Symptoms at postmenopause

Zavala, Herlinda Aguilar; Pérez-Luque, Elva; Luna-Martínez, Francisco; Bassol-Mayagoitia, Susana; Canto-de-Cetina, Thelma; López-Conesa, Maillil; Malacara, Juan Manuel

doi:10.1097/gme.0b013e3182503bde

Cited by 14 publications

(8 citation statements)

References 26 publications

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“…[67891328] Furthermore, the current data suggest that there is a strong association between depression, anxiety and stress symptoms high rates in menopause and postmenopausal women: These findings are confirmative with some previous reported studies. [6789132122232425262728]…”

Section: Discussionmentioning

confidence: 99%

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Bener

Bakır

et al. 2016

Ann Med Health Sci Res

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Background:The association between depression, anxiety, and stress among Arab menopause and postmenopausal women have been explored in detailed.Aim:The objective of this study was to determine the correlation between depression, anxiety, and stress in menopausal and postmenopausal women and shedding more light on a complex relationship.Subjects and Methods:A cross-sectional descriptive study was used to generate menopause symptoms experienced by Arabian women at the primary health care centers in Qatar. A representative sample of 1468 women aged 45–65 years were approached during July 2012 and May 2014 and 1101 women agreed to participate (75.0%) and responded to the study. Depression, anxiety, and stress were measured using the Depression Anxiety Stress Scales 21. Data on body mass index (BMI), clinical and other parameters were used. Univariate, multivariate, and matrix correlation analysis were performed for statistical analysis.Results:A total of 1101 women agreed to participate after informed consent was obtained. The mean age and standard deviation (SD) of the menopausal age were 49.55 (3.12), the mean and SD of postmenopausal age was 58.08 (3.26) (P < 0.001). There were statistically significant differences between menopausal stages with regards to age, ethnicity, educational status, occupation status, and place of living. Furthermore, there were statistically significant differences between menopausal stages with regards to BMI, systolic and diastolic blood pressure (BP), Vitamin D deficiency, and diseases. Depression and anxiety were more common among postmenopause women. Furthermore, there were no differences between the groups regarding the frequency of certain levels of stress among menopause and postmenopause. The multivariate regression analyses revealed that age in years, diastolic BP, consanguinity, regular exercise were a predictor for depression. Meanwhile, diastolic BP, occupation, and physical activity considered the main risk factors for anxiety. Furthermore, age in years, occupation, and sheesha smoking habits were considered as the main risk factors associated with stress.Conclusion:A large number of factors were associated with experiencing menopausal and psycho-social problems and which had negative effects on the quality of life among Arabian women. Depression, anxiety, and stress should be considered as important risk factors for osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Bener

Bakır

et al. 2016

Ann Med Health Sci Res

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“…Women answered a symptoms’ questionnaire validated and used in previous works by our group [ 2 , 27 ] to assess hot flashes, depressive mood, and anxiety.…”

Section: Methodsmentioning

confidence: 99%

“…Menopause is the permanent cessation of menses as a result of the irreversible loss of ovarian functions with the decline of estrogen levels [ 1 ]. Women at this stage may suffer vasomotor (hot flashes and sweats), and emotional (anxiety and depressive mood) symptoms, resulting from estrogen diminution and other associated factors [ 2 ], among which low-grade chronic inflammation has been recently identified [ 3 ]. These conditions may have a severe effect in women’s quality of life, with a progressive risk for cardiovascular diseases (CVD) [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Adhesion Molecules, Pro-Inflammatory Cytokines and Cell-Derived Microparticles Contribute to Intima-Media Thickness and Symptoms in Postmenopausal Women

Figueroa-Vega

Moreno-Frías

2015

PLoS ONE

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Menopause, the cessation of menses, occurs with estrogens decline, low-grade inflammation, and impaired endothelial function, contributing to atherosclerotic risk. Intima-media thickness (IMT) is an early subclinical biomarker of atherosclerosis. Inflammation may have a role on symptoms: hot flashes, anxiety, and depressive mood, which also are related to endothelial dysfunction, increased IMT and cardiovascular risk. In this study we compared several inflammatory markers in early vs. late postmenopausal women and studied the association of IMT and symptoms with these markers in the full sample. In a cross-sectional design including 60 women (53.1±4.4 years old) at early and late postmenopause, we evaluated the expression of CD62L, ICAM-1, PSGL-1, CD11b, CD11c, and IL-8R on PBMC by flow cytometry. Serum soluble ICAM-1, sVCAM-1, sCD62E, sCD62P, CXCL8, IL-1β, IL-6, and TNF-α levels were quantified by ELISA. Plasma levels of microparticles (MPs) were determined by FACS. Finally, carotid intima-media thickness (IMT) was measured by ultrasound. We observed that ICAM-1 expression by lymphocytes and serum sVCAM-1 levels were augmented at late postmenopause. Late postmenopause women with severe hot flashes had increased expression of CD62L and IL-8R on neutrophils. By multivariate analysis, the carotid IMT was strongly associated with membrane-bound TNF-α, CD11b expression, Annexin V+ CD3+ MPs, LPS-induced NO production, HDL-cholesterol and age. Depressive mood was associated negatively with PSGL-1 and positively with LPS-induced NO. Finally, Log(AMH) levels were associated with carotid IMT, IL-8R expression and time since menopause. IMT and depressive mood were the main clinical features related to vascular inflammation. Aging, hormonal changes and obesity were also related to endothelial dysfunction. These findings provide further evidence for a link between estrogen deficiency and low-grade inflammation in endothelial impairment in mature women.

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“…A recent article on the QoL of postmenopausal women from three cities in Mexico did not show a direct relation between menopause symptoms and genetic factors. 39 Moreover, it seems that the lower frequency of hot flushes found among the Japanese women of the Hilo Women's Health Study is attributable to reporting bias rather than to biological factors. 40 The reasons for the diversity of menopausal symptoms and their impact on QoL are still largely unknown.…”

Section: Andmentioning

confidence: 99%

Comparative study of the quality of life associated with menopause in Tunisia and France

Ferrand

Hajri

Benzineb³

et al. 2013

Menopause

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Symptoms at postmenopause

Abstract: Symptoms at postmenopause were associated mainly with dominance, submission, and effort-reward imbalance. The pp genotype of ER-α showed lower scores of dominance.

Cited by 14 publications

References 26 publications

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Depression, anxiety, and stress symptoms in menopausal arab women: Shedding more light on a complex relationship

Alterations in Adhesion Molecules, Pro-Inflammatory Cytokines and Cell-Derived Microparticles Contribute to Intima-Media Thickness and Symptoms in Postmenopausal Women

Comparative study of the quality of life associated with menopause in Tunisia and France

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