Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire

Zanten, Sander Veldhuyzen van; Armstrong, David; Barkun, Alan N.; Junghard, Ola; White, Robert J.

doi:10.1111/j.1365-2036.2007.03271.x

Cited by 30 publications

(18 citation statements)

References 42 publications

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“…Subsequently, a further validation paper appeared [3,8] and RDQ has now been shown to be reliable, valid and responsive to change in patients with GERD symptomatology and those with dyspepsia, making this tool suitable for use in clinical trials and as a guide to patient management also in a broader primary care population with uninvestigated upper GI symptoms [8]. As a matter of fact, RDQ has been used in large randomized controlled trials, such as, for example, the ProGERD study [9].…”

Section: Discussionmentioning

confidence: 98%

Validation of the reflux disease questionnaire for an Italian population of patients with gastroesophageal reflux disease

Pace

Scarlata

Casini

et al. 2008

European Journal of Gastroenterology & Hepatology

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Section: Discussionmentioning

confidence: 98%

Validation of the reflux disease questionnaire for an Italian population of patients with gastroesophageal reflux disease

Pace

Scarlata

Casini

et al. 2008

European Journal of Gastroenterology & Hepatology

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“…The RDQ has recently been documented as a diagnostic tool for GERD in patients consulting with upper gastrointestinal symptoms in primary care [12] and as a means of monitoring treatment response [13,14]. …”

Section: Methodsmentioning

confidence: 99%

Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC) epidemiological study

Wang

Zou

et al. 2010

Health Qual Life Outcomes

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BackgroundGastroesophageal reflux disease imposes a significant burden of illness in Western populations. However, data on the impact of reflux symptoms on daily life in Asian populations are scarce. The current study aimed to evaluate the impact of GERD (defined on the basis of symptoms) on health-related quality-of-life (HRQoL) in individuals from five regions in China, as part of the Systematic Investigation of Gastrointestinal Diseases in China (SILC) study.MethodsIn total, 18 000 residents were randomly selected from across five regions of China and asked to complete a general information questionnaire and a Chinese version of the Reflux Disease Questionnaire (RDQ). A randomly selected subsample of one-fifth of subjects (20% from each region) completed Chinese versions of the 36-item self-administered (SF-36) questionnaire and Epworth Sleepiness Scale (ESS) questionnaire. Reflux symptoms were defined as the presence of heartburn and/or regurgitation. Symptom-defined GERD was diagnosed as mild heartburn and/or regurgitation ≥2 days per week, or moderate/severe heartburn and/or regurgitation ≥1 day a week, based on the Montreal Definition of GERD for population-based studies.ResultsThe response rate was 89.4% for the total sample (16 091/18 000), and for the 20% subsample (3219/3600). Meaningful impairment was observed in all 8 SF-36 dimensions in participants with symptom-defined GERD, in 7 of the 8 SF-36 dimensions in participants with troublesome reflux symptoms, and in 6 of the 8 SF-36 dimensions in participants with reflux symptoms below the threshold for symptom-defined GERD. Meaningful daytime sleepiness was also observed in each of these groups. The proportion of individuals reporting troublesome symptoms increased as reflux symptom frequency and severity approached the threshold for symptom-defined GERD, and this was associated with concomitant decreases in all HRQoL measures. Troublesome symptoms were reported by 68.2% (75/110) of individuals with symptom-defined GERD.ConclusionsGERD diagnosed using symptom/frequency criteria (recommended for population-based studies), or based on troublesome reflux symptoms (recommended for the clinic), is associated with significantly impaired HRQoL in Chinese individuals. However, patient groups identified using these definitions do not overlap completely, suggesting that they capture slightly different, though clinically relevant, GERD populations.

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“…Each questionnaire had a high Cronbach's alpha coefficient (≥ 0.8), suggesting good reliability. The internal consistency of the RDQ dimensions replicated findings from the original RDQ, as well as other language versions [48,71]. Although test-retest reliability, known-groups validity and responsiveness to change were not assessed, the test-retest reliability of the Chinese versions of the RDQ and SF-36 was previously established in the Shanghai pilot study [27].…”

Section: Discussionmentioning

confidence: 56%

“…A GERD dimension can be obtained by combining the heartburn and regurgitation dimensions, and the epigastric pain dimension is also known as the dyspepsia dimension. There is strong evidence supporting the validity and reliability of the RDQ as a diagnostic tool in primary care [47] and as a measure of treatment response in clinical trials [48,49]. Previous investigators found that a Chinese version of the RDQ tested in 10 hospitals in China was able to identify the presence of reflux symptoms experienced during the previous month [50].…”

Section: Methodsmentioning

confidence: 99%

Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology

et al. 2009

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BackgroundSymptom-based surveys suggest that the prevalence of gastrointestinal diseases is lower in China than in Western countries. The aim of this study was to validate a methodology for the epidemiological investigation of gastrointestinal symptoms and endoscopic findings in China.MethodsA randomized, stratified, multi-stage sampling methodology was used to select 18 000 adults aged 18-80 years from Shanghai, Beijing, Xi'an, Wuhan and Guangzhou. Participants from Shanghai were invited to provide blood samples and undergo upper gastrointestinal endoscopy. All participants completed Chinese versions of the Reflux Disease Questionnaire (RDQ) and the modified Rome II questionnaire; 20% were also invited to complete the 36-item Short Form Health Survey (SF-36) and Epworth Sleepiness Scale (ESS). The psychometric properties of the questionnaires were evaluated statistically.ResultsThe study was completed by 16 091 individuals (response rate: 89.4%), with 3219 (89.4% of those invited) completing the SF-36 and ESS. All 3153 participants in Shanghai provided blood samples and 1030 (32.7%) underwent endoscopy. Cronbach's alpha coefficients were 0.89, 0.89, 0.80 and 0.91, respectively, for the RDQ, modified Rome II questionnaire, ESS and SF-36, supporting internal consistency. Factor analysis supported construct validity of all questionnaire dimensions except SF-36 psychosocial dimensions.ConclusionThis population-based study has great potential to characterize the relationship between gastrointestinal symptoms and endoscopic findings in China.

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Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire

Abstract: SUMMARY BackgroundThe reflux disease questionnaire (RDQ) is a short, patient-completed instrument.

Cited by 30 publications

References 42 publications

Validation of the reflux disease questionnaire for an Italian population of patients with gastroesophageal reflux disease

Validation of the reflux disease questionnaire for an Italian population of patients with gastroesophageal reflux disease

Impact of gastroesophageal reflux disease on daily life: the Systematic Investigation of Gastrointestinal Diseases in China (SILC) epidemiological study

Systematic investigation of gastrointestinal diseases in China (SILC): validation of survey methodology

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