Swept source optical coherence tomography angiography in optic disc melanocytoma

Jain, Astha; Thirumalesh, M B; Shetty, Bhujang

doi:10.1016/j.jcjo.2018.01.038

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…OCTA findings of ODMs has been described in few recent studies. 14,[25][26][27][28][29] In the present study, OCTA of optic nerve head revealed irregular thin vessels, heterogeneously distributed within the tumors, with some more prominent, as well as reported in literature. Blood vessel networks detected by OCTA could not be identified by FA, as expected, showing persistent hypofluorescence due to the deeply pigmentation of ODMs which blocks light penetration.…”

Section: Discussionsupporting

confidence: 86%

Multimodal imaging of optic disc melanocytoma

Mazzini

Vicini

Nicolosi

et al. 2021

European Journal of Ophthalmology

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Purpose: To describe the findings of four patients (four eyes) with optic disc melanocytoma (ODM), using multimodal imaging. Methods: Retrospective case series. Results: On ocular ultrasonography ODMs appeared as hyperechogenic lesions with moderate-to-high internal reflectivity. On blue-light fundus autofluorescence, ODMs showed total hypoautofluorescence, while, on infrared reflectance images appeared as bright and well-marginated lesions. MultiColor composite images showed reddish-brown lesions with well-defined margins. Swept-source optical coherence tomography revealed elevated lesions covering the optic disc with an irregular hyperreflective surface, dishomogeneous internal structure with hyperreflective dots, and posterior shadowing. In all cases optical coherence tomography angiography detected intratumoral blood vessels which were not detectable with fluorescein angiography. Conclusion: Multimodal imaging in ODM might be useful both at presentation, increasing the diagnostic accuracy, and at follow-up, providing helpful details, that can help to rule out the possibility of malignant transformation and other ocular complications.

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Section: Discussionsupporting

confidence: 86%

Multimodal imaging of optic disc melanocytoma

Mazzini

Vicini

Nicolosi

et al. 2021

European Journal of Ophthalmology

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“…Takkar et al reported the presence of superficial meshwork of vasculature over the ODM using SS-OCTA [21]. Jain et al reported OCTA findings including heterogeneously distributed sparse vasculature intrinsic to ODM with a prominent vessel seen in the center of the lesion [22]. OCTA is also useful in showing CNV, a finding associated with ODM in 1% of cases, especially if there is adjacent subretinal exudation, subretinal fluid, and subretinal hemorrhage.…”

Section: Optic Disc Melanocytomamentioning

confidence: 99%

Swept-source optical coherence tomography angiography findings in choroidal and retinal tumors

Gündüz

Mirzayev

Kasimoglu

et al. 2020

Eye

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Objectives To report the swept-source optical coherence tomography angiography (SS-OCTA) findings in choroidal and retinal tumors. Methods A retrospective noncomparative interventional case series of 60 eyes having various choroidal and retinal tumors imaged with SS-OCTA (Topcon DR1 Triton Plus, Tokyo, Japan) between September 2018 and February 2020 was conducted. Inclusion criteria were tumor thickness <4 mm, tumor base diameter <10 mm, and tumor location at the posterior pole. Results Choroidal nevi usually demonstrated well-defined borders, hyperreflective internal structure, and no outer retinal involvement on SS-OCTA. Choroidal melanoma, in contrast to nevi, usually had ill-defined borders (p = 0.018), mixed hyperreflective-hyporeflective or hyperreflective internal structure (p = 0.014), and demonstrated outer retinal involvement (p < 0.001). Circumscribed choroidal hemangioma usually presented with well-defined borders, a hyperreflective internal tumor structure with multiple dilated interconnected tumor vessels intermixed with signal void areas representing connective tissue. Optic disc melanocytomas showed a hyporeflective plexus related to blocking of signal by the pigment and an intact radial peripapillary capillary network. There was flow on the surface and slightly deeper within the lesion on B-scan angiography overlay. Retinal astrocytic hamartomas had well-defined borders and a hyperreflective vascular plexus in the superficial and deep retina. Outer retina and choriocapillaris showed hyporeflective change due to shadowing/masking from calcium or high blood flow in the lesion. Conclusions Each of the different retinal and choroidal tumors studied in this series presented with different SS-OCTA features to aid in the differential diagnosis of these conditions. Good quality images are obtained in patients with good fixation and tumors <3 mm in thickness located at the posterior pole.

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“…Obscuration of vessels may signify absence of vasculature or very densely packed cells, as well as posterior extent of the tumour. 14 Accordingly, we believe absence of BVN on OCTA is a useful indicator of impairment in tumour vascularity, which potentially resulted from ischaemic necrosis in the tumour or vascular compression by the tumour. 5 Decrease in perfusion from impaired vasculature may lead to RNFL thinning, ischaemic change in the optic nerve and eventually to visual field defect as was demonstrated in ODM as well as other disease related to the optic nerve.…”

Section: Discussionmentioning

confidence: 92%

“…9 29 Jain et al attributed attenuated signals on OCTA to vessel absence or very densely packed cells. 14 Correlation study between OCT features and pathology showed that ODMs can exert compression on the optic nerve and infiltrate into the optic nerve, the retina, as well as the choroid. 29 Our data suggest that BVN disturbance following tumour compression on optic nerve or infiltration to adjacent tissue is another important source of visual field defects.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of blood vessel network formation and visual field defect in optic disc melanocytoma

Kwak

Lee

et al. 2021

Br J Ophthalmol

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AimTo investigate the association between visual field defects and blood vessel network (BVN) formation in optic disc melanocytomas (ODMs) using optical coherence tomography angiography (OCTA).MethodsSingle-centre, retrospective case series of 32 eyes of 32 patients with ODM, in which eyes were divided into two groups based on complete and incomplete BVN formations.ResultsOCTA revealed incomplete BVN formation in 16 of 32 ODMs. The location of BVN absence corresponded to the location of hypofluorescence from fluorescein angiography (FA) in 12 (75%) and to the location of visual field defect in 13 (81%) ODMs in the incomplete BVN group. Perimetric indices were significantly worse in the incomplete BVN group than in the complete BVN group. Linear regression of mean deviation (MD) and Visual Field Index (VFI) on the area of BVN absence were statistically significant (p=0.01 and p=0.003, respectively), whereas linear regressions of MD and VFI on the tumour area were not statistically significant (both p=0.09) in the incomplete BVN group.ConclusionThe location of BVN absence within ODMs corresponded to the location of visual field defect and the location of FA hypofluorescence. Visual field defect was more severe in the incomplete BVN group than in the complete BVN group. Visual field defect was more significantly associated with the area of BVN absence than the tumour area.

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Swept source optical coherence tomography angiography in optic disc melanocytoma

Abstract: 12. Liu TY, Miller NR. Giant cell arteritis presenting as unilateral anterior ischemic optic neuropathy associated with bilateral optic nerve sheath enhancement on magnetic resonance imaging.

Cited by 6 publications

References 10 publications

Multimodal imaging of optic disc melanocytoma

Multimodal imaging of optic disc melanocytoma

Swept-source optical coherence tomography angiography findings in choroidal and retinal tumors

Evaluation of blood vessel network formation and visual field defect in optic disc melanocytoma

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