Sweet's syndrome in infancy

Abstract

A 3-month-old Japanese girl developed tender erythematous elevated plaques on her face and buttocks with fever up to 38 degrees C. Histology showed a perivascular neutrophil infiltrate with nuclear debris in the dermis. Endothelial cells were swollen but no hyalinization of the vessel wall was observed. The lesions recurred several times and responded little to antibiotics but dramatically to oral corticosteroid. We diagnosed her skin condition as Sweet's syndrome in infancy.

Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome

“…[22][23][24] In the 'histiocytoid' histopathologic variant of Sweet syndrome, the immature myeloid cells that account for most of the infiltrate may be misinterpreted as histiocytes. 25 Sweet syndrome is very rare in neonates, 26 and a chronic course in children has only been associated with immunodeficiency. 27 A subset of Sweet syndrome is described in adult patients with myelodysplastic syndromes, 22,28-31 with recurrent edematous erythematous plaques over the face, trunk, and arms showing an annular configuration with sharply marked borders.…”

Acute febrile neutrophilic dermatosis (Sweet’s syndrome) in childhood and adolescence: two new patients and review of the literature on associated diseases

“…Twentyseven (42%) patients were categorized in the group "classic/idiopathic Sweet's syndrome". Thirteen (21%) of these presented without associated diseases (detailed data not shown [3,6,19,20,24,25,32,34,51,53,59]) and 14 patients (22%) were reported with transient diseases, mostly respiratory tract infections or otitis media [12,13,15,26,27,29,36,39,41,44,47,55]. These patients were not included in the detailed analysis and are not shown in Tables 2 and 3.…”

Cardiovascular Involvement in a Boy with Sweet's Syndrome

“…However, it is a rare disease in children, with only 25 published cases and with no clear sexual predominance at this age [5,7].…”