Symptomatic Relief Associated With Eyelid Hygiene in Anterior Blepharitis and MGD

Guillon, Michel; Maïssa, Cécile; Wong, Stéphanie

doi:10.1097/icl.0b013e3182658699

Cited by 54 publications

(33 citation statements)

References 19 publications

(16 reference statements)

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“…[121-127] While lid hygiene is indicated primarily for anterior blepharitis, it does serve a role in the management of MGD (posterior blepharitis), possibly by exfoliation of lid debris and reducing lid margin bacterial load. [117,128,129]. Anti-microbials such as systemic tetracyclines (doxycyline, minocycline),[130-134] and topical macrolides (1% azithromycin), that also have anti-inflammatory properties are the most commonly prescribed treatments of MGD.…”

Section: Methods and Limitations In The Diagnosis And Treatment Of Mementioning

confidence: 99%

Image-guided evaluation and monitoring of treatment response in patients with dry eye disease

Qazi

Aggarwal

Hamrah

2014

Graefes Arch Clin Exp Ophthalmol

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Dry eye disease (DED) is one of the most common ocular disorders worldwide. The pathophysiological mechanisms involved in the development of DED are not well understood and thus treating DED has been a significant challenge for ophthalmologists. Most of the currently available diagnostic tests demonstrate low correlation to patient symptoms and have low reproducibility. Recently, sophisticated in vivo imaging modalities have become available for patient care, namely, in vivo confocal microscopy (IVCM) and optical coherence tomography (OCT). These emerging modalities are powerful and non-invasive, allowing real-time visualization of cellular and anatomical structures of the cornea and ocular surface. Here we discuss how, by providing both qualitative and quantitative assessment, these techniques can be used to demonstrate early subclinical disease, grade layer-by-layer severity, and allow monitoring of disease severity by cellular alterations. Imaging-guided stratification of patients may also be possible in conjunction with clinical examination methods. Visualization of subclinical changes and stratification of patients in vivo, allows objective image-guided evaluation of tailored treatment response based on cellular morphological alterations specific to each patient. This image-guided approach to DED may ultimately improve patient outcomes and allow studying the efficacy of novel therapies in clinical trials.

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Section: Methods and Limitations In The Diagnosis And Treatment Of Mementioning

confidence: 99%

Image-guided evaluation and monitoring of treatment response in patients with dry eye disease

Qazi

Aggarwal

Hamrah

2014

Graefes Arch Clin Exp Ophthalmol

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“…Symptomatology decreased rapidly and significantly: although all the subjects were symptomatic at enrollment on the Ocular Surface Disease Index questionnaire (score $ 13), the majority, 55% after 3 weeks and 54% after 3 months, were asymptomatic (score , 13). 23 …”

Section: Product Usage and Subjective Efficacymentioning

confidence: 97%

Eyelid Margin Modification Associated With Eyelid Hygiene in Anterior Blepharitis and Meibomian Gland Dysfunction

Guillon¹,

Maïssa²,

Wong³

2012

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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The results showed that eyelid hygiene with Blephaclean wipes by subjects with anterior blepharitis or MGD significantly improved the status of the eyelid margin tissues including the meibomian glands. The data confirmed the efficiency of the clinical methodology put forward of 3 weeks of intensive use (twice a day) of eyelid wipes followed by maintenance use (once a day) and that approach achieved a rapid improvement in tissue status and gland patency.

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“…Artificial tear supplements, which vary widely in their composition, serve to keep the ocular surface lubricated and help relieve patient discomfort 10 . Eyelid hygiene, of which many variations exist,12, 13, 14 removes bacteria from the eyelid margin and is a widely used treatment in the management of both blepharitis and meibomian gland dysfunction (MGD) 11 . Finally, omega-3 fatty acids play a role in dry eye management by reducing inflammation at the ocular surface 10 …”

Section: Introductionmentioning

confidence: 99%

The relief of dry eye signs and symptoms using a combination of lubricants, lid hygiene and ocular nutraceuticals

Ngo

Srinivasan

Houtman³

et al. 2017

Journal of Optometry

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PurposeTo determine the combined effect of TheraTears® Lubricant Eye Drops, TheraTears® SteriLid Eyelid Cleanser, and TheraTears® Nutrition on dry eye signs and symptoms.MethodsThis prospective study enrolled 28 dry eye participants. Participants were instructed to use the Lubricant Eye Drops at least 2–4× a day, SteriLid 1–2× a day, and Nutrition 3 gel caps once a day. Participants were followed up at baseline, 1 month and 3 months. Outcome variables were the Ocular Surface Disease Index (OSDI), Symptom Assessment iN Dry Eye (SANDE) questionnaire, non-invasive tear break-up time (NIBUT), osmolarity, number of meibomian glands blocked (#MG blocked), meibum quality, eyelid margin features, Schirmer's test, tear film lipid layer thickness (LLT), meniscus height, corneal and conjunctival staining.ResultsTwenty participants (mean age = 43, from 23 to 66, 17F, 3M) completed the study. Participants reported having used, on average, the Lubricant Eye Drop 2.4×/day, the SteriLid 1.1×/day, and the Nutrition 3 gel caps 1×/day. There was a significant change over time (p < 0.05) for OSDI (−21.2 points), SANDE (−32.4 points), NIBUT (+0.43 s), eyelid margin features (−1.1 grade), meibum quality (−1.0 grade), and #MG blocked (−4.0 glands).ConclusionBy using a combination of TheraTears® Lubricant Eye Drop, SteriLid, and Nutrition, patients experience significant relief in both dry eye symptoms and signs.

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Symptomatic Relief Associated With Eyelid Hygiene in Anterior Blepharitis and MGD

Cited by 54 publications

References 19 publications

Image-guided evaluation and monitoring of treatment response in patients with dry eye disease

Image-guided evaluation and monitoring of treatment response in patients with dry eye disease

Eyelid Margin Modification Associated With Eyelid Hygiene in Anterior Blepharitis and Meibomian Gland Dysfunction

The relief of dry eye signs and symptoms using a combination of lubricants, lid hygiene and ocular nutraceuticals

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