge, this is the first report showing that Arc was implicated in BPA induced impaired dendrite and spine formation and spatial memory deficits.…”
Section: Discussionmentioning
confidence: 81%
“…Activity‐regulated cytoskeleton‐associated protein (Arc) is an immediate early gene induced by a variety of conditions including seizures, exploration of novel environments, and spatial learning (Lyford, et al, ; Ramírez‐Amaya et al, ; Messaoudi et al, ; Farris et al, ) all of which activate hippocampal neurons. Basal Arc contents are very low, thus its presence has been widely used as a neuronal activity marker for in vivo analysis of robust neuronal activation (Toyoda et al, ) and for neural activity associated to several types of behavioral experiences (Vazdarjanova et al, , Ramirez‐Amaya et al, ; Carasatorre et al, ; Meconi et al, ).…”
mentioning
confidence: 99%