Switching to Aggressive Statin Improves Vascular Endothelial Function in Patients with Stable Coronary Artery Disease

Hoshiga, Masaaki; Arishiro, Kumiko; Nakakoji, Takahiro; Miyazaki, Norihiko; Negoro, Nobuyuki; Okabe, Tetsuro; Kohbayashi, Eiko; Ishihara, Tadashi; Hanafusa, Toshiaki

doi:10.5551/jat.3848

Cited by 13 publications

(9 citation statements)

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“…Increases in CD and TBARS levels in serum of venous and arterial blood of patients with CAD suggested increased production of lipid peroxidation. The results obtained for TBARS levels are consistent with recently published observations which showed increased TBARS levels in patients with CAD [29][30][31]. However, Halevy et al [32] found no change in TBARS levels of CAD patients.…”

Section: Discussionsupporting

confidence: 82%

Paraoxonase-1 activity and the levels of lipids and lipid peroxidation markers in arterial versus venous blood samples in coronary angiography patients

Göçmen¹,

Gümüşlü²,

Günaydın³

et al. 2012

pwki

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A b s t r a c tIntroduction: The percutaneous catheterization of various arteries is used in visualization of coronary arteries. Aim: We aimed to determine whether arterial blood samples withdrawn from femoral arteries during standard Judkin's technique in patients evaluated with coronary angiography can also be used to determine some biochemical parameters.Material and methods: In 50 controls (25 males and 25 females) and 73 coronary artery disease (CAD) patients (10 females and 63 males) paraoxonase-1 (PON1) activity, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels were measured using colorimetric methods. Lipid peroxidation marker levels (conjugated dienes (CD) and thiobarbituric acid-reactive substances (TBARS)) were measured manually.Results: There was no difference in lipid and lipid peroxidation marker levels, PON1 activity and TC/HDL-C, LDL-C/HDL-C and PON1/HDL-C ratios between arterial and venous blood samples. LDL-C, CD and TBARS levels and TC/HDL-C and LDL-C/HDL-C ratios were significantly lower in both arterial and venous blood samples of controls compared with CAD patients. Paraoxonase-1 activity, HDL-C level and PON1/HDL-C ratio were higher in controls than CAD patients. On multiple logistic regression analysis, risk factors associated with CAD were found to be the levels of arterial CD, venous CD, arterial TBARS and arterial LDL-C/HDL-C ratios in CAD patients.Conclusions: Our study might indicate that arterial blood samples can also be used as well as venous samples to determine these parameters. On the other hand, elevated arterial lipid peroxides are associated with cardiovascular complications, presumably by decreasing PON1 activity.Key words: paraoxonase, artery, vein, lipids, lipid peroxidation, coronary artery disease S t r e s z c z e n i e Wstęp: Cewnikowanie przezskórne jest wykorzystywane w obrazowaniu tętnic wieńcowych. Cel: Określenie, czy próbki krwi tętniczej pobrane z tętnicy udowej u pacjentów poddawanych koronarografii standardową techniką Judkinsa mogą zostać użyte do oceny niektórych parametrów biochemicznych.Materiał i metody: Przy użyciu metod kalorymetrycznych u 50 osób z grupy kontrolnej (25 mężczyzn i 25 kobiet) oraz u 73 pacjentów (10 kobiet i 63 mężczyzn) z chorobą wieńcową oceniono aktywność paraoksonazy 1 (PON1), stężenie cholesterolu całkowitego (total cholesterol -TC), cholesterolu lipoprotein o niskiej gęstości (low-density lipoprotein cholesterol -LDL-C), cholesterolu lipoprotein o bardzo niskiej gęstości (very low-density lipoprotein cholesterol -VLDL-C), cholesterolu lipoprotein o wysokiej gęstości (highdensity lipoproteid cholesterol -HDL-C) oraz triglicerydów (triglycerides -TG). Poziomy markerów peroksydacji lipidów [sprzężone dieny (conjugated dienes -CD) oraz związki reagujące z kwasem tiobarbiturowym (thiobarbituric acid-reactives substances -TBARS)] określono ręcznie.

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Section: Discussionsupporting

confidence: 82%

Paraoxonase-1 activity and the levels of lipids and lipid peroxidation markers in arterial versus venous blood samples in coronary angiography patients

Göçmen¹,

Gümüşlü²,

Günaydın³

et al. 2012

pwki

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“…The majority of patients were on statin therapy (75%) at baseline, and had lower levels of sCD40L compared to those that were not. Statin use has been shown to significantly decrease sCD40L levels in patients with coronary artery disease (CAD) 40, 41 . Although aspirin has been shown to suppress sCD40L levels in patients with chronic heart failure 42 , we did not see an effect of aspirin use in the current cohort.…”

Section: Discussionmentioning

confidence: 99%

Effect of CD40 and sCD40L on Renal Function and Survival in Patients With Renal Artery Stenosis

et al. 2013

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Activation of the CD40 receptor on the proximal tubular epithelium of the kidney results in fibrosis and inflammation in experimental models of kidney injury. Soluble CD40 ligand is released by activated platelets. The role of CD40-soluble CD40 ligand in patients with ischemic renal disease is unknown. Plasma levels of CD40 and soluble CD40 ligand were measured by enzyme linked immunosorbent assay in a single center cohort of 60 patients with renal artery stenosis recruited from Salford Royal Hospital, Manchester, UK. A natural log transformation of CD40 and soluble CD40 ligand was performed to normalize the data. Estimated glomerular filtration rate was used as the primary indicator of renal function. By univariate analysis low baseline levels of circulating CD40 (R2=0.06, p<0.05) and baseline creatinine (R2=0.08, p=0.022) were associated with loss of kidney function at one-year follow-up, whereas soluble CD40 ligand was not (R2=0.02, p=ns). In a multiple linear regression model CD40 (p<0.02) and baseline creatinine (p<0.01) continued to be significantly associated with a decline in renal function (model R2=0.17, p<0.005). Baseline CD40 levels were somewhat lower in patients who died during follow-up (survivors, 7.3 ± 0.9 pg/ml, n=48 vs. non-survivors, 6.7 ± 1.0 pg/ml, n=12, p=0.06). The CD40/soluble CD40 ligand signaling cascade may be a novel mechanism contributing to the development and progression of renal injury in patients with atherosclerotic renal artery stenosis.

