Sweat induction using Pilocarpine microneedle patches for sweat testing in healthy adults

Chen, Jonathan Yuxuan; Li, Song; Silva, George L.; Chandler, Joshua D.; Prausnitz, Mark R.; Guglani, Lokesh

doi:10.1016/j.jcf.2023.04.014

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…[ 45 ] Overall, the occurrence rate of pain is still less than that of erythema. [ 288 ] Another clinical study also reported the absence of any primary or cumulative skin reactions. [ 289 ] However, there are still some people who would prefer to use oral medications to address their condition rather than choose MNP.…”

Section: The Side Effects Of Mnpsmentioning

confidence: 99%

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Zhuang,

Wang,

Feng

et al. 2023

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Wounds and the subsequent formation of scars constitute a unified and complex phased process. Effective treatment is crucial; however, the diverse therapeutic approaches for different wounds and scars, as well as varying treatment needs at different stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), as a novel minimally invasive transdermal drug delivery system, has the potential for integrated and programmed treatment of various diseases and has shown promising applications in different types of wounds and scars. In this comprehensive review, the latest applications and biotechnological innovations of MNPs in these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, and manage related symptoms. Moreover, potential applications in various scenarios are discussed. Additionally, the side effects, manufacturing processes, and material selection to explore the clinical translational potential are investigated. This groundwork can provide a theoretical basis and serve as a catalyst for future innovations in the pursuit of favorable therapeutic options for skin tissue regeneration.

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Section: The Side Effects Of Mnpsmentioning

confidence: 99%

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Zhuang,

Wang,

Feng

et al. 2023

Small

View full text Add to dashboard Cite

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Remote endpoints for clinical trials in cystic fibrosis: Report from the U.S. CF foundation remote endpoints task force

Hoppe,

Sjoberg,

Hong

et al. 2024

Journal of Cystic Fibrosis

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Diagnosing cystic fibrosis in low- and middle-income countries: challenges and strategies

Fuhrer,

Zampoli,

Abriel

2024

Orphanet J Rare Dis

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Background Cystic Fibrosis is caused by recessively inherited variants of the cystic fibrosis transmembrane regulator. It is associated with diverse clinical presentations that can affect the respiratory, digestive, and reproductive systems and inhibit nutrient absorption and growth. Main Body The current estimation of people affected by Cystic Fibrosis is likely underestimated as this disease remains undiagnosed in countries with limited diagnostic capacity. Recent evidence indicates that Cystic Fibrosis is more common than initially thought and is likely underreported in low- and middle-income countries. The sweat chloride test remains the gold standard for diagnosing Cystic Fibrosis. However, the costs of commercially available instruments, consumables, and laboratory reagents remain relatively high for widespread implementation in low- and middle-income countries. Conclusion Alternative, cost-effective, and simpler approaches to sweat electrolyte measurement, may present more feasible options for CF diagnosis in the setting of low- and middle-income countries. Novel low-cost, point-of-care innovations for measuring sweat chloride should be explored and further validated as suitable alternatives. It will be important to consider how to implement these options and adjust the diagnostic algorithm to meet the needs of low- and middle-income countries. Future Cystic Fibrosis research in low- and middle-income countries should focus on finding a lower-cost and resource-intensive pathway for CF screening and diagnosis to improve its availability.

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Sweat induction using Pilocarpine microneedle patches for sweat testing in healthy adults

Cited by 3 publications

References 31 publications

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Remote endpoints for clinical trials in cystic fibrosis: Report from the U.S. CF foundation remote endpoints task force

Diagnosing cystic fibrosis in low- and middle-income countries: challenges and strategies

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