Sustained Release Microneedles: Materials and Applications in Facial Rejuvenation

Huang, Xiaoqi; Chang, Qiang; Gao, Jianhua; Lu, Feng

doi:10.1089/ten.teb.2022.0131

Cited by 3 publications

(2 citation statements)

References 73 publications

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“…Its efficacy stems from its ability to create small injuries and initiate the wound healing process, which in turn leads to neocollagenesis. 96 In pursuit of enhancing the treatment efficacy of skin photoaging, Xiuli Wang's research team explored the use of roller microneedles for delivering adipose-derived stem cell-derived extracellular vesicles (ADSC-EVs) to the skin. 97 Their findings validated that microneedles are an effective means of delivering drugs to the skin, thereby improving treatment outcomes.…”

Section: Biomaterials Strengthen Anti Photoaging Effects Of Evsmentioning

confidence: 99%

Advances in the Applications of Extracellular Vesicle for the Treatment of Skin Photoaging: A Comprehensive Review

Cai,

He,

2023

IJN

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Skin photoaging is a complex biological process characterized by the accumulation of oxidative damage and structural changes in the skin, resulting from chronic exposure to ultraviolet (UV) radiation. Despite the growing demand for effective treatments, current therapeutic options for skin photoaging remain limited. However, emerging research has highlighted the potential of extracellular vesicles (EVs), including exosomes, micro-vesicles, apoptotic bodies and liposomes, as promising therapeutic agents in skin rejuvenation. EVs are involved in intercellular communication and can deliver bioactive molecules, including proteins, nucleic acids, and lipids, to recipient cells, thereby influencing various cellular processes. This comprehensive review aims to summarize the current research progress in the application of EVs for the treatment of skin photoaging, including their isolation and characterization methods, roles in skin homeostasis, therapeutic potential and clinical applications for skin photoaging. Additionally, challenges and future directions in EVs-based therapies for skin rejuvenation are discussed.

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Section: Biomaterials Strengthen Anti Photoaging Effects Of Evsmentioning

confidence: 99%

Advances in the Applications of Extracellular Vesicle for the Treatment of Skin Photoaging: A Comprehensive Review

Cai,

He,

2023

IJN

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“…Both the parameters of the process and the chemical composition of the resins used to manufacture microneedles affect their final geometry [12]. There are five basic types of microneedles: solid, hollow, coated, dissolvable and hydrogel-type [13]. The DLP method is known to be used to obtain microneedle systems using, for example, polyethylene glycol diacrylate (PEGDA) as the matrix and the drug diclofenac sodium [14] or gelatin methacryloyl and the drug amoxicillin [15], where PEGDA and gelatin methacryloyl swell, enabling drug release by diffusion.…”

Section: Introductionmentioning

confidence: 99%

Photopolymer-Based Composite with Substance Release Capability Manufactured Additively with DLP Method

Tomczak,

Borysiak,

Kuczko

et al. 2024

Materials

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In this study, caffeine-loaded photoresin composites with homogeneous structures, suitable for additive manufacturing of transdermal microneedle systems, were obtained. The properties of the composites with varying caffeine concentrations (0.1–0.4% w/w) were investigated for carbon–carbon double bond conversion using Fourier Transform Infrared Spectroscopy, surface wettability and mechanical properties using a static tensile test and nanoindentation, and caffeine release in ethanol using UV-Vis. The caffeine concentration did not affect the final degree of double bond conversion, which was confirmed in tensile tests, where the strength and Young’s modulus of caffeine-loaded samples had comparable values to control ones. Samples with 0.1 and 0.2% caffeine content showed an increase in nanohardness and reduced elastic modulus of 50 MPa and 1.5 MPa, respectively. The good wettability of the samples with water and the increase in surface energy is a favorable aspect for the dedicated application of the obtained composite materials. The amount of caffeine released into the ethanol solution at 1, 3 and 7 days reached a maximum value of 81%, was higher for the lower concentration of caffeine in the sample and increased over time. The conducted research may enhance the potential application of composite materials obtained through the digital light processing method in additive manufacturing.

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Cutting-edge developments in the application of hydrogels for treating skin photoaging

Cao,

Qian,

Min

et al. 2024

Front. Mater.

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Skin photoaging, caused by prolonged exposure to ultraviolet (UV) radiation, manifests as intricate biological transformations, encompassing oxidative damage and structural alterations. Despite a growing need for effective interventions, the existing therapeutic repertoire for treating skin photoaging remains constrained. Recent investigations have shifted focus towards the application of hydrogels as a novel avenue for addressing this concern. Various active substances can be combined with hydrogels for transdermal delivery, including compounds from the ocean, plants, cell active substances, which can promote skin UV damage repair mainly through antioxidant, anti-inflammatory and promote collagen production. This review seeks to offer a thorough summary of recent progress in employing hydrogels for addressing skin photoaging. Topics covered include the mechanism of skin photoaging, and emerging trends in hydrogel-based therapies for skin rejuvenation. The discussion also explores challenges and outlines potential future directions in leveraging hydrogels as therapeutic agents to address skin photoaging.

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Sustained Release Microneedles: Materials and Applications in Facial Rejuvenation

Cited by 3 publications

References 73 publications

Advances in the Applications of Extracellular Vesicle for the Treatment of Skin Photoaging: A Comprehensive Review

Advances in the Applications of Extracellular Vesicle for the Treatment of Skin Photoaging: A Comprehensive Review

Photopolymer-Based Composite with Substance Release Capability Manufactured Additively with DLP Method

Cutting-edge developments in the application of hydrogels for treating skin photoaging

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