Sustained heparin release actuator achieved from thermal and water activated shape memory hydrogels containing main-chain LC units

Guo, Huilong; Dai, Wanting; Miao, Ying; Wang, Yongzhou; Ma, Dong; Wang, Xue

doi:10.1016/j.cej.2018.02.009

Cited by 22 publications

(7 citation statements)

References 36 publications

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“…The cytotoxic properties of the hydrogel with or without PDA NPs toward L929 cells (mouse fibroblasts) were assessed by the CCK-8 assay following the methods published in our previous literature. ,, …”

Section: Methodsmentioning

confidence: 99%

Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing

et al. 2022

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The development of multifunctional injectable adhesive hydrogels with self-healing capacity, shape adaptability, on-demand removability, and excellent photothermal antibacterial activity to promote bacteria-infected wound healing is highly recommended in practical applications. In this work, an injectable adhesive self-healing multiple-dynamic-bond crosslinked hydrogel was formed by a multiple-dynamic-bond crosslinked network of dynamic borate/didiol interactions, hydrogen bonding, and Schiff base bond. The introduction of Mussel-inspired catechol groups into the hydrogels could endow tissues with adhesive properties, and the hydrogel could adhere well to the skin under water with good shape adaptability under bent and twisted states. The mechanical and adhesive properties improved through the introduction of borate/didiol interactions into the catechol-modified hydrogel with dynamic Schiff base crosslinking at low cost and easy preparation, and the adhesive hydrogel could be removed without second damage to the wound. Moreover, polydopamine nanoparticles (PDA NPs) were introduced into the hydrogels through Schiff base reactions between the quinone group on PDA NPs and the primary amine in glycol chitosan (GC), resulting in an efficient photothermal antibacterial activity with uniformly dispersed PDA NPs in the hydrogel. And the hydrogels illustrated good cytocompatibility and hemocompatibility. Finally, they could be injected to fully fill irregular wounds and significantly promote bacteria-infected wound healing by reducing the inflammatory response, accelerating collagen deposition, and promoting blood vessel reconstruction. Therefore, this demonstrated their superiority in serving as multifunctional dressings for treating a bacteria-infected wound.

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Section: Methodsmentioning

confidence: 99%

Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing

et al. 2022

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“…The cytotoxicity of the HA-CHO/GC/FeCl 3 hydrogels with or without ginsenoside Rg1 and amelogenin toward human bone marrow mesenchymal cells (HBMSCs) was evaluated by the CCK-8 assay, , which was performed in 24-well chambers. Hydrogels (100 μL) with or without drugs were moved into the upper cell culture insert and maintained at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

Injectable and Self-Healing Hydrogels with Double-Dynamic Bond Tunable Mechanical, Gel–Sol Transition and Drug Delivery Properties for Promoting Periodontium Regeneration in Periodontitis

Guo

Huang

Yang

et al. 2021

ACS Appl. Mater. Interfaces

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Injection of a hydrogel loaded with drugs with simultaneous anti-inflammatory and tissue regenerating properties can be an effective treatment for promoting periodontal regeneration in periodontitis. Nevertheless, the design and preparation of an injectable hydrogel with self-healing properties for tunable sustained drug release is still highly desired. In this work, polysaccharidebased hydrogels were formed by a dynamic cross-linked network of dynamic Schiff base bonds and dynamic coordination bonds. The hydrogels showed a quick gelation process, injectability, and excellent self-healing properties. In particular, the hydrogels formed by a double-dynamic network would undergo a gel−sol transition process without external stimuli. And the gel−sol transition time could be tuned by the double-dynamic network structure for in situ stimuli involving a change in its own molecular structure. Moreover, the drug delivery properties were also tunable owing to the gel−sol transition process. Sustained drug release characteristics, which were ascribed to a diffusion process, were observed during the first stage of drug release, and complete drug release owing to the gel−sol transition process was achieved. The sustained drug release time could be tuned according to the double-dynamic bonds in the hydrogel. The CCK-8 assay was used to evaluate the cytotoxicity, and the result showed no cytotoxicity, indicating that the injectable and self-healing hydrogels with double-dynamic bond tunable gel−sol transition could be safely used in controlled drug delivery for periodontal disease therapy. Finally, the promotion of periodontal regeneration in periodontitis in vivo was investigated using hydrogels loaded with ginsenoside Rg1 and amelogenin. Micro-CT and histological analyses indicated that the hydrogels were promising candidates for addressing the practical needs of a tunable drug delivery method for promoting periodontal regeneration in periodontitis.

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“…Lyotropic liquid crystals experience phase transitions as a function of liquid crystal concentration in a solvent and temperature change 29 . These characteristics are currently exploited for shape memory effects in many LCE systems 30,31 …”

Section: Introductionmentioning

confidence: 99%

“…29 These characteristics are currently exploited for shape memory effects in many LCE systems. 30,31 In the last few decades, many technologies have been developed…”

mentioning

confidence: 99%

Shape memory elastomers: A review of synthesis, design, advanced manufacturing, and emerging applications

Prathumrat

Nikzad

Hajizadeh

et al. 2022

Polymers for Advanced Techs

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Shape memory elastomers (SMEs) are a class of intelligent materials characterized by their ability to deform and recover shapes under applied force and external stimuli. Heat and ultraviolet radiation are examples of the most common external stimuli. With the emerging prevalence of internet of things devices and the ensuing need for smart materials and structures, SMEs provide significant opportunities to support the development of novel applications in robotics, remotely actuated systems, and packages, including those promised for the space industry. To harness the immense potential in the emerging applications of these materials, one approach is the systematic multi‐scale modeling coupled with artificial intelligence‐assisted design leading to the development of next‐generation intelligent systems. This review covers several aspects of the synthesis/materials chemistry and applications of SMEs with a view towards enabling such an approach. The synthesis procedures emphasizing dynamic covalent bond reactions are reviewed. Then, liquid crystalline elastomers are introduced as a specific elastomeric material class that exhibits excellent shape memory characteristics and distinctive transition temperatures. The utilization of advanced manufacturing methods such as additive manufacturing, three‐dimensional printing, and the emerging four‐dimensional printing technologies assisted by machine learning are detailed in producing and predicting SMEs. Finally, the current trends in the use of SMEs are summarized in areas of industrial and space engineering and biomedical applications.

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Sustained heparin release actuator achieved from thermal and water activated shape memory hydrogels containing main-chain LC units

Cited by 22 publications

References 36 publications

Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing

Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing

Injectable and Self-Healing Hydrogels with Double-Dynamic Bond Tunable Mechanical, Gel–Sol Transition and Drug Delivery Properties for Promoting Periodontium Regeneration in Periodontitis

Shape memory elastomers: A review of synthesis, design, advanced manufacturing, and emerging applications

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