Symptoms compatible with Rome IV functional bowel disorder in patients with ankylosing spondylitis

Abstract

Objectives To determine the frequency of symptoms meeting Rome IV functional bowel disorder (FBD) in patients with ankylosing spondylitis (AS), investigate factors associated with FBD symptoms, and assess whether having FBD symptoms might influence AS disease activity. Methods In this cross-sectional study, we enrolled 153 AS patients without known colonic ulcer and 56 sex- and age-matched controls to evaluate FBD (or its subtypes) symptoms. Disease characteristics were also evaluated in AS group. Results Sixty (39.2%) of 153 AS patients had FBD symptoms, which was more prevalent than controls (23.2%). Besides, symptoms compatible with irritable bowel syndrome (IBS) and chronic diarrhea were detected in 18 and 43 AS patients respectively. For AS group, multivariable logistic regression analyses showed that symptoms of FBD, IBS, and chronic diarrhea were negatively associated with using non-steroidal anti-inflammatory drug (NSAID), and positively associated with comorbid fibromyalgia, respectively. In exploration about effects of FBD (or its subtypes) symptoms on AS disease activity by multivariable linear regression analyses, FBD symptoms and chronic diarrhea had universal positive associations with assessments of AS disease characteristics respectively. Conclusion Patients with AS had frequent symptoms compatible with FBD, IBS, and chronic diarrhea, proportions of which were lower in those with NSAID-use. The improvement of FBD symptoms and chronic diarrhea might be conducive to disease status of AS patients.

Bioinformatics Analysis of Immune Cell Infiltration and Diagnostic Biomarkers between Ankylosing Spondylitis and Inflammatory Bowel Disease

“…Therefore, exploring the molecular mechanisms between AS and IBD, early identification, and intervention undoubtedly have important clinical significance. According to earlier research, AS and IBD own have their unique genetic inheritance [ 27 , 28 ], and the activity of the two diseases affects one another [ 29 , 30 ]. As a result, scientists focus primarily on genetics to investigate the comorbidity mechanism of the two illnesses.…”

Dietary Fiber Intake Influences Changes in Ankylosing Spondylitis Disease Status

“…The smart phone Spondyloarthritis Management System (SpAMS) application was used to document the assessment of AS [ 18 ], including the Ankylosing Spondylitis Disease Activity Score based on C-reactive protein (ASDAS-CRP), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Assessment of the Spondyloarthritis International Society Health Index (ASAS HI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Metrology Index (BASMI) [ 19 , 20 , 21 , 22 , 23 ]. Gut problems, including abdominal pain, constipation, diarrhea, and bloating had been investigated and reported previously [ 6 ].…”

“…Recent studies have suggested that improvement in FBD symptoms, particularly chronic diarrhea, may positively impact the disease state of individuals diagnosed with AS. This raises the possibility that addressing FBD symptoms may play a role in managing the overall condition of individuals with AS [ 6 ].…”