Swelling and drug release in hydrogel matrices: polymer viscosity and matrix porosity effects

Bettini, Ruggero; Colombo, Paolo; Massimo, Gina; Catellani, P. L.; Vitali, T

doi:10.1016/0928-0987(94)90025-6

Cited by 146 publications

(66 citation statements)

References 5 publications

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“…Increase in compression force should reduce the tablet porosity and, hence, decrease the drug release. Various researchers have studied the effect of compression force on drug release from various matrices (22)(23)(24) and reported a minimal effect of compression force on drug release. Liew et al (5) stated that the formation of a gel barrier around a matrix tablet controls the drug release behavior.…”

Section: Resultsmentioning

confidence: 99%

Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method

Mandal

Basu

2009

AAPS PharmSciTech

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Abstract. Alginate matrix tablet of diltiazem hydrochloride (DTZ), a water-soluble drug, was prepared using sodium alginate (SAL) and calcium gluconate (CG) by the conventional wet granulation method for sustained release of the drug. The effect of formulation variables like SAL/CG ratio, drug load, microenvironmental pH modulator, and processing variable like compression force on the extent of drug release was examined. The tablets prepared with 1:2 w/w ratio of SAL/CG produced the most sustained release of the drug extending up to 13.5 h. Above and below this ratio, the drug release was faster. The drug load and the hardness of the tablets produced minimal variation in drug release. The addition of alkaline or acidic microenvironmental modulators did not extend the release; instead, these excipients produced somewhat faster release of diltiazem. This study revealed that proper selection of SAL/CG ratio is important to produce alginate matrix tablet by wet granulation method for sustained release of DTZ.

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Section: Resultsmentioning

confidence: 99%

Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method

Mandal

Basu

2009

AAPS PharmSciTech

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“…Erosion and swelling fronts were measured in water by a technique previously reported by several authors (Bettini et al, 1994;Colombo et al, 1995Colombo et al, , 1996Colombo et al, , 1999Ferrero et al, 2000).…”

Section: Radial Front Movementmentioning

confidence: 99%

Swellable drug-polyelectrolyte matrices of drug-carboxymethylcellulose complexes. Characterization and delivery properties

2009

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“…The power law, otherwise known as the Korsmeyer-Peppas power law 45 , has been used in many pharmaceutical formulations [46][47][48][49] . The value of n is important in understanding the mechanism of release when it is unknown and often polymeric formulations can be categorised accordingly to this scale.…”

Section: Power Law: ∞ = •mentioning

confidence: 99%

Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine

Lungare

Bowen

Badhan

2016

Journal of Pharmaceutical Sciences

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The aim of this study was to develop and characterise an intranasal delivery system for amantadine (AMT). Optimal formulations (F) consisted of a thermosensitive polymer Pluronic ® 127 (P127) and either carboxy methyl cellulose (CMC) or chitosan (CS) which demonstrated gel-transition at nasal cavity temperatures (34 °C ± 1 °C). Rheologically, the loss tangent (Tan δ) confirmed a three-stage gelation phenomena at 34 °C ± 1 °C and nonNewtonian behaviour. Storage of FCMC and FCS at 4 °C for 8 weeks resulted in repeatable release profiles at 34 °C when sampled, with a Fickian mechanism earlier on but moving towards anomalous transport by week 8. Polymers (P127, CMC and CS) demonstrated no significant cellular toxicity to human nasal epithelial cells up to 4 mg/mL and up to 1 mM for AMT (IC50: 4.5 mM ± 0.05 mM). FCMC and FCS demonstrated slower release across an in-vitro human nasal airway model (43-44 % vs 79 % ± 4.58 % for AMT). Using a human nasal cast model, deposition into the olfactory regions (potential nose-to-brain) was demonstrated upon nozzle insertion (5 mm) whereas tilting of the head forward (15°) resulted in greater deposition in the bulk of the nasal cavity. KEYWORDSParkinson's disease; rheology; nasal; RPMI 2650; nose to brain; thermoresponsive; 3 INTRODUCTION Parkinson's disease (PD) is an ageing associated progressive neurological disorder and affects 1.5 % of the population over 65-years of age 1 , with age-adjusted prevalence rates thought to be around 150 per 100,000 with a suggested mean onset in the 70's 1 . Ageing is the largest single risk factor for the development of PD and the pathogenesis of PD is composed of a range of events leading towards neuronal apoptosis, primarily of degradation of dopamine neurones in the sustantia nigra. The mainstay of clinical drug therapy focuses on increases the levels of dopamine (DA) in the brain, with oral dosing of levodopa being the most commonly used to pharmacological intervention treatment to reverse the symptoms of PD. It is also common to use adjunct therapies in conjunction with levodopa, such as the weak NMDA-type receptor antagonist amantadine, which can aid in blocking dopamine reuptake.

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Swelling and drug release in hydrogel matrices: polymer viscosity and matrix porosity effects

Cited by 146 publications

References 5 publications

Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method

Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method

Swellable drug-polyelectrolyte matrices of drug-carboxymethylcellulose complexes. Characterization and delivery properties

Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine

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