Sutures enriched with adipose-derived stem cells decrease the local acute inflammation after tracheal anastomosis in a murine model

Georgiev-Hristov, Tihomir; García-Arranz, Mariano; García-Gómez, Ignacio; García‐Cabezas, Miguel Ángel; Trébol, Jacobo; Vega-Clemente, Luz; Díaz-Agero, Prudencio; Garcı́a-Olmo, Damián

doi:10.1093/ejcts/ezs357

Cited by 32 publications

(34 citation statements)

References 25 publications

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“…Similar results have been reported by Wolbank et al 2009 [408], who also note that immortalization does not alter the immunosuppressive capacity of their ASCs. ASCs have been cultured with sutures to create "biosutures" capable of repressing inflammation in tracheal resections [409]. Finally, while decellularized dermal matrices have become quite popular in ASC-driven regeneration, the field is being expanded through studies seeding ASCs into other decellularized tissues, such as lung matrices [410] and tendons [411].…”

Section: Ascs For Somatic Cell Nuclear Transfer Immortalizedmentioning

confidence: 99%

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

2013

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In 2001, researchers at the University of California, Los Angeles, described the isolation of a new population of adult stem cells from liposuctioned adipose tissue. These stem cells, now known as adipose-derived stem cells or ADSCs, have gone on to become one of the most popular adult stem cells populations in the fields of stem cell research and regenerative medicine. As of today, thousands of research and clinical articles have been published using ASCs, describing their possible pluripotency in vitro, their uses in regenerative animal models, and their application to the clinic. This paper outlines the progress made in the ASC field since their initial description in 2001, describing their mesodermal, ectodermal, and endodermal potentials both in vitro and in vivo, their use in mediating inflammation and vascularization during tissue regeneration, and their potential for reprogramming into induced pluripotent cells.

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Section: Ascs For Somatic Cell Nuclear Transfer Immortalizedmentioning

confidence: 99%

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

2013

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“…Finally, lengths of sutures used to close a wound will get exposed to primary epidermal and dermal cells. It will be of note whether the inflammatory response is dampened (see Georgiev-Hristov T. et al, 2012) [19]. Another use for this technique could be in the healing of the donor site after a skin graft is obtained.…”

Section: Resultsmentioning

confidence: 99%

Tackling Post-Operative Cutaneous Scarring with Autologous Cell Therapy

Solomon¹

2017

OJRM

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Regenerative medicine has brought about refreshing new thinking about age old problems. However, some problems remain mostly untouched and are not being addressed. A point in question is the track of scar tissue left behind post-operatively, which reveals the surgeon's line of invasive incision. This confers on the patient an adverse psychological reminder and burden for the rest of his/her life. Most patients cannot afford corrective plastic surgery to ameliorate this skin defect. This paper seeks to ask whether biomedical scientists could play a role in arriving at a more pleasing cosmetic result, using a simple cell culture procedure of isolating un-manipulated autologous primary epidermal and dermal cells from a small skin tissue segment in close proximity to the surgeon's incision line.

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“…This outcome supports recent findings describing a modification of local immune response with absence of neutrophils in vivo . 42 …”

Section: Discussionmentioning

confidence: 99%

Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion

et al. 2014

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Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells (MSCs) have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40 (SV40) large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage.

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Sutures enriched with adipose-derived stem cells decrease the local acute inflammation after tracheal anastomosis in a murine model

Cited by 32 publications

References 25 publications

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

Adipose-Derived Stem Cells in Tissue Regeneration: A Review

Tackling Post-Operative Cutaneous Scarring with Autologous Cell Therapy

Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion

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