Sweet syndrome associated with ulcerative colitis

Malheiros, Anna Paula Rocha; Teixeira, Magaly Gêmio; Takahashi, Marcelo Straus; Almeida, Maristela Gomes de; Kiss, Desidério Roberto; Cecconello, Ivan

doi:10.1002/ibd.20227

Cited by 11 publications

(14 citation statements)

References 7 publications

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“…Benton et al [32] described its association with ulcerative colitis for the first time in 1985. Since then, a large number of case reports have confirmed this association [32,33,34,35,36,37,38,39,40,41,42,43,44,45,46]. The association of SS with Crohn's disease is less common, with fewer than 40 cases described in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, withdrawal of AZA and rechallenge with the drug indicated that at least in some of the above-mentioned cases [4,6,7,11,12,14], a direct association between AZA and SS existed. In another case, on the other hand, the AZA dose was increased and the rash eventually resolved [41]. As the systemic manifestations described for AZA hypersensitivity syndrome have all also been reported to occur with varying frequencies in SS, it is presumed that both denominations refer to variants of the same disease [49,50].…”

Section: Discussionmentioning

confidence: 99%

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Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature

Imhof¹,

Meier²,

Frei

et al. 2015

Dermatology

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Sweet's syndrome (SS) is a dermatosis with systemic symptoms characterized by tender, red nodules or papules, occasionally covered with vesicles, pustules or bullae, usually affecting the upper limbs, face and neck. SS is frequently observed in patients with leukemia or connective tissue diseases, while it is rather seldom in patients with inflammatory bowel disease. The exact pathogenesis of SS is only partially understood. We report the case of a 50-year-old patient with indeterminate colitis, presenting with a febrile diffuse papulopustular and necrotizing skin eruption that healed with significant scarring and appeared 14 days after onset of treatment with azathioprine. Histological examination revealed the presence of features typical of SS, gene expression analysis very high levels of interleukin-1β (IL-1β) mRNA in lesional skin, and immunohistochemistry high levels of IL-1β at the protein level. SS associated with azathioprine is being increasingly reported and is reviewed herein.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Severe Sweet's Syndrome with Elevated Cutaneous Interleukin-1β after Azathioprine Exposure: Case Report and Review of the Literature

Imhof¹,

Meier²,

Frei

et al. 2015

Dermatology

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“…Lastly, biologics, and primarily anti-TNF-α blocking agents, have been proposed. It is important to note that infliximab and etarnecept have been mainly proposed for patients with an associated disease such as inflammatory bowel disorder or inflammatory rheumatism [3,4,5,6,7,8,9,10]. The list of the local and systemic treatments available is summarized in table 2 [1,2].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Anti-Interleukin-1 Receptor Antagonist Anakinra (Kineret®) in a Case of Refractory Sweet’s Syndrome

et al. 2011

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Sweet’s syndrome is a neutrophilic dermatosis characterized by fever, an elevated neutrophil count, and painful erythematous cutaneous lesions. Histopathological analysis reveals a neutrophilic dermal infiltrate. Systemic corticosteroid therapy remains the mainstay of treatment. We report the case of a 66-year-old male patient who had a 5-year history of Sweet’s syndrome refractory to various conventional treatments. Anti-interleukin-1 receptor antagonist anakinra was initiated and this resulted in a dramatic clinical and biological improvement. Anakinra is a promising treatment for neutrophilic dermatoses and sheds light on the interleukin-1/inflammasome pathway as central in the physiopathology of neutrophilic dermatosis.

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“…[2][3][4] Sweet's syndrome and IBD is a rare association, with only 30 -40 cases in the literature. [5][6][7][8] This skin manifestation has been mostly described during active IBD, but may sometimes precede the onset of the disease. Colonic involvement is also constantly observed.…”

Section: To the Editormentioning

confidence: 99%