Swept-Source Optical Coherence Tomography Angiography Assessment of Fellow Eyes in Coats Disease

Stanga, Paulo E; Romanò, Francesco; Chwiejczak, Katarzyna; Tsamis, Emmanouil; Stringa, Francesco; Biswas, Susmito; Bento, Goncalo; Arrigo, Alessandro; Parodi, Maurizio Battaglia; Bandello, Francesco

doi:10.1097/iae.0000000000001995

Cited by 12 publications

(16 citation statements)

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“… 5 The study of macular changes in Coats disease determined by optical coherence tomography angiography (OCTA) has yielded inconclusive results concerning the laterality of Coats disease. 6 , 7 Schwartz et al 6 have shown significant differences in vascular density and foveal avascular zone (FAZ) when comparing affected and fellow eyes. Conversely, Stanga et al 7 have suggested that fellow eyes of Coats disease carry quantitative foveal vascular alterations compared with control eyes.…”

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confidence: 99%

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Evidence Against a Contralateral Coats Phenotype by Optical Coherence Tomography Angiography

Daruich

Zola

Elalouf

et al. 2022

Retina

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Purpose: To evaluate the laterality of Coats disease by analyzing optical coherence tomography angiography features in affected, fellow, and control eyes.Methods: Patients with Coats disease who underwent optical coherence tomography angiography were retrospectively reviewed. Healthy eyes of age-matched patients served as controls. Automated optical coherence tomography angiography determination of foveal avascular zone size and vascular density of superficial capillary plexus and deep capillary plexus was recorded.Results: Thirty-four patients with Coats disease (13 with bilateral optical coherence tomography angiography) and 24 controls were included. The foveal avascular zone was larger in affected eyes compared with fellow eyes (P = 0.004). Vascular density was decreased in affected eyes compared with fellow eyes in the superficial capillary plexus and deep capillary plexus whole images (P = 0.047 and P = 0.007) and in the deep capillary plexus at the fovea (P = 0.001). Vascular density was significantly reduced only in the deep capillary plexus in Stage 1 or 2A patients but in both plexuses in patients with Stage 2B1. No differences were shown on foveal avascular zone and vascular density values between fellow eyes of patients with Coats disease and controls. Conclusion:The foveal avascular zone is enlarged, and vascular density is decreased in affected eyes with Coats disease, but no differences are seen between fellow and control eyes, confirming the unilateral nature of the disease.

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confidence: 99%

“… 6 , 7 Schwartz et al 6 have shown significant differences in vascular density and foveal avascular zone (FAZ) when comparing affected and fellow eyes. Conversely, Stanga et al 7 have suggested that fellow eyes of Coats disease carry quantitative foveal vascular alterations compared with control eyes.…”

mentioning

confidence: 99%

Evidence Against a Contralateral Coats Phenotype by Optical Coherence Tomography Angiography

Daruich

Zola

Elalouf

et al. 2022

Retina

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“…; Stanga et al. ), which argues that the disease may affect both eyes, however, with a different susceptibility for or a delay between disease development in the two eyes. On the basis of this evidence, it might be hypothesized that the development of Coats’ disease could be related to impaired pressure autoregulation in retinal arterioles, which for some unknown reason leads to visible vasodilatation, hyperpermeability and exudation in one eye.…”

Section: Discussionmentioning

confidence: 99%

Retinal vasodilatation in the affected eye but reduced pressure autoregulation of both eyes in unilateral Coats’ disease

Petersen

Bek

2019

Acta Ophthalmologica

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Background Coats’ disease is characterized by vascular hyperpermeability, oedema and accumulation of exudates related to impairment of retinal vascular function. The background for the development of the disease is unknown, but it is likely that the study of diameter changes of retinal vessels may contribute to understanding the pathophysiology of the disease. Methods In seven patients with unilateral Coats’ disease (mean age = 34.7 years, range: 11–69 years), the baseline diameter and reactivity of retinal vessels during an increase in the arterial blood pressure by isometric exercise and in the metabolism by flicker stimulation were measured on video recordings of the retina obtained with the Dynamic Vessel Analyzer. Results The baseline diameter of retinal vessels was larger in the affected than in the unaffected eyes which was significant for the arterioles (p = 0.02), but not for the venules (p = 0.15). During an increase in the arterial blood pressure induced by isometric exercise, the normal contraction of arterioles was absent in both eyes (p > 0.7), whereas there was a significant dilatation of the venules in the unaffected eyes (p = 0.04). Stimulation with flickering light induced normal dilatation of retinal vessels in both affected and unaffected eyes. Conclusion Unilateral Coats’ disease is accompanied by vasodilatation in the affected eye but impaired pressure autoregulation in both eyes. A further investigation of the disease should include an elucidation of the background for dilatation of retinal vessels in affected eyes and whether impaired pressure autoregulation can be found in vessels elsewhere in the body.

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“…Finally, each image (the original unaltered image as well as versions with each of the above changes) was separately binarized using the following methods, which were identified as representing a near-comprehensive list of binarization algorithms (with the exception of custom methods that could not be reproduced) used in past OCTA studies: Global default 10 , 11 , global Huang 12 , global IsoData 13 , global mean 14 , 15 , global Otsu 16 , local Bernsen 17 , 18 , local mean 19 , local median 12 , 20 , local Niblack 21 – 23 , local Otsu 24 , and local Phansalkar 25 – 28 . All local thresholds were applied with a radius of 15 pixels based on the methods used in prior studies on the same devices we employed 25 – 28 .…”

Section: Methodsmentioning

confidence: 99%

Repeatability of binarization thresholding methods for optical coherence tomography angiography image quantification

Mehta

Braun

Gendelman

et al. 2020

Sci Rep

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Binarization is a critical step in analysis of retinal optical coherence tomography angiography (OCTA) images, but the repeatability of metrics produced from various binarization methods has not been fully assessed. This study set out to examine the repeatability of OCTA quantification metrics produced using different binarization thresholding methods, all of which have been applied in previous studies, across multiple devices and plexuses. Successive 3 × 3 mm foveal OCTA images of 13 healthy eyes were obtained on three different devices. For each image, contrast adjustments, 3 image processing techniques (linear registration, histogram normalization, and contrast-limited adaptive histogram equalization), and 11 binarization thresholding methods were independently applied. Vessel area density (VAD) and vessel length were calculated for retinal vascular images. Choriocapillaris (CC) images were quantified for VAD and flow deficit metrics. Repeatability, measured using the intra-class correlation coefficient, was inconsistent and generally not high (ICC < 0.8) across binarization thresholds, devices, and plexuses. In retinal vascular images, local thresholds tended to incorrectly binarize the foveal avascular zone as white (i.e., wrongly indicating flow). No image processing technique analyzed consistently resulted in highly repeatable metrics. Across contrast changes, retinal vascular images showed the lowest repeatability and CC images showed the highest.

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Swept-Source Optical Coherence Tomography Angiography Assessment of Fellow Eyes in Coats Disease

Abstract: Fellow eyes of Coats patients carry quantitative foveal vascular alterations at SCP. These may represent markers of altered inner blood-retinal barrier, due to a bilateral defect in midcapillary angiogenesis.

Cited by 12 publications

References 20 publications

Evidence Against a Contralateral Coats Phenotype by Optical Coherence Tomography Angiography

Evidence Against a Contralateral Coats Phenotype by Optical Coherence Tomography Angiography

Retinal vasodilatation in the affected eye but reduced pressure autoregulation of both eyes in unilateral Coats’ disease

Repeatability of binarization thresholding methods for optical coherence tomography angiography image quantification

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