2022
DOI: 10.1038/s41386-022-01361-x
|View full text |Cite
|
Sign up to set email alerts
|

Sustained effects of single doses of classical psychedelics in humans

Abstract: The serotonergic classical psychedelics include compounds that primarily activate the brain’s serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca). The acute effects of these compounds are well-known as are their ability to increase the emotional state both in healthy people and in those with neuropsychiatric disorders. In particular psilocybin, the psychoactive constituent in “magic mushrooms”, has shown great potential for treatment of anxiety and depression. A unique and compelling… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
21
0
1

Year Published

2022
2022
2024
2024

Publication Types

Select...
6
3
1

Relationship

0
10

Authors

Journals

citations
Cited by 34 publications
(22 citation statements)
references
References 65 publications
0
21
0
1
Order By: Relevance
“…The 5-HT 2A receptor is the primary site of the action of 5-HTergic hallucinogens, such as LSD, psilocybin, mescaline, currently recognized as fast acting antidepressants [ 133 ]. Depressive-like behavior was not affected in mice with global knockout of 5-HT 2A receptor [ 134 ].…”
Section: The 5-ht 2 Receptor Familymentioning
confidence: 99%
“…The 5-HT 2A receptor is the primary site of the action of 5-HTergic hallucinogens, such as LSD, psilocybin, mescaline, currently recognized as fast acting antidepressants [ 133 ]. Depressive-like behavior was not affected in mice with global knockout of 5-HT 2A receptor [ 134 ].…”
Section: The 5-ht 2 Receptor Familymentioning
confidence: 99%
“…A variety of pathways and immediate early genes related to cell growth are upregulated by psychedelics, including brain-derived neurotrophic factor (BDNF) ( Olson, 2022 ). BDNF has been repeatedly suggested to be the key effector in inducing neuroplasticity and thus lasting changes in cognition and behavior ( Perkins et al, 2021 ; Knudsen, 2022 ; Olson, 2022 ). This is, for example, underlined by the fact that the anti-depressive effects of the dissociative ketamine, which displays therapeutic effects similar to psychedelics, are blocked by BDNF knockout in mice ( Autry et al, 2011 ).…”
Section: Effects Of Psychedelics – Prefrontal Plasticitymentioning
confidence: 99%
“…Currently, it is unclear how behavioural interventions could profit from or interact with psychedelic-induced effects on mitochondria. Effects on mitochondria-related sensations of energy (Filippi et al, 2022), intero- and exteroception (Picard, 2022) and neuronal plasticity (Cheng et al, 2010) could support psychotherapy and health behaviour changes (Knudsen, 2022; Teixeira et al, 2022). The interplay between psychedelics, psychotherapy and mitochondria needs to be investigated in future studies.…”
Section: Limitations and Future Researchmentioning
confidence: 99%