Switchable Antimicrobial and Antifouling Hydrogels with Enhanced Mechanical Properties

Cao, Bin; Tang, Qiong; Li, Linlin; Humble, Jayson; Wu, Haiyan; Liu, Lingyun; Cheng, Gang

doi:10.1002/adhm.201200359

Cited by 143 publications

(132 citation statements)

References 31 publications

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“…[101] poly (56) The reversible switch was reported on the surface of poly (45) with a structure based on 2-morpholinone [98,102] prepared by SI ATRP. The structure contained a quaternary amine lactone Poly (53) H + (polymer brushes, hydrogel) [100] Poly (54) 14 opened under neutral or basic conditions. An increasing number of bonds in the lactone made the ring formation difficult, hence stronger conditions were necessary to form the ring.…”

Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

“…Interestingly, the incorporation of hydroxyl groups in the monomer of poly(53) accelerated the ring formation. In TFA, the monomer of poly(53) switched up to 99% in 15 minutes and in 0.2 M HAc, the monomer of poly(53) was able to reach an 84% conversion within 20 h [100]. These results indicate that the monomer of poly (53) is more favorable for ring formation than the monomer of poly(51) due to the symmetrical substitution giving rise to opportunities to cyclize on both sides, resulting in faster ring formation.…”

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confidence: 99%

“…These results indicate that the monomer of poly (53) is more favorable for ring formation than the monomer of poly(51) due to the symmetrical substitution giving rise to opportunities to cyclize on both sides, resulting in faster ring formation. The ring-opening kinetics was investigated in alkaline condition [100]. Only the poly(47) hydrogel exhibited good switchability and ring stability and thus was able to kill and subsequently release almost 99.5% of the dead E. coli cells from the surface [99].…”

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confidence: 99%

“…The best results were obtained with poly(47) followed by poly (49). Since the carboxybetaine zwitterionic hydrogel with 6-membered lactone rings, poly(51), suffers from insufficient mechanical properties, the hydroxyl groups were incorporated into the monomer unit of poly(53) [100]. The introduction of hydroxyl groups resulted in the formation of hydrogen bonds between the polymer chains.…”

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confidence: 99%

“…Poly(53) adsorbed proteins at a density of 0.8 ng/cm 2 and poly(51) at a density lower than the limit of detection of 0.3 ng/cm 2 ; in the 100% human blood plasma poly(51) modified the surface-adsorbed proteins at a density of 0.2 ng/cm 2 and poly(30) at a density of 2.4 ng/cm 2 . Since all the values of fibrinogen adsorption were below 5 ng/cm 2 , the material can be expected to delay the blood coagulation caused by platelets activation [100].…”

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confidence: 99%

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Switchable Materials Containing Polyzwitterion Moieties

2015

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Abstract:In recent decades, the design and construction of smart materials capable of switching into a polyzwitterionic state by an external trigger have been intensively pursued. Polyzwitterionic states have unique antifouling and surface properties and external triggers, such as pH, light, ions, electric field and CO 2 , cause significant changes in materials with regard to overall charge, ionic strength and wettability. This survey highlights current progress in the irreversible as well as the reversible switching process involving polyzwitterionic moieties, which can, in turn, be applied to studying the interaction of various interfaces with biological species as protein, DNA, bacteria or platelets and also for advanced use.

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Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Switchable Materials Containing Polyzwitterion Moieties

2015

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Anti‐Biofouling and Healable Materials: Preparation, Mechanisms, and Biomedical Applications

Liu

Guo

2018

Adv Funct Materials

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Preventing biofouling is challenging for a wide range of biomedical applications. Although materials with good anti-biofouling properties are reported, their antifouling functions are readily lost when detachments or scratches occur through physical damage and chemical degradation by water, oxygen, or possible catalytic ions in water containing reactive environments. Consequently, it is important to develop durable anti-biofouling materials with healing abilities. This review summarizes the important developments in five kinds of antibiofouling materials categorized according to healing mechanisms and material properties in the recent five years, namely structural rearrangement-, reaction-, ionic bond-, and hydrogel-based healing materials, as well as other healable antifouling materials. The healing mechanisms and potential biomedical applications of these healable anti-biofouling materials are emphasized.We focus on the "functional" self-healing, i.e., the recovery of anti-biofouling properties. Five types of anti-biofouling and healable materials are discussed in detail based on the healing mechanisms and material properties. Potentials of these antifouling mechanisms in various biomedical applications and some future perspectives are proposed. Anti-Biofouling and Healable MaterialsThe general requirements of designing antifouling and healable materials are introduced in detail in this section based on healing mechanisms and the materials used. Three types of anti-biofouling and healable materials, namely, structural rearrangement-, reaction-, and ionic bond-based antifouling healable materials were classified based on the healing mechanisms. Additionally, hydrogel-based antifouling self-healing materials were listed as a specific class of materials. Each item was discussed and summarized in Table 1 with several recent examples reported by various research groups. In addition, some other antifouling healable materials were also introduced briefly.Generally, the healing process is characterized by morphology-based methods such as rheology, tensile tests, and cut-/scratch-healing tests with the assistance of scanning electron microscopy (SEM), optical microscope images, and atomic force microscopy (AFM), which also quantify the healing efficiency. Infrared (IR) spectroscopy or linear Raman spectra can monitor the formation or cleavage of chemical bonds and supramolecular interactions in the healing process. Recently, Popp and co-workers proposed that coherent anti-Stokes Raman scattering, a nonlinear Raman variant can be used as molecular characterization of healing process. It acquires morphological and molecular information simultaneously and thus offers a different observation from conventional morphological-based methods. [12] The anti-biofouling properties are usually evaluated by wettability measurements as well as the resistance ability to proteins, cells, bacteria, algas, and other microorganisms. In the wettability measurements, contact angle (CA) and contact angle hysteresis (CAH) experiments are used ...

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Polysaccharide–Peptide Conjugates: A Versatile Material Platform for Biomedical Applications

Song

Fan

et al. 2020

Adv Funct Materials

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Natural polymers, such as polysaccharides and proteins, have been widely studied for numerous biomedical applications because of their bioactivity, natural origin, and biodegradability. To address the different needs of a broad spectrum of biomedical applications, natural polymers are modified with or conjugated to small molecular compounds, synthetic and natural polymers, and inorganic nanomaterials and surfaces. Among these hybrid materials, polysaccharide–peptide conjugates have drawn much attention due to their design flexibility, biocompatibility, tunable degradability, and structure similarity to naturally occurring glycoproteins. In the past 20 years, polysaccharide–peptide conjugates have demonstrated the promising potential to address many long‐standing medical challenges. Thus, the design, conjugation chemistry and method, and biomedical applications of polysaccharide–peptide conjugates are summarized and discussed in this review. The conjugation techniques are reviewed from the view of the chemical reactions. Meanwhile, some inspiring examples of polysaccharide–peptide conjugates in biomedical applications, including drug delivery systems, nucleic acid delivery carriers, tissue engineering, and antimicrobial applications, are highlighted. Moreover, the outlook on the challenges and demands of polysaccharide–peptide conjugates is also elaborated.

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Switchable Antimicrobial and Antifouling Hydrogels with Enhanced Mechanical Properties

Cited by 143 publications

References 31 publications

Switchable Materials Containing Polyzwitterion Moieties

Switchable Materials Containing Polyzwitterion Moieties

Anti‐Biofouling and Healable Materials: Preparation, Mechanisms, and Biomedical Applications

Polysaccharide–Peptide Conjugates: A Versatile Material Platform for Biomedical Applications

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