Symptomatic fracture incidence in elderly men and women: The Dubbo osteoporosis epidemiology study (DOES)

Abstract

This longitudinal population-based study documents the incidence of all symptomatic fractures from 1989 to 1992 in an elderly, predominantly Caucasian population of males and females (> or = 60 years as at 1 January 1989) living in the geographically isolated region of the city of Dubbo, NSW, Australia. Fractures were ascertained by reviewing reports from all radiology services in the region. There were 306 fractures in 271 patients during the study period representing 11,401 person-years of observation. In the 60-80 year age group only 10% of fractures involved the hip, while in the over-80 age group this proportion rose to 41%. Incidence of distal forearm, hip and total fractures increased exponentially in both sexes with increasing age. Rib fractures were relatively common, with incidence rates for rib fractures similar to those for humeral fractures. Overall fracture incidence was 2685 per 100,000 person-years (males 1940 per 100,000 and females 3250 per 100,000). Residual lifetime fracture risk in a person aged 60 years with average life expectancy was 29% for males and 56% for females. Symptomatic fracture rates with the improved methodology in this study were higher than previously reported in both elderly males and females, with a marked preponderance of non-hip fractures in the 60-80 year age group. These symptomatic fractures have previously been underestimated, if not largely ignored, in public health approaches including cost-benefit analyses of osteoporosis prevention and treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Genetic profiling and individualized prognosis of fracture

“…(20)(21)(22)(23) Briefly, in 1989, all men and women aged 60 years or above (as of 1989) living in Dubbo, a city of approximately 32,000 people 400 km northwest of Sydney (Australia), were invited to participate in an epidemiologic study. At that time, the population consisted of 1581 men and 2095 women aged 60 years or older, of whom 98.6% were white and 1.4% were indigenous aboriginal.…”

“…Fractures occurring during the study period were identified for residents of the Dubbo local government area through radiologists' reports from the two centers providing X-ray services, as described previously. (20,21) Fractures were included only if the report of fracture was definite and, on interview, had occurred with low trauma (eg, fall from standing height or less). Fractures clearly owing to major trauma (eg, motor vehicle accidents), those owing to underlying diseases (eg, cancer or bone-related diseases), or those of digit, skull, or cervical spine were excluded from the analysis.…”

Maternal diet during pregnancy is associated with bone mineral density in children: a longitudinal study

“…Fractures are a major public health problem in males as well as females (Jones et al, 1994). Bone density is one of the major predictors of osteoporotic fractures (Marshall et al, 1996) in the elderly and is the result of the amount of bone gained in early life (ie peak bone mass) and subsequent bone loss (Hansen et al, 1991).…”

Once-yearly zoledronic acid 5 mg therapy for osteoporosis: a focus on a patient

“…Эта категория пациентов не так давно привлекла внимание клиницистов, поскольку долго счита-лось, что ОП -сугубо женское заболевание. Каждый 4-й муж-чина старше 60 лет подвержен развитию переломов [32], 16% мужчин старше 50 лет и 35% старше 85 лет падают каждый год [33]. 30% переломов бедра и 20% переломов позвонков проис-ходит у мужчин [34].…”