Synapse–glia interactions are governed by synaptic and intrinsic glial properties

Rousse, Isabelle; St.-Amour, A.; Darabid, Houssam; Robitaille, Richard

doi:10.1016/j.neuroscience.2010.02.036

Cited by 23 publications

(24 citation statements)

References 30 publications

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“…At adult NMJs, detection of synaptic transmission by PSCs is mediated by muscarinic receptors (M1, M3, or M5) (Wright et al 2009) and by purinergic receptors, in particular adenosine A1 receptors (Rochon et al 2001). Although the characterization of the muscarinic receptor system follows a clear nomenclature, the properties of the purinergic receptor systems still elude a clear classification (Robitaille et al 1997;Rochon et al 2001;Rousse et al 2010).…”

Section: Pscs Detect Synaptic Transmissionmentioning

confidence: 99%

“…For instance, PSCs of weaker (e.g., soleus muscle) and stronger (levator auris longus [LAL] muscle) NMJs respond differently to nerve-evoked release of neurotransmitters where the weaker synapses systematically evoked smaller Ca 2þ elevation in PSCs. These differences are largely the result of the different intrinsic properties of the PSCs at the different synapses (Rousse et al 2010 …”

Section: Pscs Detect Synaptic Transmissionmentioning

confidence: 99%

“…4F) (Darabid et al 2013). Importantly, PSC Ca 2þ responses were unaltered in the presence of the K þ channel blocker (tetraethylamonium [TEA]), which increased transmitter release without affecting directly PSCs excitability (Rousse et al 2010;Darabid et al 2013). This indicates that differences in Ca 2þ kinetics elicited by the two nerve terminals were also determined by intrinsic properties of PSCs.…”

Section: Pscs Decode Synaptic Properties and Activitymentioning

confidence: 99%

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Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells

Robitaille

2015

Cold Spring Harb Perspect Biol

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The neuromuscular junction (NMJ) is engineered to be a highly reliable synapse to carry the control of the motor commands of the nervous system over the muscles. Its development, organization, and synaptic properties are highly structured and regulated to support such reliability and efficacy. Yet, the NMJ is also highly plastic, able to react to injury and adapt to changes. This balance between structural stability and synaptic efficacy on one hand and structural plasticity and repair on another hand is made possible by the intricate regulation of perisynaptic Schwann cells, glial cells at this synapse. They regulate both the efficacy and structural plasticity of the NMJ in a dynamic, bidirectional manner owing to their ability to decode synaptic transmission and by their interactions via trophic-related factors.

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Section: Pscs Detect Synaptic Transmissionmentioning

confidence: 99%

Section: Pscs Detect Synaptic Transmissionmentioning

confidence: 99%

Section: Pscs Decode Synaptic Properties and Activitymentioning

confidence: 99%

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Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells

Robitaille

2015

Cold Spring Harb Perspect Biol

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“…In addition, Schwann cell intrinsic factor appears to affect Schwann cell responses [77]. Schwann cells in fast-twitch muscles always showed stronger Ca 2+ response compared with those in slow-twitch muscle regardless of stimulation frequency or level of transmitter release [77].…”

Section: Role Of Schwann Cells In Modulating Neuromuscular Synaptic Tmentioning

confidence: 99%

“…Schwann cells in fast-twitch muscles always showed stronger Ca 2+ response compared with those in slow-twitch muscle regardless of stimulation frequency or level of transmitter release [77]. Thus the characteristic of synaptic activity is not the only determinant but the muscle type also affects Schwann cell modulation.…”

Section: Role Of Schwann Cells In Modulating Neuromuscular Synaptic Tmentioning

confidence: 99%

Neuron–glia interactions: the roles of Schwann cells in neuromuscular synapse formation and function

Sugiura

Lin

2011

Bioscience Reports

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Synopsis The NMJ (neuromuscular junction) serves as the ultimate output of the motor neurons. The NMJ is composed of a presynaptic nerve terminal, a postsynaptic muscle and perisynaptic glial cells. Emerging evidence has also demonstrated an existence of perisynaptic fibroblast-like cells at the NMJ. In this review, we discuss the importance of Schwann cells, the glial component of the NMJ, in the formation and function of the NMJ. During development, Schwann cells are closely associated with presynaptic nerve terminals and are required for the maintenance of the developing NMJ. After the establishment of the NMJ, Schwann cells actively modulate synaptic activity. Schwann cells also play critical roles in regeneration of the NMJ after nerve injury. Thus, Schwann cells are indispensable for formation and function of the NMJ. Further examination of the interplay among Schwann cells, the nerve and the muscle will provide insights into a better understanding of mechanisms underlying neuromuscular synapse formation and function.

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The Schwann Cell as an Active Synaptic Partner

et al. 2018

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The schwann cells of the peripheral nervous system are indispensable for the formation, maintenance, and modulation of synapses over the life cycle. They not only recognize neuron-glia signaling molecules, but also secrete gliotransmitters. Through these processes, they regulate neuronal excitability and thus the release of neurotransmitters from the nerve terminal at the neuromuscular junction. Gliotransmitters strongly affect nerve communication, and their secretion is mainly triggered by synchronized Ca signaling, implicating Ca waves in synapse function. Reciprocally, neurotransmitters released during synaptic activity can evoke increases in intracellular Ca levels. A reconsideration of the interplay between the two main types of cells in the nervous system is due, as the concept of nervous system activity comprising only neuron-neuron and neuron-muscle action has become untenable. A more precise understanding of the roles of schwann cells in nerve-muscle signaling is required.

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Synapse–glia interactions are governed by synaptic and intrinsic glial properties

Cited by 23 publications

References 30 publications

Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells

Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells

Neuron–glia interactions: the roles of Schwann cells in neuromuscular synapse formation and function

The Schwann Cell as an Active Synaptic Partner

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