Sweet Block Copolymer Nanoparticles: Preparation and Self-Assembly of Fully Oligosaccharide-Based Amphiphile

Abstract

The preparation of biocompatible nanocarriers that have potential applications in the cosmetic and health industries is highly desired. The self-assembly of amphiphilic block copolymers displaying biosourced polysaccharides at the surface is one of the most promising approaches. In the continuity of our works related to the preparation of "hybrid" amphiphilic oligosaccharide-based block copolymers, we present here the design of a new generation of self-assembled nanoparticles composed entirely of oligosaccharide-based amphiphilic block co-oligomers (BCO). These systems are defined by a covalent linkage of the two saccharidic blocks through their reducing end units, resulting in a sweet "head-to-head" connection. As an example, we have prepared and studied a BCO in which the hydrophilic part is composed of a free maltoheptaosyl derivative clicked to a hydrophobic part composed of a peracetylated maltoheptaosyl derivative. This amphiphilic BCO self-assembles to form spherical micelles in water with an average diameter of 30 nm. The efficient enzymatic hydrolysis of the maltoheptaose that constitutes the shell of the micelles was followed by light scattering and colorimetric methods.

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2011–2012

“…Maltoheptose linked to peracetylated maltoheptaose -self assembles into nanoparticles (de Medeiros Modolon et al, 2012) Polymeric microspheres TOF (trans-3-(3-IAA)…”

A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery

“…The results show that the size ranges obtained by analyzing TEM photomicrographs are definitely smaller than those obtained by DLS experiment (Table 2). This can easily be explained by considering the physical state of analyzing the samples [6,52].…”

Polyglycerol-poly(ε-caprolactone) block copolymer as a new semi-solid polymeric emulsifier to stabilize O/W nanoemulsions

“…Therefore, various amphiphilic polymers have been studied and used as an emulsifier for industrial applications in the fields of food, cosmetics, drug delivery, etc. [13][14][15][16].…”