Sympathetic neuron derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes
Yitao Zhu,
Lu Yao,
Ana Luisa Gallo-Ferraz
et al.
Abstract:Neuropeptide Y (NPY) is secreted by sympathetic nerves1,2, but its direct impact on thermogenic adipocytes is unknown. Here we uncover the mechanism by which peripheral NPY protects from obesity. Our imaging of cleared murine brown and white adipose tissue (BAT and WAT) established that NPY+ sympathetic axons are only a minority that mostly maps to the peri-vasculature; our analysis of single-cell RNA-sequencing datasets identifies mural cells as the main NPY-responsive cells in adipose tissues. We show that N… Show more
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