Sustained-release alginate-chitosan pellets prepared by melt pelletization technique

Wong, Tin Wui; Harjoh, Nurulaini

doi:10.3109/03639045.2011.653364

Cited by 12 publications

(4 citation statements)

References 34 publications

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“…The solution viscosity of the modified chitosan was determined using an already reported method [47]. Briefly, a 0.5% (w/w) solution of each chitosan sample was prepared in 2% (v/v) acetic acid and filled into a U-tube viscometer (Ostwalds Viscometer, Zhejiang, China).…”

Section: Specific Viscosity (Sv)mentioning

confidence: 99%

Formulation and Evaluation of Microwave-Modified Chitosan-Curcumin Nanoparticles—A Promising Nanomaterials Platform for Skin Tissue Regeneration Applications Following Burn Wounds

Basit

Amin

et al. 2020

Polymers

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Improved physicochemical properties of chitosan-curcumin nanoparticulate carriers using microwave technology for skin burn wound application are reported. The microwave modified low molecular weight chitosan variant was used for nanoparticle formulation by ionic gelation method nanoparticles analyzed for their physicochemical properties. The antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa cultures, cytotoxicity and cell migration using human dermal fibroblasts—an adult cell line—were studied. The microwave modified chitosan variant had significantly reduced molecular weight, increased degree of deacetylation and decreased specific viscosity. The nanoparticles were nano-sized with high positive charge and good dispersibility with entrapment efficiency and drug content in between 99% and 100%, demonstrating almost no drug loss. Drug release was found to be sustained following Fickian the diffusion mechanism for drug release with higher cumulative drug release observed for formulation (F)2. The microwave treatment does not render a destructive effect on the chitosan molecule with the drug embedded in the core of nanoparticles. The optimized formulation precluded selected bacterial strain colonization, exerted no cytotoxic effect, and promoted cell migration within 24 h post application in comparison to blank and/or control application. Microwave modified low molecular weight chitosan-curcumin nanoparticles hold potential in delivery of curcumin into the skin to effectively treat skin manifestations.

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Section: Specific Viscosity (Sv)mentioning

confidence: 99%

Formulation and Evaluation of Microwave-Modified Chitosan-Curcumin Nanoparticles—A Promising Nanomaterials Platform for Skin Tissue Regeneration Applications Following Burn Wounds

Basit

Amin

et al. 2020

Polymers

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“…The calcium content of melt pellets undergoing drug dissolution was examined using atomic absorption spectrophotometry technique (Z-2000, Hitachi Hi-Technologies Corporation, Japan), adopting a previously reported protocol (Wong and Nurulaini, 2012). It was calculated from the difference between total calcium content of pellets and amount of calcium released in dissolution medium at specific intervals.…”

Section: Calcium Contentmentioning

confidence: 99%

“…The dispersed fragments, though exhibiting a larger specific surface area for drug dissolution than intact matrix, are rapidly crosslinked and consolidated by soluble Ca 2+ from calcium acetate and have drug release retarded. In another study of sustained-release alginate pellets prepared by melt pelletization technique, the chitosan instead of calcium acetate is used to coacervate with alginate into polyelectrolyte complexes (Wong and Nurulaini, 2012). The slow drug release characteristics are a resultant effect of pellet aggregation into swollen structures with reduced erosion.…”

Section: Introductionmentioning

confidence: 99%

Melt pelletization of alginate: Effects of air pressurization on consolidation and drug release property of pellets

Hanafi

Wong

2015

Chemical Engineering Research and Design

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“…Chitosan is a linear randomly distributed, binary heteropolysaccharide consisting of β(1‐4) linked 2‐acetamido‐2‐deoxy‐β‐D‐glucopyranose and 2‐amino‐2‐deoxy‐β‐D‐glycopyranose units (Wong, ; Wong & Harjoh, ; Yong & Wong, ). It is a natural, biodegradable and biocompatible polymer which lacks irritant and allergic effects.…”

Section: Introductionmentioning

confidence: 99%

Quantitative characterization of chitosan in the skin by Fourier‐transform infrared spectroscopic imaging and ninhydrin assay: application in transdermal sciences

Nawaz

Wong

2015

Journal of Microscopy

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The chitosan has been used as the primary excipient in transdermal particulate dosage form design. Its distribution pattern across the epidermis and dermis is not easily accessible through chemical assay and limited to radiolabelled molecules via quantitative autoradiography. This study explored Fourier-transform infrared spectroscopy imaging technique with built-in microscope as the means to examine chitosan molecular distribution over epidermis and dermis with the aid of histology operation. Fourier-transform infrared spectroscopy skin imaging was conducted using chitosan of varying molecular weights, deacetylation degrees, particle sizes and zeta potentials, obtained via microwave ligation of polymer chains at solution state. Both skin permeation and retention characteristics of chitosan increased with the use of smaller chitosan molecules with reduced acetyl content and size, and increased positive charge density. The ratio of epidermal to dermal chitosan content decreased with the use of these chitosan molecules as their accumulation in dermis (3.90% to 18.22%) was raised to a greater extent than epidermis (0.62% to 1.92%). A larger dermal chitosan accumulation nonetheless did not promote the transdermal polymer passage more than the epidermal chitosan. A small increase in epidermal chitosan content apparently could fluidize the stratum corneum and was more essential to dictate molecular permeation into dermis and systemic circulation. The histology technique aided Fourier-transform infrared spectroscopy imaging approach introduces a new dimension to the mechanistic aspect of chitosan in transdermal delivery.

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Sustained-release alginate-chitosan pellets prepared by melt pelletization technique

Cited by 12 publications

References 34 publications

Formulation and Evaluation of Microwave-Modified Chitosan-Curcumin Nanoparticles—A Promising Nanomaterials Platform for Skin Tissue Regeneration Applications Following Burn Wounds

Formulation and Evaluation of Microwave-Modified Chitosan-Curcumin Nanoparticles—A Promising Nanomaterials Platform for Skin Tissue Regeneration Applications Following Burn Wounds

Melt pelletization of alginate: Effects of air pressurization on consolidation and drug release property of pellets

Quantitative characterization of chitosan in the skin by Fourier‐transform infrared spectroscopic imaging and ninhydrin assay: application in transdermal sciences

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