Synaptic connectivity amongst components of the locomotor central pattern generator

Abstract

In the past two decades we have learned an enormous amount of information regarding the identity of functional components of the neural circuitry responsible for generating locomotor activity in mammals. Molecular techniques, combined with classic electrophysiological and anatomical approaches, have resulted in the identification of a handful of classes of genetically defined interneuronal populations, and a delineation of the specific function of many of these during stepping. What lags behind at this point is a clear picture of the synaptic connectivity of each population, this information is key if we are to understand how the interneuronal components that are responsible for locomotor activity work together to form a functional circuit. In this mini review I will summarize what is, and what is not, known regarding the synaptic connectivity of each genetically defined interneuronal population that is involved in locomotion.

Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole

“…GBM tumor growth in the striatum may lead to impaired hindlimb displacement and motor impairment in each step cycle [ 37 ]. Further studies are needed to establish the relationship between lesion location resulting in the effects of tumors, or the pathways producing changes in the spinal cord central pattern generators [ 41 ]. Following the motor deficit found in our experiments, treatment and rehabilitation will depend on previous treatments, tumor area swelling, and invasivity.…”