Switching from systemic steroids to ciclesonide restores the hypothalamic pituitary-adrenal axis

Marczak, Jerzy; Ciebiada, Maciej; Górski, Paweł

doi:10.5114/pdia.2014.40924

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…The safety of ICS, especially when using high doses, depends on their dose, formulation and pharmacological properties. Marczak published a study in which he showed that switching from prednisone to very high doses of ciclesonide normalized the hypothalamic-pituitary adrenal axis function and also improved the disease control and the lung function in patients with difficult asthma [21].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of ciclesonide in the treatment of patients with asthma exacerbation

Ziętkowski

Łukaszyk

Skiepko

et al. 2019

pdia

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Introduction Progressing deterioration of the lung function, dyspnoea, cough, wheezing and chest tightness are the main features of asthma exacerbations. The first step in the prevention of severe asthma exacerbations is to intensify the anti-inflammatory treatment with high doses of inhaled corticosteroids (ICS). Aim To assess the efficacy of ciclesonide in patients who have been losing control of asthma despite being treated with medium doses of inhaled corticosteroids and long-acting β 2 -agonists (LABA) as the second controller. Material and methods The study was conducted in a group of 74 asthmatic patients who have been losing control of their asthma. Subjects entering the study received the following anti-inflammatory interventions: high doses of ciclesonide (1280 μg) or 640 μg of ciclesonide added to a current dose of ICS or a doubled dose of current ICS. Results Treatment options containing ciclesonide have shown statistically and clinically important advantages (improvement of Asthma Control Test score, reduction in rescue medication consumption, reduction in day and night symptoms score, improvement in spirometry parameters, decrease in exhaled nitric oxide, and no necessity of oral corticosteroids treatment) in comparison to patients for whom medium doses of the previously used inhaled corticosteroid were doubled. Conclusions Treating with high doses of ciclesonide is characterised by a quick and potent anti-inflammatory effect as well as prompt clinical improvement along with the proper safety profile in patients experiencing asthma exacerbations.

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Section: Discussionmentioning

confidence: 99%

Efficacy of ciclesonide in the treatment of patients with asthma exacerbation

Ziętkowski

Łukaszyk

Skiepko

et al. 2019

pdia

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Control of moderate-to-severe asthma with randomized ciclesonide doses of 160, 320 and 640 μg/day

Pedersen¹,

Prasad²,

Goehring³

et al. 2017

JAA

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BackgroundThe inhaled corticoteroid (ICS) ciclesonide (Cic), controls asthma symptoms in the majority of patients at the recommended dose of 160 µg/day. However, the relationship between the level of asthma control and increasing doses of Cic is unknown. This study investigated whether long-term treatment with higher doses of Cic would further improve asthma symptoms in patients with uncontrolled asthma despite ICS use.Patients and methodsIn a double-blind, randomized, parallel-group study, 367 patients were allocated to one of three treatment arms (Cic 160, 320 and 640 µg/day). After a single-blind, 3-week baseline period with Cic 160 µg/day, eligible patients were randomized to receive 52 weeks of treatment with Cic 160, 320 or 640 µg/day (double-blind period) during which forced expiratory volume in 1 second (FEV1), exacerbations and Asthma Control Questionnaire (ACQ) scores were measured.ResultsTreatment with all the three doses was associated with significant improvements in ACQ scores, FEV1 and asthma symptoms (P<0.01). There were no statistically significant differences between the three doses. The results of the primary end point analysis showed a numerical improvement in the ACQ score with Cic 640 µg/day compared with Cic 160 µg/day (least square [LS] mean: −0.122; two-sided P-value: 0.30). Post hoc subgroup analyses showed that the improvement in the ACQ score with Cic 640 µg/day compared with Cic 160 µg/day was statistically significant in subjects who experience at least one exacerbation per year (LS mean: −0.586; 95% confidence interval: −1.110, −0.062, P=0.0285). Adverse events were low and consistent with the known safety profile of Cic.ConclusionIn patients with persistent, uncontrolled asthma, increasing the Cic dose from 160 to 640 µg/day provided no clear additional effect. Patients who experience more than one exacerbation per year may benefit from higher doses; however, further studies are necessary to confirm this. All Cic doses were well tolerated.

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Switching from systemic steroids to ciclesonide restores the hypothalamic pituitary-adrenal axis

Cited by 2 publications

References 32 publications

Efficacy of ciclesonide in the treatment of patients with asthma exacerbation

Efficacy of ciclesonide in the treatment of patients with asthma exacerbation

Control of moderate-to-severe asthma with randomized ciclesonide doses of 160, 320 and 640 μg/day

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Switching from systemic steroids to ciclesonide restores the hypothalamic pituitary-adrenal axis

Cited by 2 publications

References 32 publications

Efficacy of ciclesonide in the treatment of patients with asthma exacerbation

Efficacy of ciclesonide in the treatment of patients with asthma exacerbation

Control of moderate-to-severe asthma with randomized ciclesonide doses of 160, 320 and 640 &mu;g/day

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Control of moderate-to-severe asthma with randomized ciclesonide doses of 160, 320 and 640 μg/day