Symptom Clusters, Functional Status, and Quality of Life in Older Adults With Osteoarthritis

Jenkins, Jeanne B.; McCoy, Thomas P.

doi:10.1097/nor.0000000000000112

Cited by 20 publications

(19 citation statements)

References 37 publications

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“…Pain subsequent to knee OA also impacts well‐being through incremental fatigue (Hodges et al, ), distress, and depressive symptoms, again affecting quality of life (Sugai et al, ). The symptom cluster of pain, fatigue, and depressive symptoms is related to functional status and quality of life among older people with knee OA (Jenkins & McCoy, ). Although the breadth of investigations has expanded greatly, an association between knee OA symptoms and quality of life remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Path model of factors influencing health‐related quality of life among older people with knee osteoarthritis

Aree‐Ue

Kongsombun

Roopsawang

et al. 2019

Nursing & Health Sciences

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Chronic illness has a significant effect on quality of life, and a critical measure of health outcomes. Correlations between pain, depressive symptoms, fatigue, and physical function and their direct and indirect effects on quality of life were determined among 200 Thai older population with knee osteoarthritis using the Numeric Rating Scale, the Multidimensional Assessment of Fatigue, and the Thai Geriatric Depression Scale‐15. Physical function was investigated by using the Timed Up and Go test. Path analysis revealed significant negative direct paths from pain, depressive symptoms, fatigue, and Timed Up and Go test results to quality of life. Pain, fatigue, and the Timed Up and Go test results had indirect effects on quality of life, while depressive symptoms had no indirect effect on quality of life. Increases in pain, depressive symptoms, fatigue, and Timed Up and Go test results were associated with reductions in quality of life. An understanding of the complex relationship among these variables is beneficial for designing an appropriate intervention for improving quality of life among older people with knee osteoarthritis.

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Section: Introductionmentioning

confidence: 99%

Path model of factors influencing health‐related quality of life among older people with knee osteoarthritis

Aree‐Ue

Kongsombun

Roopsawang

et al. 2019

Nursing & Health Sciences

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“…Studies that tried to identify specific phenotype may have oversampled high-risk patients, thus leading to elevated prevalence rates. A similar bias was the inclusion of only patients listed for joint replacement [24,26,28]. Furthermore, the evidence presented in this review is limited by the research focus of published studies and their quality.…”

Section: Discussionmentioning

confidence: 99%

“…Among the 25 studies included, four had a strong risk of bias [25,28,30]. The main source of bias was the presence of confounding factors; of all the studies included in the review, only four studies presented a low risk of bias in that specific area [7,8,27,40].…”

Section: Discussionmentioning

confidence: 99%

185 Identification of Clinical Phenotypes in Knee Osteoarthritis: A Systematic Review of the Literature

et al. 2016

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Background: Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms of the disease. Methods: The aim of this study is to identify the current evidence for the existence of groups of variables which point towards the existence of distinct clinical phenotypes in the KOA population. A systematic literature search in PubMed was conducted. Only original articles were selected if they aimed to identify phenotypes of patients aged 18 years or older with KOA. The methodological quality of the studies was independently assessed by two reviewers and qualitative synthesis of the evidence was performed. Strong evidence for existence of specific phenotypes was considered present if the phenotype was supported by at least two high-quality studies.

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“…Fatigue severity and interference were included as potential predictors in the analysis because fatigue and pain occurred together in a symptom cluster in knee and hip osteoarthritis [2, 31]. These two symptoms may share similar underlying pain mechanisms and may also affect the severity of postoperative pain [32].…”

Section: Methodsmentioning

confidence: 99%

“…Living with OA is associated with chronic pain, disability, fatigue, depressed mood, and decreased quality of life [2, 3]. More than 50% of adults diagnosed with knee OA undergo total knee arthroplasty (TKA) [4] in order to relieve pain and improve function.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Pain, Symptoms, and Psychological Factors related to Higher Acute Pain Trajectories during Hospitalization for Total Knee Arthroplasty

et al. 2016

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ObjectivesUnrelieved postoperative pain after total knee arthroplasty (TKA) is a significant problem. This longitudinal study investigated how preoperative pain intensity, as well as a comprehensive list of preoperative and perioperative factors, influenced the severity of acute average and worst pain after TKA.MethodsPrior to surgery, 203 patients completed a demographic questionnaire, Lee Fatigue Scale, Fatigue Severity Scale, Hospital Anxiety and Depression Scale, and Brief Illness Perception Questionnaire. Brief Pain Inventory was completed prior to surgery as well as through postoperative days (POD) 0 to 4. Clinical data were extracted from medical records.ResultsSeveral factors were associated with higher levels of preoperative and postoperative pain. Lower preoperative average and worst pain intensity scores were associated with increases in average and worst postoperative pain from POD1 to POD4. A higher number of comorbidities, higher C-reactive protein values, and higher pain interference with function were associated with higher preoperative levels of average pain. Older age, higher fatigue levels, and higher scores on identity and emotional responses to osteoarthritis (OA) were associated with higher preoperative levels of worst pain. Lower perceived consequences of OA were associated with higher pain from POD1 to POD4. Males and patients with lower preoperative scores for average pain had higher worst pain following surgery.DiscussionPatients at higher risk for more severe postoperative pain can be identified through an assessment of pain and other risk factors identified in this study. Future research needs to test the efficacy of interventions that modify patients’ perceptions of living with OA and pain intensity before surgery on short and long term postoperative outcomes.

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Symptom Clusters, Functional Status, and Quality of Life in Older Adults With Osteoarthritis

Abstract: The findings of this study provide a foundation for targeted interventions to improve QOL and functional status of older adults with OA of the knee.

Cited by 20 publications

References 37 publications

Path model of factors influencing health‐related quality of life among older people with knee osteoarthritis

Path model of factors influencing health‐related quality of life among older people with knee osteoarthritis

185 Identification of Clinical Phenotypes in Knee Osteoarthritis: A Systematic Review of the Literature

Preoperative Pain, Symptoms, and Psychological Factors related to Higher Acute Pain Trajectories during Hospitalization for Total Knee Arthroplasty

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