Swallowing Outcomes in Open Partial Horizontal Laryngectomy Type I and Endoscopic Supraglottic Laryngectomy: A Comparative Study

Saraniti, Carmelo; Ciodaro, Francesco; Galletti, C; Gallina, Salvatore; Verro, Barbara

doi:10.3390/ijerph19138050

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and the ability of antioxidants to neutralize them. Multiple forms of cancer, including laryngeal cancer, have been associated with its presence (49,50). Due to intermittent hypoxia and reoxygenation during sleep, obstructive sleep apnea syndrome (OSAS) has also been correlated with oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Incidence disparities of obstructive sleep apnea-associated lung cancer by gender; Korean National Health Insurance data analysis

2023

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IntroductionObstructive sleep apnea (OSA) is known to increase the risk of various cancers. By analyzing the Korea National Health Insurance Service (KNHIS) registry, the impact of OSA on the lung cancer incidence was analyzed in a retrospective cohort group.MethodsA retrospective cohort of adult patients newly registered with OSA in the KNHIS data from 2007 to 2017 was included and observed until December 2019 (12 years). The main outcome measure was newly diagnosed lung cancer. The control group was set with age and sex that matched those in the OSA group.ResultsThe hazard ratio (HR) of OSA for lung cancer incidence showed a significantly reduced HR of 0.87 (95% CI, 0.82–0.93). The observed significance of this finding was limited to male OSA patients [HR, 0.84 (95% CI, 0.78–0.90)], while no significant association was found in female OSA patients [HR, 1.05 (95% CI, 0.91–1.21)], irrespective of their age.DiscussionOSA patients have a lower risk of developing lung cancer, but this risk reduction is gender-specific, as female OSA patients do not show a reduction in hazard ratio.

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Section: Discussionmentioning

confidence: 99%

Incidence disparities of obstructive sleep apnea-associated lung cancer by gender; Korean National Health Insurance data analysis

2023

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“…In the short term, all patients with SCPL will have a certain degree of dietary choking cough that may lead to aspiration pneumonia and can be life-threatening in severe cases. However, different research institutions have reached different conclusions regarding whether patients who undergo SCPL have chronic aspiration more than half a year after surgery, whether the quality of life of these patients is affected by aspiration, and whether total laryngectomy is required in individuals with serious and persistent aspiration [ 6 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of swallowing and voice-related quality of life in patients after supracricoid partial laryngectomy

Liu,

Feng,

Liang

et al. 2024

Eur Arch Otorhinolaryngol

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Objective This study evaluated the swallowing and voice function of laryngeal cancer patients after Supracricoid Partial Laryngectomy(SCPL), and its influence on quality of life to provide a reference for the selection of surgical methods for laryngeal cancer patients. Methods Twenty-one patients who received SCPL between April 2015 and November 2021 were included. Each patient’s swallowing function and quality of life were assessed through fiberoptic endoscopic examination of swallowing (FEES) and the M.D. Anderson Dysphagia Inventory (MDADI). Fundamental, jitter, shimmer, maximum phonation time (MPT), and voice handicap index-10 (VHI-10) were performed to assess voice function and voice-related quality of life. Results The results of the FEES of the 21 patients were as follows: the rates of pharyngeal residue after swallowing solid, semiliquid, and liquid food were 0%, 28.57%, and 38.09%, respectively; the rates of laryngeal infiltration after swallowing solid, semiliquid, and liquid food were 0%, 28.57%, and 4.76%, respectively; and aspiration did not occur in any of the patients. In the evaluation of swallowing quality of life, the mean total MDADI score was 92.6 ± 6.32. The voice function evaluation showed that the mean F0, jitter, shimmer, and MPT values were 156.01 ± 120.87 (HZ), 11.57 ± 6.21 (%), 35.37 ± 14.16 (%) and 7.85 ± 6.08 (s), respectively. The mean total VHI-10 score was 7.14 ± 4.84. Conclusion SCPL provides patients with satisfactory swallowing and voice function. The patients in this study were satisfied with their quality of life in terms of swallowing and voice. SCPL can be used as a surgical method to preserve laryngeal function in patients with laryngeal cancer.

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Evaluation of different methods of transoral minimally invasive surgery for supraglottic laryngeal carcinoma

Wang,

Zhong,

Yang

et al. 2024

Cancer Reports

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Background and objectivesTo analyze oncological and functional results of transoral minimally invasive surgery (TMIS) for supraglottic laryngeal carcinoma (SGLC), and investigate independent prognostic factors.MethodsSeventy SGLC patients treated with TMIS were included. The overall survival (OS), recurrence‐free survival (RFS), and postoperative functions were analyzed.ResultsSixty‐two patients were early‐stage (Tis, T1, and T2) and eight patients were T3. Eleven patients received preoperative induction chemotherapy (IC). Sixty patients received transoral laser microsurgery (TLM), and 10 patients received transoral robotic surgery (TORS). Fifty‐eight patients were scored Grade‐1 by water swallow test, and 49 patients were scored Grade 0 by grade, roughness, breathiness, asthenia, strain. The 1, 3, and 5 year OS of all were 95.450%, 84.877%, and 78.026%, and RFS were 89.167%, 78.052%, and 75.451% respectively. Kaplan–Meier survival analysis showed N stage and clinical stage were associated with OS, smoking, clinical stage, surgical margins, and Ki‐67 index were associated with RFS. There were no significant differences in preoperative IC or direct surgery, TLM, or TORS. Cox analyses showed smoking and surgical margins were independent prognosis factors for RFS.ConclusionsThe positive margin, Ki‐67 index ≥40% and P53(+)&Ki‐67 index ≥40% are worse factors affecting recurrence for SGLC patients. Both smoking and surgical margins are independent prognostic factors affecting recurrence.

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Swallowing Outcomes in Open Partial Horizontal Laryngectomy Type I and Endoscopic Supraglottic Laryngectomy: A Comparative Study

Cited by 6 publications

References 25 publications

Incidence disparities of obstructive sleep apnea-associated lung cancer by gender; Korean National Health Insurance data analysis

Incidence disparities of obstructive sleep apnea-associated lung cancer by gender; Korean National Health Insurance data analysis

Analysis of swallowing and voice-related quality of life in patients after supracricoid partial laryngectomy

Evaluation of different methods of transoral minimally invasive surgery for supraglottic laryngeal carcinoma

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