Sweet Syndrome

Dabbas, Disha

doi:10.5005/jp/books/13043_36

Cited by 1 publication

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“…Over the course of 22 years, the dermatology program at Boston Children’s Hospital treated seven patients with SS and found a higher frequency of appearance in females [ 4 ]. There is no increase in prevalence according to race [ 6 ]. Neutrophilic dermatosis consists of a large group of diseases in which skin lesions arise as a result of an immunologically mediated hypersensitivity phenomenon that cause loss of neutrophil infiltration regulation [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this reported clinical case, the patient met criteria for DS and SS. Infiltration of the subcutaneous cellular tissue is frequent and is characterized by the presence of nodules located on the anterior part of the legs [ 6 ]. The development of lobular panniculitis has been described as part of SS in patients with APL receiving ATRA [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

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Sweet Syndrome in an Adolescent Patient With Differentiation Syndrome Secondary to Promyelocytic Leukemia Treatment With All-Trans Retinoic Acid

et al. 2021

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Sweet syndrome (SS) is an acute febrile neutrophilic dermatosis that is histologically characterized by an infiltration of the dermis by neutrophils. A 12-year-old adolescent female patient recently diagnosed with acute promyelocytic leukemia presented with fever and was hospitalized for antibiotic management after 22 days of being treated with a treatment protocol based on daunorubicin, all-trans retinoic acid (ATRA), and prophylaxis with dexamethasone, the patient developed erythematous skin lesions located mostly on the extremities. Lesions evolved into painful subcutaneous nodules, and one lesion evolved into a 2.5-cm blister with a purple and necrotic base. A skin biopsy was performed and showed neutrophilic dermatosis which confirmed the diagnosis of SS. The patient's clinical features complied with criteria for differentiation syndrome complicated by shock. Two days after ATRA was suspended, the patient presented resolution of the fever and skin lesions. SS is a rare neutrophilic dermatosis secondary to an innate immune disorder classified into four categories: classical (idiopathic), para-inflammatory, paraneoplastic or pregnancy-related. SS has been described in patients with acute myeloid leukemia in adults secondary to the use of drugs such as ATRA or as a part of a paraneoplastic syndrome. SS can occur exceptionally in children with myeloid leukemia secondary to the use of drugs such as ATRA.

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