Swarming towards the target

Wang, Yucai; Brown, Paige K.; Xia, Younan

doi:10.1038/nmat3060

Cited by 48 publications

(37 citation statements)

References 8 publications

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“…As an alternative choice, which is different from the bio-receptors mediated tumor targeting; physical manners for NPs tumor targeting have been developed. Extra-magnetic field (MF) mediated tumor targeting has been highlighted in the past decade 27-30. Magnetic NPs can be efficient targeted to the tumor site as well as the tumor microenvironment (which is also called stromal tumor component) 31.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer

Peng¹,

Qi²,

Liao³

et al. 2014

Theranostics

105

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Photothermal therapy (PTT) is proved to be an efficient manner for superficial tumor therapy in preclinical studying. The tumor suppression of chemotherapy can be enhanced by combining with PTT. In this study, we reported a mesoporous magnetic gold “nanoclusters” (MMGNCs) structure as theranostic carrier for chemo-photothermal co-therapy. MMGNCs were successfully prepared and they exhibited efficient photo-thermal effect for PTT. The mesoporous structure provided MMGNCs with high drug loading capacity. By in vitro cytotoxicity testing, we revealed that the combination of PTT and chemotherapy could cause more damage than chemotherapy or PTT did alone. By topically targeting mediated by the extra-magnetic field (MF), MMGNCs can be targeted to the tumor site efficiently. In vivo chemo-photothermal co-therapy of 4T1 breast cancer, under the combinational treatments of chemo-photothermal co-therapy and extra-MF targeting, the tumor growth has been efficiently inhibited, and the pulmonary and mediastinal metastasis have also been prevented. The survival of the cancer bearing mice was prolonged. The bio-imaging applications of this system and the mechanism of the metastasis prevention are ongoing.

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Section: Introductionmentioning

confidence: 99%

Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer

Peng¹,

Qi²,

Liao³

et al. 2014

Theranostics

105

View full text Add to dashboard Cite

show abstract

“…Nanoparticles can be composed of organic materials (e.g., lipids), inorganic materials (e.g., iron oxide or gold), or a combination of both types. Novel and improved nanostructured materials can be tailored by engineering (their) characteristics such as structure, stability, size, shape and surface properties in order for them to be selectively delivered to precise sites (target regions) of the body [58]. This can be achieved through passive or active targeting mechanisms: passive targeting is enabled by enhanced vascular permeability during neoangiogenesis of injured or pathological body sites, while active targeting benefits from overexpression in the infectious or damaged areas of several cell surface molecules that can bind specifically to precoated nanoparticle ligands [58,59].…”

Section: Nanomedicine: a Giant Leap Forward In Disease Diagnosis And Trmentioning

confidence: 99%

“…Novel and improved nanostructured materials can be tailored by engineering (their) characteristics such as structure, stability, size, shape and surface properties in order for them to be selectively delivered to precise sites (target regions) of the body [58]. This can be achieved through passive or active targeting mechanisms: passive targeting is enabled by enhanced vascular permeability during neoangiogenesis of injured or pathological body sites, while active targeting benefits from overexpression in the infectious or damaged areas of several cell surface molecules that can bind specifically to precoated nanoparticle ligands [58,59]. Recently, a dual modular system that mimics the communication-dependent recruitment of inflammatory cells to regions of disease has been developed to improve the tissue target efficiency of nanoparticles [60].…”

Section: Nanomedicine: a Giant Leap Forward In Disease Diagnosis And Trmentioning

confidence: 99%

Nanodentistry: Combining Nanostructured Materials and Stem Cells for Dental Tissue Regeneration

2012

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Regenerative dentistry represents an attractive multidisciplinary therapeutic approach that complements traditional restorative/surgery techniques and benefits from recent advances in stem cell biology, molecular biology, genomics and proteomics. Materials science is important in such advances to move regenerative dentistry from the laboratory to the clinic. The design of novel nanostructured materials, such as biomimetic matrices and scaffolds for controlling cell fate and differentiation, and nanoparticles for diagnostics, imaging and targeted treatment, is needed. The combination of nanotechnology, which allows the creation of sophisticated materials with exquisite fine structural detail, and stem cell biology turns out to be increasingly useful in regenerative medicine. The administration to patients of dynamic biological agents comprising stem cells, bioactive scaffolds and/or nanoparticles will certainly increase the regenerative impact of dental pathological tissues. This overview briefly describes some of the actual benefits and future possibilities of nanomaterials in the emerging field of stem cell-based regenerative dentistry.

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“…Nanocarriers with multifunctional components can interact with an external magnetic field positioned near a specified area that is targeted for drug delivery, and drug release can be triggered through the application of an external stimulus [2,3]. For example, some recently developed delivery systems have been triggered by means of ultrasound, light, pH changes, redox conditions, temperature and magnetic fields, thereby minimizing the systemic side effects (i.e., off-target effects) of the drugs [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Fe3O4@ZnS@Glycine nanoparticle as a novel microwave stimulus controlled drug release system

Peng

et al. 2016

J Sol-Gel Sci Technol

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The stimuli-responsive controlled drug delivery system is highly desirable for an efficient cancer treatment approach. Herein, we have successfully developed a novel multifunctional microwave stimulus controlled anticancer drug release system based on magnetic Fe 3 O 4 @-ZnS@Glycine nanoparticles. Fe 3 O 4 core has a high magnetization saturation value for drug targeting under foreign magnetic fields. ZnS shells can efficiently convert microwave energy into thermal energy for microwave-triggered drug release. The glycine-modified layer of nanoparticles provides active group (-NH 2 ) for the loading of drug molecules by hydrogen bond. The in vitro studies have clearly demonstrated the feasibility and advantage of the novel nanocarriers for remote-controlled drug release systems.Graphical Abstract We combined the advantages of ZnS nanoparticles with those of Fe 3 O 4 and glycine to create a new drug delivery system, which is capable of carrying drug molecules and triggered release of the drug by microwave treatment.

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Swarming towards the target

Cited by 48 publications

References 8 publications

Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer

Mesoporous Magnetic Gold “Nanoclusters” as Theranostic Carrier for Chemo-Photothermal Co-therapy of Breast Cancer

Nanodentistry: Combining Nanostructured Materials and Stem Cells for Dental Tissue Regeneration

Fe3O4@ZnS@Glycine nanoparticle as a novel microwave stimulus controlled drug release system

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