Swarms: The Next Frontier for Cancer Nanomedicine

Swana, Matimba; Blee, Johanna A; Stillman, Namid; Ives, Jonathan; Hauert, Sabine

doi:10.1007/978-3-031-04379-6_12

Cited by 2 publications

(2 citation statements)

References 87 publications

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“…In the context of particle manipulation, magnetic fields are used to trap, form and manipulate nanoparticle swarms for medical applications . For a thorough overview of the available platforms, we refer to a recent review . Rotating magnetic fields are commonly used to actuate different types of magnetic microrobots, including the ones locomoting in physiologically relevant flows as used here .…”

Section: Resultsmentioning

confidence: 99%

“…40 For a thorough overview of the available platforms, we refer to a recent review. 41 Rotating magnetic fields are commonly used to actuate different types of magnetic microrobots, including the ones locomoting in physiologically relevant flows as used here. 22 On the other hand, it would not be possible to actuate magnetic particles in the tubing center with such fields.…”

Section: Physical Characteristics Of Hollow Microparticlesmentioning

confidence: 99%

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Acoustic Trapping and Manipulation of Hollow Microparticles under Fluid Flow Using a Single-Lens Focused Ultrasound Transducer

Wrede,

Aghakhani,

Bozuyuk

et al. 2023

ACS Appl. Mater. Interfaces

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Microparticle manipulation and trapping play pivotal roles in biotechnology. To achieve effective manipulation within fluidic flow conditions and confined spaces, it is necessary to consider the physical properties of microparticles and the types of trapping forces applied. While acoustic waves have shown potential for manipulating microparticles, the existing setups involve complex actuation mechanisms and unstable microbubbles. Consequently, the need persists for an easily deployable acoustic actuation setup with stable microparticles. Here, we propose the use of hollow borosilicate microparticles possessing a rigid thin shell, which can be efficiently trapped and manipulated using a single-lens focused ultrasound (FUS) transducer under physiologically relevant flow conditions. These hollow microparticles offer stability and advantageous acoustic properties. They can be scaled up and mass-produced, making them suitable for systemic delivery. Our research demonstrates the successful trapping dynamics of FUS within circular tubings of varying diameters, validating the effectiveness of the method under realistic flow rates and ultrasound amplitudes. We also showcase the ability to remove hollow microparticles by steering the FUS transducer against the flow. Furthermore, we present potential biomedical applications, such as active cell tagging and navigation in bifurcated channels as well as ultrasound imaging in mouse cadaver liver tissue.

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Section: Resultsmentioning

confidence: 99%

Section: Physical Characteristics Of Hollow Microparticlesmentioning

confidence: 99%

Acoustic Trapping and Manipulation of Hollow Microparticles under Fluid Flow Using a Single-Lens Focused Ultrasound Transducer

Wrede,

Aghakhani,

Bozuyuk

et al. 2023

ACS Appl. Mater. Interfaces

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The occupational directness of nanorobots in medical surgeries

Atheena,

Rashika,

Krithina

et al. 2024

JME

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The incorporation of nanotechnology into the field of medicine is on the brink of bringing about a significant transformation in surgical procedures. Notable advancements in surgical nanorobots hold the promise of delivering improved levels of precision and functionality. In this comprehensive examination, we delve into recent progress and future trajectories in the domain of surgical nanorobots, with particular emphasis on advancements seen in biological and diamondoid-based nanorobots, computational nanomechatronics, and various techniques employed in nanomanufacturing. This discourse highlights key areas such as the evolutionary journey of nanorobots towards more intricate designs, the incorporation of intelligent materials into their structure, and the strides being made in the development of sophisticated targeting and navigation systems. Furthermore, the discussion extends to exploring the potential applications of nanorobots in minimally invasive surgeries and tele-operated procedures, emphasizing their crucial roles in tasks such as controlled drug release, actuation and mobility mechanisms, and the integration of cutting- edge sensing technologies. Novel approaches, including self-assembly processes, swarm robotics strategies, and the utilization of energy harvesting mechanisms, are thoroughly analyzed, highlighting their pivotal roles in enhancing the efficacy and autonomy of these miniature devices. Moreover, the narrative also addresses the various challenges that lie ahead and potential future pathways in materials engineering, targeting methodologies, diagnostic tools, and the seamless integration of nanorobots with the existing landscape of medical technologies. It is evident that, with the continuous stream of advancements being made, surgical nanorobots are poised to bring about a paradigm shift in patient care, ushering in unparalleled levels of precision and therapeutic capabilities.

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Swarms: The Next Frontier for Cancer Nanomedicine

Cited by 2 publications

References 87 publications

Acoustic Trapping and Manipulation of Hollow Microparticles under Fluid Flow Using a Single-Lens Focused Ultrasound Transducer

Acoustic Trapping and Manipulation of Hollow Microparticles under Fluid Flow Using a Single-Lens Focused Ultrasound Transducer

The occupational directness of nanorobots in medical surgeries

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