Sutureless tympanoplasty using acellular dermis

Raj, Anuradha; Sayal, Ankush; Rathore, Praveen Kumar; Meher, Ravi

doi:10.1016/j.amjoto.2009.10.007

Cited by 19 publications

(20 citation statements)

References 11 publications

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“…Although the closure rate of these grafts such as autografts, allografts, synthetic, and biomaterial grafts have been reported of up to 80–90%, none yet has superiority for repair of all types of perforations due to its own disadvantages 3, 6–10, 20–23. For instance, TM closure rate of autologous grafts has been reported of about 80–97% for temporalis fascia, 71–97% for perichondrium and cartilage, and 86% for fat, which are the most commonly used autografts followed by vein, dura mater, periostum, subcutaneous tissue, and skin 1, 8, 20, 24–27. However, preparation of these autologous grafts needs an extra surgical procedure that imposes surgical and anesthetic risks to the patients along with longer procedure times and subsequent scar tissue on the skin.…”

Section: Discussionmentioning

confidence: 99%

“…Allografts like acellular dermis or dura with acceptable closure rates of 78–95% also have their own disadvantages such as requiring decellularizing procedures to reduce immunogenicity and screening for a wide range of viral or other contagious infections 8, 28…”

Section: Discussionmentioning

confidence: 99%

“…In addition, these materials are comparable with each other due to their production process difficulties and costs along with their ability to support fibroblast adhesion and proliferation and subsequent complete repair of the TM perforation 3, 6–9, 20–23…”

Section: Discussionmentioning

confidence: 99%

“…However, in recent decades, several studies have focused on type I tympanoplasty reconstruction techniques using various graft materials rather than expensive, complex, and high‐risk operative approaches with long hospitalization periods 1, 2. Since 1878, a variety of materials such as autologous and allografts, paper patches, synthetic and bioabsorbable materials, composite materials, and, lately, cell‐seeded and tissue‐ engineered grafts have been used for TM grafting 3–9. The current concern is which composite materials and biomaterials are the best bases and scaffolds regarding high susceptibility to support cell adhesion, proliferation, and differentiation, as well as their ability to promote tissue repair in vivo and consequently repair the perforation 6, 10–14.…”

Section: Introductionmentioning

confidence: 99%

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Collagen‐immobilized patch for repairing small tympanic membrane perforations: In vitro and in vivo assays

Farhadi

Mirzadeh

Solouk

et al. 2011

J Biomedical Materials Res

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Tympanic membrane (TM) perforation is still one of the most common otology complications. New designs of biomaterials, and lately tissue-engineered composites and grafts, have thoroughly revolutionized the management of TM perforation. In this study, we examined a biologically modified collagen-immobilized polydimethyl siloxane patch to repair TM perforation. In vitro potential of the aforementioned patch as a scaffold to support fibroblast cell growth and adhesion was assessed. An in vivo assay of the patch for initiating repair of TM perforations also was investigated. In vitro assay showed that the patch has significantly increased cell adhesion and growth in comparison with unmodified ones (p < 0.05). In vivo study also showed an overall closure rate of TM perforation of 70% and an average gain of 15.75 ± 4.29 dB in air-bone gap. This study shows that the preliminary in vivo evaluation of a modified siloxane patch in humans had promising results and is comparable to existing biomaterial patches.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Collagen‐immobilized patch for repairing small tympanic membrane perforations: In vitro and in vivo assays

Farhadi

Mirzadeh

Solouk

et al. 2011

J Biomedical Materials Res

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show abstract

“…ADM is a biological material that has been mainly used to repair small defects in otorhinolaryngology-head and neck surgery, such as nasal septal mucosal defects, 12 anterior skull base defects, 13 tympanoplasty, 14 and reconstruction of defects from head and neck tumors. 11 , 15 - 17 Li et al.…”

Section: Discussionmentioning

confidence: 99%

Traumatic laryngotracheal stenosis treated by hyoid–sternohyoid osseomuscular flap combined with xenogenic acellular dermal matrix: A case report and literature review

et al. 2017

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ObjectiveThe treatment of laryngotracheal stenosis is a major therapeutic challenge. Various treatments include observation, medical management, and surgical management. The most effective surgical management is resection and reconstruction. To the authors’ knowledge, no reports have described the use of xenogenic acellular dermal matrix (ADM) for laryngotracheal stenosis.MethodsA 27-year-old man presented with hemoptysis of the neck due to a traffic accident. Emergency orotracheal intubation was performed. Tracheostomy was then performed under local anesthesia. Computed tomography revealed fractures of the right thyroid cartilage and posterior arc of the cricoid cartilage and stenosis of the subglottis and first and second tracheal rings. We used a composite hyoid–sternohyoid osseomuscular flap with xenogenic ADM and a straight silicone tube as a lumen stent to reconstruct the laryngotracheal stenosis.ResultsSurgical recovery was uneventful. The tracheotomy opening was changed to a metal tube 5 days postoperatively. Four months postoperatively, the silicone tube was endoscopically removed under local anesthesia. The patient was decannulated 20 days later. The patient satisfied with his voice, respiration, and deglutition at the 16-month postoperative follow-up.ConclusionThe use of ADM for laryngotracheal stenosis may reduce the growth of granulation tissues and promote the repair process.

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Comparing Myringoplasty to Type I Tympanoplasty in Tympanic Membrane Repair: A Systematic Review and Meta‐analysis

Jungbauer

Jeong

Nguyen

et al. 2023

Otolaryngol.--head neck surg.

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Objective To compare the anatomic success rates of type I tympanoplasty (tympanoplasty) versus myringoplasty. By our definition, tympanoplasty involves entering the middle ear via elevation of a tympanomeatal flap, while myringoplasty involves surgery to the drumhead without middle ear exposure. Data Sources PubMed, Scopus, CINAHL, Cochrane. Review Methods To be included, studies must have documented surgical technique, tympanic membrane (TM) perforation size (as % of TM), and success rate using tissue or alloplastic grafts. Exclusion criteria included series with more than 10% of patients with cholesteatoma or middle ear pathology. A meta‐analysis of weighted summary proportions under the random effects model was performed, and proportion differences (PD) were calculated. A secondary analysis of hearing outcomes was performed. Results Eighty‐five studies met inclusion, with a tympanoplasty cohort of n = 7966 and n = 1759 for myringoplasty. For perforations, less than 50% of the TM, the success rate for tympanoplasty and myringoplasty was 90.2% and 91.4%, respectively (PD: 1.2%, p = .19). In perforations greater than 50%, tympanoplasty and myringoplasty success rates were 82.8% and 85.3%, respectively (PD: 2.5%, p = .29). For both procedures, perforations less than 50% of the TM had higher success rates than perforations greater than 50% of the TM (p < .01). Both techniques endorsed significant improvements to air‐bone gap (ABG) metrics. Conclusion Our analysis suggests that the anatomic success rate is similar for tympanoplasty and myringoplasty, regardless of perforation size, and that smaller perforations experience higher success rates in both techniques. ABG outcomes were also similar between procedure techniques.

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Sutureless tympanoplasty using acellular dermis

Cited by 19 publications

References 11 publications

Collagen‐immobilized patch for repairing small tympanic membrane perforations: In vitro and in vivo assays

Collagen‐immobilized patch for repairing small tympanic membrane perforations: In vitro and in vivo assays

Traumatic laryngotracheal stenosis treated by hyoid–sternohyoid osseomuscular flap combined with xenogenic acellular dermal matrix: A case report and literature review

Comparing Myringoplasty to Type I Tympanoplasty in Tympanic Membrane Repair: A Systematic Review and Meta‐analysis

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