Symptomatic late onset hypocalcemia in a full term female neonate with vitamin D deficiency due to maternal hypovitaminosis D: A rare case report

Chacham, Swathi; Ravikiran, Janampally; Reddy, Uppin Narayan; Rao, Jillalla Narsing; Reddy, Mahender; Imeduddin,

doi:10.5348/ijcri-201544-cr-10505

Cited by 1 publication

(1 citation statement)

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“…Causes of late onset of hypocalcaemia: hypomagnesemia, maternal vitamin D deficiency [12,13], malabsorption, renal insufficiency, hepatobiliary diseas, PTH resistence, primary and secondary hypoparathyroidism, metabolic syndromes (Kenny-caffey syndrome long-chain fatty acyl CoA dehydrogenase deficiency, Kearns-sayre syndrome), congenital abnormalities (DiGeorge syndrome), hypoalbuminemia, iatrogenic (lipid infusions, bicarbonate therapy, loop diuretics, glucocorticosteroids, phosphate therapy, alkalosis, phototherapy, antibiotics [14,15]. The cause of late-onset hypocalcemia is usually ingestion of cow's milk or baby formula soymilk with a high phosphate load; elevated serum phosphate leads to hypocalcemia [3,16].…”

Section: Neonatal Hypocalcemia With a Special Reference To Prematuritymentioning

confidence: 99%

Hypocalcemia of the newborn due to red blood cell transfusion: Case report

Otašević¹,

Petrović²,

Čolak³

et al. 2021

Hosp Pharm Int Multi J

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Introduction: Hypocalcemia in preterm infants could occurs as early or late. Causes of late onset of hypocalcaemia: maternal vitamin D deficiency, metabolic syndromes, congenital abnormalities, iatrogenic (transfusion, bicarbonate therapy, phototherapy, antibiotics). Case report: The authors describe the occurrence of late hypocalcemia following transfusion of erythrocytes to the second newborn from a twin pregnancy born prematurely in the 32/33 week of gestation. Mother is diabetic and has hypertension, edema, hypothyroidism, and preeclampsia during pregnancy. Due to the detected pyelectasis in newborn, prophylactic use of cephalexin was introduced. At the end of the first month of life, anemia appear indicating a transfusion. The infant received 50 ml an O+ leukodepleted RBC transfusion. Immediately after transfusion was completed, there is a short-term deterioration of the general condition. Cyanosis, stiffness, trismus, and bradycardia appear within a few seconds. DAT was negative, bilirubin in the reference range. After transfusion, laboratory, echosonographic examination, neurological examination, EEG and ECG showed normal results. It was concluded that the adverse reaction was probably caused by transfusion. Conclusion: In preterm infants, hypocalcaemia may occur during transfusion due to citrate overload. Children of diabetic mothers, on antibiotic and photo therapy are at higher risk of developing hypocalcemia. Future studies should evaluate incidence rate of adverse transfusion reactions in newborns.

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