Sympathoadrenergic Regulation

Weicker, H

doi:10.1055/s-2008-1025797

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…The neuronal and adrenomedullary release of NE and EPI respectively, might additionally be supported by deconjugation of sulfoconjugated CA, which is expressed by the decreasing concentrations of sulfoconjugated CA and their ratio to free CA. These findings are in accordance with earlier studies in which the load-induced changes of free and sulfoconjugated plasma CA levels were explored (5,13,23,24). On the other hand, lowest NE levels were found at the end of the resting periods after recreation with PMR with Cl.…”

Section: Discussionsupporting

confidence: 92%

“…The percentage of catecholamine sulfates of the total amount decreased after the first and the second run without significant differences between the three recreation treatments. Blood sampling perometric detection (HPLCA), a method described previously (22)(23)(24). Venous serum lactate concentrations were determined enzymatically (18).…”

Section: Participants and Methodsmentioning

confidence: 99%

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Influence of Different Experimental Recreation Treatments on Sympathoadrenergic and Metabolic Regulation Mechanisms in Repeated Exercises

Litschka-Schimpf¹,

Manzl²,

Schimpf³

et al. 1988

Int J Sports Med

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Section: Discussionsupporting

confidence: 92%

Section: Participants and Methodsmentioning

confidence: 99%

Influence of Different Experimental Recreation Treatments on Sympathoadrenergic and Metabolic Regulation Mechanisms in Repeated Exercises

Litschka-Schimpf¹,

Manzl²,

Schimpf³

et al. 1988

Int J Sports Med

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“…Although Jost et al (1989) could not ®nd any dierences in the lymphocyte b-adrenoceptor density and responsiveness between weight-lifters and untrained men, an acutely increased adrenergic sensitivity following E1 can not be totally excluded. It is known that the number of catecholamine receptors on the cell surfaces of thrombocytes, monocytes and lymphocytes increases very rapidly after a short-term maximal exercise bout (Weicker 1986). Jost et al (1990) have also reported that lymphocyte b-adrenoceptor density and responsiveness increase after high-intensity training, and that this increase is positively correlated with an increased basal NA:A ratio.…”

Section: Discussionmentioning

confidence: 99%

Plasma catecholamine responses and neural adaptation during short-term resistance training

Pullinen¹,

Huttunen

Komi³

2000

European Journal of Applied Physiology

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Low exercise-induced plasma adrenaline (A) responses have been reported in resistance-trained individuals. In the study reported here, we investigated the interaction between strength gain and neural adaptation of the muscles, and the plasma A response in eight healthy men during a short-term resistance-training period. The subjects performed 5 resistance exercises (E1-E5), consisting of 6 sets of 12 bilateral leg extensions performed at a 50% load, and with 2 days rest in between. Average electromyographic (EMG) signal amplitude was recorded before and after the exercises, from the knee extensor muscles in isometric maximal voluntary contraction (MVC) as well as during the exercises (aEMGmax and aEMGexerc, respectively). Total oxygen consumed during the exercises (VO2tot) was also measured. All of the exercises were exhaustive and caused significant decreases in MVC (34-36%, P < 0.001). As expected, the concentric one-repetition maximum (1-RM), MVC and aEMGmax were all higher before the last exercise (E5) than before the first exercise (E1; 7, 9 and 19%, respectively, P < 0.05). In addition, in E5 the aEMGexerc:load and VO2tot:load ratios were lower than in E1 (-5 and -14%, P < 0.05), indicating enhanced efficiency of the muscle contractions, However, the post-exercise plasma noradrenaline (NA) and A were not different in these two exercises [mean (SD) 10.2 (3.8) nmol x l(-1) vs 11.3 (6.0) nmol x l(-1), ns, and 1.2 (1.0) nmol x l(-1) vs 1.9 (1.1) nmol x l(-1), ns, respectively]. However, although NA increased similarly in every exercise (P < 0.01), the increase in A reached the level of statistical significance only in E1 (P < 0.05). The post-exercise A was also already lower in E2 [0.7 (0.7) nmol x l(-1), P < 0.05) than in E1, despite the higher post-exercise blood lactate concentration than in the other exercises [9.4 (1.1) mmol x l(-1), P < 0.05]. Thus, the results suggest that the observed attenuation in the A response can not be explained by reduced exercise-induced strain due to the strength gain and neural adaptation of the muscles. Correlation analysis actually revealed that those individuals who had the highest strength gain during the training period even tended to have an increased post-exercise A concentration in the last exercise as compared to first one (r = 0.76, P < 0.05).

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“…We have also demonstrated an association between GABA levels in left basal ganglia and plasma MHPG levels. There is an accumulating body of evidence showing a role of noradrenaline in brain development, neuronal differentiation (Lauder et al, 1986;Weicker, 1986;Ren et al, 2003), and working memory (Eckhoff et al, 2009;Radley et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Associations between plasma levels of 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) and negative symptoms or cognitive impairments in early‐stage schizophrenia

Gotō

Yoshimura

Kakeda

et al. 2009

Human Psychopharmacology

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Schizophrenic patients demonstrate a variety of cognitive deficits, including attention, executive functions, and working memory, even in the early stage of disease. In the present study, we examined the association between blood levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), or brain-derived neurotrophic factor (BDNF) and scores on the Wisconsin Card Sorting Test (WCST) in patients with early-stage schizophrenia. We also investigated the association between frontal GABA levels using 1H-magnetic resonance spectroscopy (MRS) at 3T and scores on the WCST in the same patients. Blood levels of BDNF and catecholamine metabolites and brain GABA levels using 1H-MRS were measured in 18 schizophrenic patients (nine males, nine females; age range 13-52 year). A significantly positive correlation was observed between plasma MHPG levels and %PEM (rho = -0.686, p = 0.0047). A trend toward negative correlation was found between frontal lobe GABA levels and the per cent of preservation error (%PEM) in the early stage of schizophrenia (rho = -0.420, p = 0.0836). These results suggest that noradrenergic neurons might be involved in neuropsychological functions in early-stage of schizophrenia.

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Sympathoadrenergic Regulation

Cited by 11 publications

References 16 publications

Influence of Different Experimental Recreation Treatments on Sympathoadrenergic and Metabolic Regulation Mechanisms in Repeated Exercises

Influence of Different Experimental Recreation Treatments on Sympathoadrenergic and Metabolic Regulation Mechanisms in Repeated Exercises

Plasma catecholamine responses and neural adaptation during short-term resistance training

Associations between plasma levels of 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) and negative symptoms or cognitive impairments in early‐stage schizophrenia

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