Swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye

Grulkowski, Ireneusz; Manzanera, Silvestre; Cwiklinski, Lukasz; Sobczuk, Franciszek; Karnowski, Karol; Artal, Pablo

doi:10.1364/optica.5.000052

Cited by 51 publications

(36 citation statements)

References 37 publications

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“…Among all intraocular distances, the lowest ICC was found in corneal thickness, which was due to the axial resolution of the SS-OCT system and limited digital resolution of OCT images (size of the pixel in z-direction, 5 lm), which was also observed in other reports. 18,19,34 Another interesting observation showed that the time intervals Dt v and Dt acc had higher reproducibility than the times of velocity/acceleration extrema, which may be attributed to the signal processing procedure of identifying those markers in corneal apex velocity/acceleration waveform.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 Apart from visualization of all eye components, the concept of full-eyelength SS-OCT imaging at 1060 nm was demonstrated in ocular biometry, showing high repeatability and reproducibility and very good correlation with other biometers. 18,19 This has led to the introduction of a new generation of optical biometers, such as IOL Master 700 (Carl Zeiss Meditec, Inc., Dublin, CA, USA), Argos (Movu, Inc., Santa Clara, CA, USA), or OA-2000 (Tomey, Nagoya, Japan), enabling improved measuring of cataract patients. [20][21][22] Prototype spectral-domain-OCT and SS-OCT anterior segment instruments integrated with air-puff indentation were used to assess biomechanics of the cornea for different IOP levels and to assess biomechanic effects of cross-linking procedures.…”

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confidence: 99%

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Air-Puff-Induced Dynamics of Ocular Components Measured with Optical Biometry

Mączyńska

Rzeszewska-Zamiara

Jimenez-Villar

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To analyze the dynamics of all optical components of the eye and the behavior of the eyeball under air-puff conditions in vivo. To determine the impact of the intraocular pressure (IOP) on the air-puff-induced deformation of the eye. METHODS. Twenty eyes of 20 healthy subjects were included in this study. The dynamics of the ocular components, such as the cornea, the crystalline lens, and the retina, was measured by a prototype swept source optical coherence tomography biometer integrated with the air-puff system. The system allows to acquire a series of axial scans at the same location as a function of time with no transverse scanning. Several parameters were extracted from optical coherence tomography data. The IOP was measured using a Goldmann applanation tonometry. The measurements of the eyes were performed before and 2 hours after administration of IOP-reducing drops, namely, 0.2 % brimonidine tartrate. RESULTS. There is a statistically significant correlation of corneal thickness, vitreous depth, and eye length with IOP. The deformation amplitudes of the cornea and the crystalline lens are inversely proportional to the IOP, but statistical significance is achieved only for the cornea. The crystalline lens is displaced without compression, and the return has the form of wobbling. The reduction of IOP level induces corresponding changes in the extracted parameters. CONCLUSIONS. Optical biometry combined with air puff provides comprehensive information on the in vivo behavior of all ocular components, including the crystalline lens. Measurement of the axial length dynamics of during deformation enables correcting the deformation for eye retraction.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Air-Puff-Induced Dynamics of Ocular Components Measured with Optical Biometry

Mączyńska

Rzeszewska-Zamiara

Jimenez-Villar

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Fruto de esta actividad investigadora ha sido la generación de distintos tejidos artificiales como córnea (14) , piel (15,16), mucosa oral (17), nervio periférico (18), paladar (19), cartílago (20), etc. utilizando distintos tipos celulares, biomateriales , procesos de biofabricación (21,22,23) y protocolos de control de calidad de los que se ha dado cuenta en publicaciones científicas (24, 25,26,27,28,29,30).…”

Section: Reto Investigadorunclassified

“…Se producen por liberación de sustancias constrictoras endógenas, pero también por uso de sustancias ilícitas vasospásticas, como cocaína o anfetaminas (25). Hasta un 46% de los pacientes con MINOCA responden a test de provocación de espasmo con ergonovina y acetilcolina (Ach).…”

Section: Figura 7 Mecanismo Del Desarrollo De Una Placa Arteriosclerunclassified

“…A modo de ejemplo, una de las últimas aportaciones, pendiente de incorporación a clínica, se ha efectuado incluyendo una lente de enfoque sintonizable (cambia la posición del foco en función de una señal eléctrica) lo que facilita la obtención imágenes 3D in vivo versátiles tanto del segmento anterior del ojo como de la retina. Gracias al control dinámico del foco del haz óptico se obtienen visualización de los detalles vítreos, por ejemplo, en la unión vítreo-lenticular y vítreo-retiniana con una calidad y definición sin precedentes [25].…”

Section: Tomografía De Coherencia óPtica (Oct)unclassified

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2019

an. ranm

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in the United States and Canada are very complex since include, along with Anatomic Pathology, the laboratory services of the medical center (8). The traditional divisions are: 1) Anatomic Pathology, 2) Clinical Pathology (Laboratory Medicine) and more recently, 3) Genomics and 4) Community or Regional Pathology. Anatomic Pathology is subdivided in: 1) Surgical Pathology Subspecialty Services (i.e. Neuro, GI, Breast, Cardiac, Bone, Uropathology, etc.), 2) Cytology and 3) Autopsy. Clinical Pathology or Laboratory is subdivided in: 1) Chemistry, 2) Hematopathology, 3) Microbiology, 4) Human Leukocyte Antigen (HLA) / Transplant, 5) Molecular Pathology, 6) Transfusion Medicine, 7) Coagulation. Genomics is subdivided in: 1) Cytogenetics and 2) Molecular Genetics Departments of Genetics have a Clinical Division, frequently subdivided into: 1) Prenatal, 2) General Genetics, 3) Inborn Errors of Metabolism and 4) Cancer Genetics. As above mentioned, Institutes are structured based on COEs. This concept is easy to understand in disea-DIAGNOSTIC INSTITUTE DEPARTMENTS OF RADIOLOGY, PATHOLOGY AND GENETICS IN THE UNITED STATES

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Green Manufacturing of Electrically-Tunable Smart Light-Weight Planar Optics: A Review

Yang,

Lee,

Kang

et al. 2024

Int. J. of Precis. Eng. and Manuf.-Green Tech.

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Evolving demands for compact, light-weight, and versatile optical systems across various industries require the facile integration of planar diffractive optics. For the manufacturing of diffractive optics, green manufacturing becomes the prerequisite with timely considerations of Environmental, Social, and Governance (ESG). Conventional manufacturing processes such as semiconductor lithography or nano /micro imprinting utilize a large amount of harmful chemicals. Meanwhile, direct laser writing emerges as one of the key solution candidates, offering clear advantages over others, especially in terms of eco-friendliness due to the simple manufacturing process with less chemical usage. In this comprehensive review, we present recent advances in the analytical design, green manufacturing of electrically tunable smart light-weight planar optics, and their promising applications in space optics, photovoltaics, and optical imaging, highlighting the necessity for tunability in focal length, aberration, transparency, and beam propagation direction. Various types of electrically tunable diffractive optical elements utilizing active modulation of refractive index, geometrical shape, and bandgap have been discussed. Finally, this review concludes by proposing the integration of ultra-thin and light-weight diffractive optics presenting potential applications in micro-electronics, biomedical imaging, space exploration, and extended reality.

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Swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye

Cited by 51 publications

References 37 publications

Air-Puff-Induced Dynamics of Ocular Components Measured with Optical Biometry

Air-Puff-Induced Dynamics of Ocular Components Measured with Optical Biometry

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Green Manufacturing of Electrically-Tunable Smart Light-Weight Planar Optics: A Review

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