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“…Han ve arkadajlannm PD hastalannda yaptigi çalijmada valsartan tedavisine eklenen statinin sadece ARB tedavisine göre endotel fonksiyonlanni daha iyi korudugu gözlenmijtir (24). ileri dönük yapilan bir çalijmada stabil koroner arter hastaligi olanlarda agresif statin tedavisine geçen hastalarda endotel fonksiyonlarmí n daha iyi korundugu bulunmu §tur (25). Bajka bir çalijmada ise atorvastatinin tip 2 DM'lu hastalarda endotel fonksiyonlannda iyiiejme yaptigi saptanmijtir (26).…”

Section: Tartiçmaunclassified

Periton Diyalizi Hastalarında Yeni Bir Endotel Fonksiyonu Belirteci: Apelin

Karadağ¹,

Gürsu²,

Öztürk³

et al. 2013

Haseki

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Özet. AbstractAmaç: Son dönem böbrek yetersizliginde en önemli mortalité sebebi kardiyovasküler hastaliklardir (KVH). KVH patogenezinde en önemli basamaklardan birisi endotel disfonksiyonudur (ED). Apelin son yillarda kardiyovasküler sistem ve endotel fizyolojisinde önemli rolleri gösterilmij bir peptiddir. Çalijmamizda periton diyalizi (PD) hastalannda apelin ile endotel fonksiyonlan arasindaki ilijkiyi incelemeyi planladik.Yöntem: Haseki Egitim ve Arajtirma Hastanesi PD Ünitesi'nden takipli 42 hasta çalijmaya alindi. Endotel fonksiyonlan ultrasonografik olarak akim aracili dilatasyon (AAD) yüzdesi ile degerlendirildi. Hastalarda aliñan kan örneklerinde rutin biyokimyasal tetkikler ve apelin ölcümü yapildi. Bulgular: Apelin ile AAD yüzdesi arasmda négatif korelasyon saptandi (r=-0.334, p=0.03). AAD yüzdesi ile trigliserid ve çok düjük dansiteli Iipoprotein (VLDL) düzeyleri arasmda pozitif korelasyon oldugu görüldü (sirasiyla r=0.310, p=0.046; r=0.304, p=0.05). AAD yüzdesi ile sistolik kan basmci ve diyastolik kan basinci arasinda anlamli négatif korelasyon mevcuttu (sirasiyla r=0.565, p=<0.001; r=0.560, p=<0.001). Hipertansiyon olan grupta olmayan gruba göre AAD yüzdesi belirgin olarak düjük bulundu (sirasiyla 9.0±5.8 ve 14.9+6.6; p=0.01).Sonuç: ED PD hastalannda hipertansiyon ve lipid profili ile yakm ilijkilidir Apelin ise PD hastalarinda ED agsmdan yeni bir belirteç ve tedavi alternatifi olarak kullanilabilir. (Haseki Tip Bùlteni2013; 51:5-10) Anahtar Kelimeler: Apelin, endotel disfonksiyonu, periton diyalizi Aim: The most important cause of death in end-stage renal disease is cardiovascular diseases (CVDs). Endothelial dysfunction (ED) is one of the most important steps in the pathogenesis of CVD Apelin is a peptide recently found to have important roles in cardiovascular and endothelial physiology; and we planned in our study to examine the relationship between apelin and endothelial functions in peritoneal dialysis (PD) patients. Methods:Forty-two patients who were followed up in the PD unit at Haseki Training and Research Hospital were involved. Endothelial functions were evaluated ultrasonographically by flow-mediated dilation (FMD) test. Apelin levels and routine laboratory tests were studied from the blood samples obtained from the patients. Results: There was a negative correlation between apelin and FMD percentage (r=-0.334, p=0.03). FMD percentage positively correlated with triglycéride and very low density Iipoprotein levels (r=0.310, p=0.046; r=0.304, p=0.05, respectively). FMD percentage significantly positively correlated with systolic and diastolic blood pressure (r=0.565,p=<0.001; r=0.560,p=<0.001, respectively). FMD was significantly lower patients with hypertension, compared to those without hypertension (9±5.8 vs. 14.9±6.6; p=0.01). Conclusion: ED is closely related with hypertension and lipid profile in PD patients. Apelin may be used as a new marker for ED and a treatment alternative in PD patients. (The Medical Bulletin of Haseki 2013; 51: 5-10)

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Switching to Aggressive Statin Improves Vascular Endothelial Function in Patients with Stable Coronary Artery Disease

Cited by 13 publications

References 40 publications

Paraoxonase-1 activity and the levels of lipids and lipid peroxidation markers in arterial versus venous blood samples in coronary angiography patients

Paraoxonase-1 activity and the levels of lipids and lipid peroxidation markers in arterial versus venous blood samples in coronary angiography patients

Effect of CD40 and sCD40L on Renal Function and Survival in Patients With Renal Artery Stenosis

Periton Diyalizi Hastalarında Yeni Bir Endotel Fonksiyonu Belirteci: Apelin

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