Sweet Cherry Extract Targets the Hallmarks of Cancer in Prostate Cells: Diminished Viability, Increased Apoptosis and Suppressed Glycolytic Metabolism

Silva, Gonçalo R.; Vaz, Cátia V.; Catalão, Beatriz; Ferreira, Susana; Cardoso, Henrique J.; Duarte, Ana Paula; Socorro, Sílvia

doi:10.1080/01635581.2019.1661502

Cited by 13 publications

(31 citation statements)

References 57 publications

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“…In vitro antioxidant assays, such as 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC) and nitric oxide (NO) assays, have demonstrated that sweet cherries display a high capacity to capture free radicals [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. Moreover, studies reported that sweet cherry extracts inhibit lipid peroxidation [ 44 , 45 ] and the oxidation of human low-density lipoprotein (LDL) [ 40 , 46 , 47 ] and liposomes [ 47 , 48 ]. Considering that lipids are highly susceptible to oxidation and a major cause for the increase of OS, these findings corroborate the antioxidant effect of sweet cherries.…”

Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

“…The majority of existent studies employed biochemical assays to demonstrate the antioxidant activity of sweet cherry extracts. However, in vitro studies with different cell cancer models also showed the biological potential of sweet cherry extracts in suppressing OS ( Table 2 , [ 38 , 40 , 42 , 45 , 49 , 52 , 56 ]). In human hepatocellular carcinoma HepG2 cells, sweet cherry extract reduced OS, with a differential response depending on the fruit variety and its amount of phenolic content [ 38 ].…”

Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

“…These effects were not observed when the pre-incubation time was 24 h, which indicates that the extract’s antioxidant action occurs through the direct scavenging of ROS, and not implicating the modulation of other endogenous mechanisms [ 42 ]. Also, in human prostate cancer LNCaP cells, sweet cherry extract had a protective effect against oxidative damage and lipid peroxidation [ 45 ]. However, the extract failed to influence the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) [ 45 ].…”

Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

“…Also, in human prostate cancer LNCaP cells, sweet cherry extract had a protective effect against oxidative damage and lipid peroxidation [ 45 ]. However, the extract failed to influence the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) [ 45 ]. Even considering the limitations discussed in Section 3 related to the bioavailability and bioaccessibility of bioactive compounds, in vivo evidence of the antioxidant capacity of sweet cherries remains compelling ( Table 2 ).…”

Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

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Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function

et al. 2021

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Sweet cherries (Prunus avium L.) are among the most appreciated fruits worldwide because of their organoleptic properties and nutritional value. The accurate phytochemical composition and nutritional value of sweet cherries depends on the climatic region, cultivar, and bioaccessibility and bioavailability of specific compounds. Nevertheless, sweet cherry extracts are highly enriched in several phenolic compounds with relevant bioactivity. Over the years, technological advances in chemical analysis and fields as varied as proteomics, genomics and bioinformatics, have allowed the detailed characterization of the sweet cherry bioactive phytonutrients and their biological function. In this context, the effect of sweet cherries on suppressing important events in the carcinogenic process, such as oxidative stress and inflammation, was widely documented. Interestingly, results from our research group and others have widened the action of sweet cherries to many hallmarks of cancer, namely metabolic reprogramming. The present review discusses the anticarcinogenic potential of sweet cherries by addressing their phytochemical composition, the bioaccessibility and bioavailability of specific bioactive compounds, and the existing knowledge concerning the effects against oxidative stress, chronic inflammation, deregulated cell proliferation and apoptosis, invasion and metastization, and metabolic alterations. Globally, this review highlights the prospective use of sweet cherries as a dietary supplement or in cancer treatment.

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Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

Section: Sweet Cherries and The Hallmarks Of Cancermentioning

confidence: 99%

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Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function

et al. 2021

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“…For example, the anticancer properties of sweet cherry extract were evaluated in LNCaP cells, revealing that cherry extract diminished the viability and oxidative damage to these cells, and suppressed glycolytic metabolism. 28 Wang and colleagues used LNCaP cells to investigate the apoptosis inhibitor baculoviral IAP repeat-containing protein3 (Birc3) and the role of its regulator eleven-nineteen-lysine-rich leukaemia protein (ELL2), which is a potential tumour-suppressor. Their findings suggest that Birc3 is an important player in ELL2 signalling and plays a role in driving prostate cancer proliferation.…”

Section: -D Cell Culture Modelsmentioning

confidence: 99%

An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research

et al. 2020

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Prostate cancer is one of the most commonly diagnosed cancers worldwide, particularly in elderly populations. To mitigate the expected increase in prostate cancer-related morbidity and mortality as a result of an expanding aged population, safer and more effective therapeutics are required. To this end, plenty of research is focusing on the mechanisms underlying cancer initiation and development, the metastatic process and on the discovery of new therapies. While animal models are used (mainly rats and mice) for the study of prostate cancer, alternative models and methods are increasingly being considered to replace, or at least reduce, the number of animals used in this particular field of research. In this review, we cover some of the alternative models that are currently available for use in the study of prostate cancer, including: mathematical models; 2-D and 3-D cell cultures; microfluidic devices; the chicken egg chorioallantoic membrane-based model; and zebrafish embryo-based models. The main advantages and limitations, as well as some examples of applications, are given for each type of model. According to our analysis, immortalised cell lines are still the most commonly used models in the field of prostate cancer research. However, the use of alternative models for prostate cancer research will likely become more prevalent in the coming years partly because of the increasing societal pressure to reduce the numbers of laboratory animals. In this context, the development and dissemination of effective non-animal alternative models assumes particular relevance and will be instrumental in leveraging their success. Taking these perspectives into account, we believe that technological advances will lead to more effective cell culture systems, namely 3-D cultures or organ-on-a-chip devices, which can be used to replace animal-based models in prostate cancer research.

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Novel insights in health-promoting properties of sweet cherries

Faienza

Corbo

Carocci

et al. 2020

Journal of Functional Foods

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Sweet cherry (Prunus avium L.) is one of the most popular and appreciated temperate fruit not only for its sensory and nutritional properties, but also for its content in bioactive compounds. Consumption of sweet cherries brings beneficial effects on to health, which include prevention and modulatory effects in several chronic diseases such as (diabetes mellitus, cancer, cardiovascular and other inflammatory diseases). The presence of natural polyphenolic compounds with high antioxidant potential might drive and partly explain such beneficial effects, but more translational and clinical studies should address this topic. Here, we review the health-promoting properties of cherries and their bioactive compounds against human diseases.

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Sweet Cherry Extract Targets the Hallmarks of Cancer in Prostate Cells: Diminished Viability, Increased Apoptosis and Suppressed Glycolytic Metabolism

Cited by 13 publications

References 57 publications

Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function

Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function

An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research

Novel insights in health-promoting properties of sweet cherries

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