Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

Abstract

Electrospinning is an economical and alluring method to fabricate wound dressing mats from a variety of natural and synthetic materials. In this study, polyvinylidene fluoride (PVDF) and starch composite mats containing ciprofloxacin (CIP) loaded on titanium dioxide nanoparticles (TiO 2 ) were prepared. Fourier Transform Infrared spectra of CIP, synthesized TiO 2 NPs, TiO 2 /CIP, and PVDF/starch composite mats are analyzed. Scanning electron microscopy images revealed that the fiber diameter of PVDF nanofibers thickens by increasing starch, which varies between 180 nm and 550 nm. Strain at break of PVDF, starch, PVDF/starch (2:1 w:w; P2S1), PVDF/starch (1:1 w:w; P1S1), PVDF/starch (1:2 w:w; P1S2), and nanofibers were 103 AE 11, 3 AE 0.6, 27 AE 4, 52 AE 5.2, 7.7 AE 1%, respectively. Based on strain at break and young modulus, P2S1 was selected as a suitable candidate for wound dressing to which load TiO 2 / CIP as a bioactive agent. The release rate of CIP showed that about 40% of the drug is released in the first 2 days. Furthermore, the antibacterial activity of dressings was investigated using Escherichia coli and Staphylococcus aureus microorganisms and zones of clearance were obvious around the specimen on the agar plate.

Electrospun PVDF Nanofibers for Piezoelectric Applications: A Review of the Influence of Electrospinning Parameters on the β Phase and Crystallinity Enhancement

“…A high surface area of nanofibers provides modifications on bioactivity (e.g., increase of the cell proliferation), electroactivity, strength, etc. The applications of nanofibers cover various aspects, such as filter materials [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ], electronic technology (e.g., nanoelectronics, optical sensors, battery electrode materials, and capacitors) [ 40 , 41 , 42 , 43 , 44 , 45 ], biomedical science (e.g., such as tissue engineering and drug delivery) [ 46 , 47 , 48 , 49 ], and catalyst supports [ 50 , 51 ]. There are different methods based on the top-down or bottom-up approaches to produce nanofibers, as shown in Figure 1 .…”

Photocatalytic TiO2-Based Nanostructured Materials for Microbial Inactivation

“…Antibacterial behavior is strongly desirable in this kind of material to prevent infections during wound recovery [163], [164]. A great deal of work has been carried out in the development of biocompatible TiO2-NPs-based nanocomposites, with intrinsic antimicrobial activity, specifically designed for tissue engineering-related applications to be used in healthcare facilities [33,[165][166][167][168][169].…”

Scaffold-Based Poly(Vinylidene Fluoride) and Its Copolymers: Materials, Fabrication Methods, Applications, and Perspectives

“…Compared with pure PVDF, culturing human dermal fibroblasts on PVA/PVDF scaffolds can achieve higher cell adhesion and proliferation, thanks to the hydrophilicity of PVA . In terms of antibacterial properties, antibacterial drugs (norfloxacin, ciprofloxacin) are incorporated into PVDF to meet this requirement. , …”